Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation DOI Creative Commons
Alec Peters,

Fatima Banine,

Kanon Yasuhara

et al.

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 107916 - 107916

Published: Oct. 1, 2024

Language: Английский

Impacts of Hyaluronan on Extracellular Vesicle Production and Signaling DOI Creative Commons
Melanie A. Simpson

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 139 - 139

Published: Jan. 18, 2025

Hyaluronan (HA) is a critical component of cell and tissue matrices an important signaling molecule. The enzymes that synthesize process HA, as well the HA receptors through which properties are transmitted, have been identified in extracellular vesicles implicated context-specific processes associated with health disease. goal this review to present comprehensive summary research on its related vesicle biogenesis cellular responses bearing these matrix modulators. When vesicles, assumed be outside sometimes found CD44 or HAS enzyme itself. Hyaluronidases may inside surface via transmembrane domain GPI linkage. implication presenting signals there greater range systemic distribution more complex delivery media than previously thought for secreted hyaluronidase alone. Understanding context offers new diagnostic therapeutic insight.

Language: Английский

Citations

0
Perspective Chapter: Next-Generation Sequencing and Variant Cataloging for Screening and Diagnosis of Sphingolipidoses and Mucopolysaccharidoses DOI Creative Commons
Irina Vlasova-St. Louis,

Uri Barak,

Svetlana F. Khaiboullina

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

This chapter provides a comprehensive examination of how next-generation sequencing (NGS) technologies are transforming prenatal and neonatal care, particularly in the diagnosis lysosomal diseases (LDs). These rare, inherited conditions caused by defects metabolism. If not detected treated early, they can lead to significant disabilities reduced life expectancy. The specifically focuses on use NGS diagnose screen sphingolipidoses (SLDs) mucopolysaccharidoses (MPSs). It covers molecular pathogenesis, classification, main symptomatology diseases. reviews progress made identifying genes associated with SLDs MPSs cataloging clinically relevant genetic variants. Additionally, it highlights growing adoption for screening institutions such as academic research centers, private healthcare providers, government health agencies. also discusses challenges implementation, regulation, outlines future directions its application medicine.

Language: Английский

Citations

0
Hyaluronidase 2 deficiency due to novel compound heterozygous variants in HYAL2: a case report of siblings with HYAL2 deficiency showing different clinical severity and literature review DOI

Ryuta Orimoto,

Eriko Adachi,

Maki Gau

et al.

Journal of Human Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Language: Английский

Citations

0
Comparative fluorophotometric evaluation of the ocular surface retention time of cross-linked and linear hyaluronic acid ocular eye drops on healthy dogs DOI
Andressa Lopes Grego,

Andy D Fankhauser,

Emily K Behan

et al.

Veterinary Research Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Language: Английский

Citations

3
Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation DOI Creative Commons
Alec Peters,

Fatima Banine,

Kanon Yasuhara

et al.

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 107916 - 107916

Published: Oct. 1, 2024

Language: Английский

Citations

0