Injectable Carbon Dots-Based Hydrogel for Combined Photothermal Therapy and Photodynamic Therapy of Cancer DOI
Juan Yue, Peng Miao, Li Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(44), P. 49582 - 49591

Published: Oct. 26, 2022

Hydrogel has been widely used in modern biotherapeutics due to its excellent biocompatibility, degradability, and high drug loading capacity. Among them, the construction of a phototherapy system including photosensitizer hydrogel aroused great interest tumor therapy. Unfortunately, complex modifications are necessary integrate different photosensitizers into hydrogel. In this work, an injectable was proposed by Schiff base reaction between HA-CHO carbon dots (CDs), which can realize PTT simultaneously. Notably, CDs with rich −NH2 be not only as but also efficient cross-linking agent for form network. The CD@Hydrogel outstanding biosafety showed antitumor effect after 660 nm laser irradiation vitro vivo experiments. summary, PDT synergistic treatment under one light source act react hydrogel, is simple efficient, providing new strategy cancer phototherapy.

Language: Английский

Sex differences in cancer mechanisms DOI Creative Commons
Joshua B. Rubin, J. S. Lagas, Lauren Broestl

et al.

Biology of Sex Differences, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 15, 2020

We now know that cancer is many different diseases, with great variation even within a single histological subtype. With the current emphasis on developing personalized approaches to treatment, it astonishing we have not yet systematically incorporated biology of sex differences into our paradigms for laboratory and clinical research. While some in arise through actions circulating hormones, other are independent estrogen, testosterone, or progesterone levels. Instead, these result sexual differentiation, process involves genetic epigenetic mechanisms, addition acute hormone actions. Sexual differentiation begins fertilization continues beyond menopause. It affects virtually every body system, resulting marked such areas as growth, lifespan, metabolism, immunity, all which can impact progression, treatment response, survival. These organismal level correlates at cellular level, thus, males females fundamentally differ their protections vulnerabilities cancer, from transformation stages spread, response treatment. Our goal this review cover robust exist core pathways make case inclusion biological variable finish discussion lab- clinic-based experimental design should be used when testing whether matters appropriate statistical models apply data analysis rigorous evaluations potential effects. facilitate evaluation order improve outcomes patients.

Language: Английский

Citations

280
ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma DOI Creative Commons
Shuo Chen,

Liwu Zhou,

Yang Wang

et al.

Cancer Cell International, Journal Year: 2020, Volume and Issue: 20(1)

Published: Jan. 30, 2020

Osteosarcoma (OS) is one of the most common malignant bone tumors. Plasmacytoma variant translocation 1 (PVT1) a well-known oncogenic long noncoding RNA (lncRNA). However, to date, regulatory mechanism PVT1 upregulation in OS remains unknown.qRT-PCR was carried out test expression level and ALKBH5. immunoprecipitation (RIP) pull-down assays were performed detect interaction with ALKBH5 YTHDF2. Methylated immune-precipitation (MeRIP) used examine N6-methyladenosine (m6A) modification transcript.In this study, we found that upregulated tissues cells significantly related clinical stage, tumor size, prognosis patients OS. Further investigation revealed demethylase could associate suppress its degradation. decreased m6A PVT1, thus inhibiting binding reader protein YTHDF2 PVT1. Functionally, ALKBH5-mediated promoted cell proliferation vitro growth vivo.Our study suggests contributes tumorigenesis.

Language: Английский

Citations

142
A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties DOI Creative Commons
Shuiqing Liu, Yan Sun, Yixuan Hou

et al.

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: Oct. 29, 2021

Cancer stem cells (CSCs) are considered as the major cause to tumor initiation, recurrence, metastasis, and drug resistance, driving poor clinical outcomes in patients. Long noncoding RNAs (lncRNAs) have emerged crucial regulators cancer development progression. However, limited lncRNAs involved CSCs been reported.The novel lncROPM (a regulator of phospholipid metabolism) breast (BCSCs) was identified by microarray validated qRT-PCR BCSCs from tissues. The significance evaluated two cohorts TANRIC database (TCGA-BRCA, RNAseq data). Gain- loss-of-function assays were performed examine role on both vitro vivo. regulatory mechanism investigated bioinformatics, RNA FISH, pull-down, luciferase reporter assay, actinomycin D treatment. PLA2G16-mediated metabolism determined UHPLC-QTOFMS system. Cells' chemosensitivity assessed CCK8 assay.LncROPM is highly expressed BCSCs. enhanced exists clinic tumors other solid positively correlates with malignant grade/stage prognosis studies show that required for maintenance properties Mechanistically, regulates PLA2G16 expression directly binding 3'-UTR increase mRNA stability. increased significantly promotes production free fatty acid, especially arachidonic acid BCSCs, thereby activating PI3K/AKT, Wnt/β-catenin, Hippo/YAP signaling, thus eventually involving stemness. Importantly, notably contribute chemo-resistance. Administration using therapeutic drugs such doxorubicin, cisplatin, or tamoxifen combined Giripladib (an inhibitor cytoplasmic phospholipase A2) can efficiently eliminate tumorigenesis.Our study highlights its target play roles sustaining BCSC may serve a biomarker cells. Targeting lncROPM-PLA2G16 signaling axis be strategy patients cancer.

