Unlocking the Interactions Between the Whole-Body Microbiome and HPV Infection: A Literature Review

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 293 - 293

Published: March 18, 2025

The human microbiome plays a vital role in maintaining homeostasis, acting as key regulator of host immunity and defense mechanisms. However, dysbiotic microbial communities may cause disruption the symbiotic relationship between local microbiota, leading to pathogenesis various diseases, including viral infections cancers. One most common infectious agents causing cancer is papilloma virus (HPV), which accounts for more than 90% cervical In cases, immune system activated clears HPV, whereas some infection persists can lead precancerous lesions. Over last two decades, advent next-generation sequencing (NGS) technology bioinformatics has allowed thorough in-depth analysis composition anatomical niches, allowing researchers unveil interactions underlying mechanisms through microbiota could affect HPV establishment, persistence, progression. Accordingly, present narrative review aims shed light on our understanding context its progression, mainly cancer. Furthermore, we explore by balance exert potential pathogenic or protective effects, either persistence disease outcomes clearance. Special interest given how modulate infection. Lastly, summarize latest findings therapeutic efficacy probiotics prebiotics preventing and/or treating vaginal transplantation while highlighting significance personalized medicine approaches emerging from NGS-based profiling artificial intelligence (AI) optimal management HPV-related diseases.

Language: Английский

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Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review

Infectious Diseases and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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The Gut Microbiome and Its Multifaceted Role in Cancer Metabolism, Initiation, and Progression: Insights and Therapeutic Implications

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: April 1, 2025

This review summarizes the intricate relationship between microbiome and cancer initiation development. Microbiome alterations impact metabolic pathways, immune responses, gene expression, which can accelerate or mitigate progression. We examine how dysbiosis affects tumor growth, metastasis, treatment resistance. Additionally, we discuss potential of microbiome-targeted therapies, such as probiotics fecal microbiota transplants, to modulate metabolism. These interventions offer possibility reversing controlling progression, enhancing efficacy traditional treatments like chemotherapy immunotherapy. Despite promising developments, challenges remain in identifying key microbial species pathways validating therapies through large-scale clinical trials. Nonetheless, intersection research development presents an exciting frontier for innovative therapies. offers a fresh perspective on by integrating insights, highlighting interdisciplinary enhance our understanding progression strategies.

Language: Английский

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The role of probiotics, prebiotics, and synbiotics in the treatment of inflammatory bowel diseases: an overview of recent clinical trials

Frontiers in Systems Biology, Journal Year: 2025, Volume and Issue: 5

Published: April 16, 2025

Background The increasing incidence of inflammatory bowel diseases (IBD) over the last two decades has prompted need to create new types therapeutic interventions. gut microbiome emerged as a key component in prognosis and pathophysiology IBDs. alteration or dysbiosis been shown exacerbate bacterial composition can be modulated through usage probiotics, prebiotics, synbiotics. These interventions induce growth beneficial bacteria. Additionally, these could used maintain homeostasis, reduce inflammation seen morbidities, strengthen epithelial barrier. Methods literature review was conducted October 2024 using PubMed, Scopus, Google Scholar screening for recent clinical trials addition reviews relevant topic. Aims This aims summarize synbiotics IBD patients highlighting their potential benefits alleviating symptoms enhancing quality life. Conclusion Certain probiotic formulations such single strain ones consisting Lactobacillus, mixed-strain combinations Lactobacillus Bifidobacterium , prebiotic compounds fructooligosaccharides, synbiotic both have proven effective improving clinical, immunological, symptomatic aspects disease course. While promising, findings remain inconclusive due inconsistent study designs, small sample sizes, varying patient responses. emphasizes larger, well-controlled determine efficacy.

Language: Английский

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Antibiotic Cocktail Exacerbates Esomeprazole-Induced Intestinal Dysmotility While Ameliorating Gastric Dyspepsia in Mice

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 442 - 442

Published: April 27, 2025

Background/Objectives: Esomeprazole, a proton pump inhibitor (PPI), is commonly prescribed for gastric-acid-related disorders but has been associated with impaired gastrointestinal (GI) motility long-term use. However, the effect of concurrent antibiotic administration on this dysfunction remains unclear. Therefore, study aimed to investigate effects antibiotics esomeprazole-induced GI and explore underlying mechanisms in mouse model. Methods: Male C57BL/6 mice were orally administered esomeprazole (160 mg/kg) five times per week 4 weeks. Three days before initiating treatment, broad-spectrum cocktail (ABX) consisting ampicillin (1 g/kg), neomycin metronidazole vancomycin (0.5 g/kg) was provided drinking water maintained throughout experimental period. Mosapride (3 mg/kg), prokinetic agent, used as positive control. Results: Neither alone nor combination ABX affected body weight or food intake. Compared normal controls, treatment significantly delayed both intestinal transit gastric emptying. co-administration further pronounced time improved motility. The potential may involve interactions among H+/K+-ATPase, CYP3A11, hormones (secretin motilin), gut microbiome. Conclusions: Long-term use can impair motility, co-treatment exacerbates delay while paradoxically enhancing These findings highlight critical role microbiota suggest that should be approached caution, particularly when combined PPI therapy.

