Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2908 - 2908
Published: Dec. 20, 2024
The
placenta
is
a
vital
organ
that
supports
fetal
development
by
mediating
nutrient
and
gas
exchange,
regulating
immune
tolerance,
maintaining
hormonal
balance.
Its
formation
function
are
tightly
linked
to
the
processes
of
embryo
implantation
establishment
robust
placental-uterine
interface.
Recent
advances
in
molecular
biology
histopathology
have
shed
light
on
key
regulatory
factors
governing
these
processes,
including
trophoblast
invasion,
spiral
artery
remodeling,
chorionic
villi.
This
review
integrates
morphological
perspectives
placental
development,
emphasizing
roles
cytokines,
growth
factors,
signaling
pathways,
such
as
VEGF
Notch
signaling,
orchestrating
formation.
intricate
interplay
between
regulation
adaptations
highlights
placenta’s
critical
role
dynamic
interface
pregnancy.
synthesizes
current
findings
offer
clinicians
researchers
comprehensive
understanding
implantation,
its
importance
maternal-fetal
medicine.
By
integrating
insights,
lays
groundwork
for
advancing
diagnostic
therapeutic
approaches
can
enhance
pregnancy
outcomes
address
related
complications
effectively.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(1), P. 106 - 106
Published: Jan. 11, 2025
The
window
of
implantation
(WOI)
is
a
critical
phase
the
menstrual
cycle
during
which
endometrial
lining
becomes
receptive
and
facilitates
embryo
implantation.
Drawing
on
findings
from
various
branches
“omics”,
including
genomics,
epigenomics,
transcriptomics,
proteomics,
lipidomics,
metabolomics,
microbiomics,
this
narrative
review
aims
to
(1)
discuss
mechanistic
insights
receptivity
its
implication
in
infertility;
(2)
highlight
advances
investigations
for
receptivity;
(3)
novel
diagnostic
therapeutic
strategies
that
may
improve
reproductive
outcomes.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 289 - 289
Published: Jan. 24, 2025
Objective:
This
study
investigated
the
effects
of
a
supraphysiological
dose
testosterone
on
uterine
morphology
and
regulation
leukaemia
inhibitory
factor
(LIF)
signalling
pathway
during
endometrial
receptivity.
Methods:
In
this
study,
30
adult
female
Sprague–Dawley
rats
were
divided
into
treatment
control
groups.
The
groups
received
subcutaneous
injections
1
mg/kg/day
from
gestational
day
to
3,
either
alone
or
in
combination
with
inhibitors
(anastrozole,
finasteride,
both).
A
group
six
untreated
was
maintained
for
comparison.
Rats
euthanised
evening
4
examine
morphological
changes,
gene
expression
distribution
proteins
associated
LIF
(LIF,
LIFR,
JAK1
STAT3)
MUC1
by
quantitative
polymerase
chain
reaction
(qPCR)
immunohistochemistry
(IHC),
respectively.
Results:
results
showed
that
thickness
endometrium
myometrium,
as
well
number
glands,
markedly
decreased
all
testosterone-treated
rats.
addition,
mRNA
levels
LIF,
STAT3
significantly
downregulated
response
treatment,
while
upregulated.
IHC
consistent
data
confirmed
changes
protein
Conclusions:
may
impair
receptivity
through
dysregulation
pathway,
potentially
affecting
fertility.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 10, 2025
Introduction
Maternal
lifestyle
impacts
reproductive
performance.
Previously,
we
demonstrated
that
maternal
environmental
enrichment
promotes
pregnancy
success
in
BALB/c
mice.
As
progesterone
regulates
gestation,
decided
to
study
the
effect
of
on
ovarian
physiology
during
early
gestation.
Methods
For
this,
six-week-old
female
mice
were
housed
enriched
or
control
cages
for
six
weeks
and
then
mated
with
fertile
males.
Females
a
mucus
plug
returned
their
respective
cages.