Language: Английский

Citations

121
Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty DOI Creative Commons
Cédric Badowski, Bing He,

Lana X. Garmire

et al.

npj Precision Oncology, Journal Year: 2022, Volume and Issue: 6(1)

Published: June 21, 2022

Abstract Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated with cancer is partially due to lack reliable early detection methods and/or inaccurate diagnostic tools such certain protein biomarkers. Cell-free nucleic acids (cfNA) circulating long noncoding RNAs (lncRNAs) have been proposed a new class potential biomarkers for diagnosis. reported correlation between presence tumors and abnormal levels lncRNAs in blood patients has notably triggered worldwide interest among clinicians oncologists who actively investigating their potentials In this report, we review progress achieved (“the Good”) challenges encountered Bad”) development We report discuss performance more than 50 different emphasize numerous clinical applications Beauty”) including therapeutic targets agents, on top prognostic capabilities. This also summarizes best investigation provides useful guidelines scientists desire conducting own studies via RT-qPCR or Next Generation Sequencing (NGS).

Language: Английский

Citations

103
Long non-coding RNA mediated drug resistance in breast cancer DOI
Deepshikha Singh, Yehuda G. Assaraf, Rajesh N. Gacche

et al.

Drug Resistance Updates, Journal Year: 2022, Volume and Issue: 63, P. 100851 - 100851

Published: July 1, 2022

Language: Английский

Citations

96
The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer DOI Creative Commons

Jichuan Xu,

Jian Xu, Xinyuan Liu

et al.

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 14, 2022

Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts are known for their inability to encode proteins. NcRNAs consist a diverse range RNA species, including long non-coding (lncRNAs), have significant meaning epigenetic modification, post-transcriptional regulation target genes, molecular interference, etc. The dysregulation ncRNAs will mediate pathogenesis diseases, like cancer. Pancreatic cancer, as one most lethal malignancies in digestive system that is hard make definite diagnosis at an early clinicopathological stage with miserable prognosis. Therefore, identification potential and clinically applicable biomarker momentous improve overall survival rate positively ameliorate prognosis patients pancreatic carcinoma. LncRNAs kind exert multitudinous biological functions, act sponges, relying on microRNA response elements (MREs) competitively microRNAs (miRNAs), thereby attenuating degradation or inhibition miRNAs own downstream protein-coding also thus regulating initiation progression neoplasms. LncRNAs, emerge aforementioned function called competing endogenous (ceRNAs). Consequently, abundant research lncRNAs biomarkers critical significance diagnosis, targeted therapy, well monitoring

Language: Английский

Citations

90
Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review DOI
Md Sadique Hussain, Gaurav Gupta, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 252, P. 154908 - 154908

Published: Oct. 31, 2023

Language: Английский

Citations

54
Epigenetic modifications: Key players in cancer heterogeneity and drug resistance DOI Creative Commons
Hana Q. Sadida,

Alanoud Abdulla,

Sara Al Marzooqi

et al.

Translational Oncology, Journal Year: 2023, Volume and Issue: 39, P. 101821 - 101821

Published: Nov. 4, 2023

Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer treatment management. One major contributor to these challenges is epigenetic modifications - gene regulation that does not involve changes the DNA sequence itself but significantly impacts expression. As we elucidate phenomena, underscore role of regulating expression, contributing cellular diversity, driving adaptive can instigate therapeutic resistance. This review dissects essential methylation, histone modifications, chromatin remodeling illustrating their significant yet complex contributions biology. While offer potential avenues for intervention due reversible nature, interplay genetic cells presents unique must be addressed harness full potential. By critically analyzing current research landscape, identify knowledge gaps propose future directions, exploring therapies discussing translating concepts into treatments. comprehensive aims stimulate further aid developing innovative, patient-centered therapies. Understanding critical scientific advancement paves way towards improving patient outcomes fight against this formidable disease.

Language: Английский

Citations

52
Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications DOI
Ola Elazazy,

Heba M. Midan,

Reem K. Shahin

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 246, P. 154512 - 154512

Published: May 9, 2023

Language: Английский

Citations

50
Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer development DOI Creative Commons
Abdolmajid Ghasemian, Hadeel A. Omear,

Yaser Mansoori

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 29, 2023

Colorectal cancer (CRC) is one of the main fatal cancers. Cell signaling such as Janus kinase/signal transducer and activator transcription (JAK/STAT) substantially influences process gene expression cell growth. Long non-coding RNAs (lncRNAs) play regulatory roles in signaling, proliferation, fate. Hence, lncRNAs can be considered biomarkers The inhibitory or activating effects different on JAK/STAT pathway regulate proliferation tumor suppression. Additionally, immune responses which a role immunotherapy. Mechanisms CRC via regulation mainly include invasion, metastasis, apoptosis, adhesion, control inflammation. More profound findings are warranted to specifically target terms activation suppression hindering proliferation. Here, understand lncRNA cross-talk through pathway, we collected related vitro vivo data. Future insights may pave way for development novel diagnostic tools, therapeutic interventions, personalized treatment strategies patients.

Language: Английский

Citations

47