Language: Английский

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Bile Acids as Emerging Players at the Intersection of Steatotic Liver Disease and Cardiovascular Diseases

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 841 - 841

Published: July 12, 2024

Affecting approximately 25% of the global population, steatotic liver disease (SLD) poses a significant health concern. SLD ranges from simple steatosis to metabolic dysfunction-associated steatohepatitis and fibrosis with risk severe complications such as cirrhosis hepatocellular carcinoma. is associated obesity, atherogenic dyslipidaemia, insulin resistance, increasing cardiovascular risks. As such, identifying vital for (CVD) prevention treatment. Bile acids (BAs) have critical roles in lipid digestion are signalling molecules regulating glucose metabolism influencing gut microbiota balance. BAs been identified mediators health, vascular tone, cholesterol homeostasis, inflammatory responses. The cardio-protective or harmful effects depend on their concentration composition circulation. certain occur through activation group receptors, which reduce atherosclerosis modulate cardiac functions. Thus, manipulating BA receptors could offer new avenues treating not only diseases but also CVDs linked dysfunctions. In conclusion, this review discusses intricate interplay between BAs, pathways, hepatic extrahepatic diseases. We highlight necessity further research improve our understanding how modifying characteristics affects ameliorates disease.

Language: Английский

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Postoperative delayed gastric emptying: may gut microbiota play a role?

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 13, 2024

Postoperative delayed gastric emptying is a prevalent complication following surgical procedures, imposing heavy physical and financial burdens on patients. However, current treatment options remain suboptimal. In recent years, an increasing number of studies have highlighted that the gut microbiota its metabolites are closely associated with postoperative complications. Various factors can disrupt microbiome after surgery. This review discusses potential mechanisms by which their may contribute to pathogenesis emptying. knowledge base limited in terms fully understanding exact involved. It therefore evident further research required elucidate role emptying, aim uncovering new possibilities for preventive measures therapeutic treatments.

Language: Английский

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The correlation between fecal microbiota profiles and intracellular junction genes expression in young Iranian patients with celiac disease

Tissue Barriers, Journal Year: 2024, Volume and Issue: unknown

Published: May 2, 2024

Celiac disease (CD) is characterized by the disruption of intestinal barrier integrity and alterations in microbiota composition. This study aimed to evaluate changes fecal profile mRNA expressions intracellular junction-related genes pediatric patients with CD compared healthy controls (HCs). Thirty treated patients, 10 active CD, 40 HCs were recruited. Peripheral blood (PB) samples collected. Microbiota analysis was performed using quantitative real-time PCR (qPCR) test. The ZO-1, occludin, β-catenin, E-cadherin, COX-2 also evaluated. In PB expression levels ZO-1 (

Language: Английский

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THE LEAKY GUT AND HUMAN DISEASES: “CAN’T FILL THE CUP IF YOU DON'T PLUG THE HOLES FIRST”

Digestive Diseases, Journal Year: 2024, Volume and Issue: 42(6), P. 548 - 566

Published: July 24, 2024

The gut barrier is a sophisticated and dynamic system that forms the frontline defense between external environment body's internal milieu includes various structural functional components engaged not only in digestion nutrient absorption but also immune regulation overall health maintenance.

Language: Английский

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The Gut Microbiome in Sepsis: From Dysbiosis to Personalized Therapy

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6082 - 6082

Published: Oct. 12, 2024

Sepsis is a complex clinical syndrome characterized by an uncontrolled inflammatory response to infection that may result in septic shock and death. Recent research has revealed crucial link between sepsis alterations the gut microbiota, showing microbiome could serve essential function its pathogenesis prognosis. In sepsis, microbiota undergoes significant dysbiosis, transitioning from beneficial commensal flora predominance of pathobionts. This transformation can lead dysfunction intestinal barrier, compromising host's immune response, which contributes severity disease. The intricate system protozoa, fungi, bacteria, viruses are for maintaining immunity metabolic balance. there reduction microbial heterogeneity pathogenic such as proteobacteria, exacerbate inflammation negatively influence outcomes. Microbial compounds, short-chain fatty acids (SCFAs), perform task modulating barrier function. However, role other components, remains unclear. Innovative therapeutic strategies aim modulate improve management sepsis. These include selective digestive decontamination (SDD), probiotics, prebiotics, synbiotics, postbiotics, fecal transplantation (FMT), all have shown potential, although variable, results. future benefit greatly personalized treatment based on microbiota. Rapid easy-to-implement tests assess profiles metabolites associated with revolutionize disease's diagnosis management. approaches not only patient prognosis but also reduce dependence antibiotic therapies promote more targeted sustainable strategies. Nevertheless, still limited clarity regarding ideal composition should be further near future. Similarly, benefits validated through additional studies.

Language: Английский

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