Pregnant
euthanized
day
7
pregnancy,
ovaries
levels
investigated.
Results
Hematoxylin
eosin
slices
showed
no
differences
area
(μm
2
)
between
females.
Also,
number
primordial,
primary,
preantral,
antral,
atretic
follicles
was
similar
both
treatments.
However,
corpora
lutea
increased
from
group.
Moreover,
females
presented
higher
serum
3β-HSD
expression.
Discussion
Therefore,
physiology,
this
could
promote
benefits
previously
reported.
International Journal of Women s Health,
Journal Year:
2025,
Volume and Issue:
Volume 17, P. 615 - 625
Published: March 1, 2025
Depression
is
one
of
the
leading
sources
disease
burden
globally
and
plays
a
significant
role
in
occurrence
development
many
cancers,
representing
an
important
health
risk.
However,
relationship
between
depression
risk
gynecologic
cancers
has
not
been
fully
assessed.
This
study
aims
to
explore
association
cancers.
We
selected
11,574
participants
from
NHANES
2009-2018
cycles,
among
which
274
had
cancer
(GC),
137
cervical
(CC),
48
ovarian
(OC),
89
endometrial
(EC).
Box
plots
were
used
assess
differences
PHQ-9
scores
non-cancer
groups.
Logistic
regression
models
restricted
cubic
spline
(RCS)
employed
evaluate
Subgroup
analyses
interaction
tests
examined
consistency
across
different
characteristics.
There
was
difference
group
group.
In
multivariable
logistic
analysis,
positively
correlated
with
GC,
OC,
EC,
while
no
found
CC
Additionally,
RCS
model
also
indicated
nonlinear
subgroup
suggested
that
OC
consistent
groups,
whereas
GC
EC
showed
heterogeneity
relation
race
marital
status.
Specifically,
higher
levels
are
associated
increased
Future
attention
should
be
given
impact
on
incidence
particularly
EC.
BMC Pregnancy and Childbirth,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 10, 2025
The
echo
pattern
constitutes
an
ultrasonic
index
that
reflects
the
characteristics
of
endometrium
across
various
phases
menstrual
cycle.
However,
consensus
endometrial
and
pregnancy
outcomes
is
lacking
in
clinical
application.
retrospective
cohort
study
analyzed
data
from
electronic
records
women
who
underwent
frozen
embryo
transfer
(FET)
with
hormone
replacement
treatment
(not
only
one
cycle
per
patient)
between
July
2020
to
August
2021
at
Reproduction
Medicine
Center
Jbnminling
Hospital
Medical
College
Nanjing
University.
A
total
138
cleavage
stage
cycles
561
blastocyst
were
this
study.
Transvaginal
ultrasound
scans
performed
on
day.
was
classified
into
four
types:
A,
B,
B-C
C.
Pattern
defined
as
trilinear
type,
C
non-trilinear
type.
All
conducted
by
experienced
clinicians,
images
reviewed
same
two
physicians.
measured
included
implantation
rate,
first
trimester
abortion
live
birth
rate.
For
conforms
a
normal
distribution,
independent
sample
t-tests
are
used
for
comparison
groups,
one-way
analysis
variance
(ANOVA)
among
multiple
groups.
does
not
conform
rank
sum
tests
(Kruskal-Wallis
test)
inter-group
comparisons.
Count
using
chi-square
tests.
Logistic
regression
models
applied
outcome.
rate
(p
=
0.066),
0.140),
early
0.515)
0.578)
similar
4
type
groups
cleavage-stage
FET
cycles.
In
cycles,
0.201)
0.555)
did
differ
patterns.
Patients
day
decreased
(19.05%)
compared
0.006.
p
0.008,
0.031
vs.
B-C,
C).
up
40.00%,
although
there
no
statistical
difference
0.118).
group,
miscarriage
(0.248
[95%
CI,
0.067-0.914];
0.036)
lower
(0.269
0.089-0.810];
0.020)
higher
than
group.
Our
suggests
associated
