Neurochemical Research, Journal Year: 2021, Volume and Issue: 47(3), P. 517 - 530
Published: Oct. 20, 2021
Language: Английский
Progress in Retinal and Eye Research, Journal Year: 2020, Volume and Issue: 83, P. 100916 - 100916
Published: Oct. 17, 2020
The pathophysiology of glaucoma is complex, multifactorial and not completely understood. Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic nerve damage. In addition, age-related oxidative stress in the retina concurrently with chronic mechanical vascular crucial for initiation neurodegeneration. Oxidative closely related to cell senescence, mitochondrial dysfunction, excitotoxicity, neuroinflammation, which are involved progression. Accumulating evidence from animal models human ocular samples suggests a dysfunction para-inflammation ganglion layer head. Moreover, quite similar mechanisms anterior chamber could explain trabecular meshwork elevated IOP primary open-angle glaucoma. On other hand, surface disease due topical interventions most prominent visible consequence inflammation glaucoma, negative impact on filtering surgery failure, treatment efficacy, possibly segment. Consequently, appears as an outstanding eye where inflammatory changes be present various extents consequences along structure, posterior segment, visual pathway. Here we reviewed processes all structures back front beyond. Our approach was how necessary maintain homoeostasis, describe abnormal findings observed glaucomatous patients or models, supporting hypothesis dysregulation balance toward pro-inflammatory phenotype. Possible anti-inflammatory therapeutic approaches also discussed.
Language: Английский
Citations
313
Frontiers in Cellular Neuroscience, Journal Year: 2021, Volume and Issue: 15
Published: June 29, 2021
Microglia are the brain’s immunocompetent macrophages with a unique feature that allows surveillance of surrounding microenvironment and subsequent reactions to tissue damage, infection, or homeostatic perturbations. Thereby, microglia’s striking morphological plasticity is one their prominent characteristics categorization microglial cell function based on morphology well established. Frequently, automated classification phenotypes performed by using quantitative parameters. As this process typically limited few especially manually chosen criteria, relevant selection bias may compromise resulting classifications. In our study, we describe novel method evaluation convolutional neuronal network basis selected cells in addition classical We focused four morphologies, ramified, rod-like, activated amoeboid microglia within murine hippocampus cortex. The developed for was confirmed mouse model ischemic stroke which already known result activation affected brain regions. conclusion, machine learning can serve as time-saving objective post-mortem characterization changes healthy disease models, might also represent useful tool human autopsy samples.
Language: Английский
Citations
142
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(1), P. 15 - 34
Published: Oct. 16, 2024
Neuroprotection is a proactive approach to safeguarding the nervous system, including brain, spinal cord, and peripheral nerves, by preventing or limiting damage nerve cells other components. It primarily defends central system against injury from acute progressive neurodegenerative disorders. Oxidative stress, an imbalance between body's natural defense mechanisms generation of reactive oxygen species, crucial in developing neurological Due its high metabolic rate consumption, brain particularly vulnerable oxidative stress. Excessive ROS damages essential biomolecules, leading cellular malfunction neurodegeneration. Several disorders, Alzheimer's, Parkinson's, Amyotrophic lateral sclerosis, multiple ischemic stroke, are associated with Understanding impact stress these conditions for new treatment methods. Researchers exploring using antioxidants molecules mitigate aiming prevent slow down progression diseases. By understanding intricate interplay scientists hope pave way innovative therapeutic preventive approaches, ultimately improving individuals' living standards.
Language: Английский
Citations
45
Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)
Published: April 29, 2021
Abstract Increasing life expectancy has led to an aging population, which consequently increased the prevalence of dementia. Alzheimer's disease (AD), most common form dementia worldwide, is estimated make up 50–80% all cases. AD cases are expected reach 131 million by 2050, and this increasing will critically burden economies health systems in next decades. There currently no treatment that can stop or reverse progression. In addition, late diagnosis constitutes a major obstacle effective management. Therefore, improved diagnostic tools new treatments for urgently needed. review, we investigate describe both well-established recently discovered biomarkers could potentially be used detect at early stages allow monitoring Proteins such as NfL, MMPs, p-tau217, YKL-40, SNAP-25, VCAM-1, Ng / BACE some promising because their successful use tools. explore recent molecular strategies therapeutic approach nanomedicine-based technologies, target drugs brain serve devices tracking progression biomarkers. State-of-the-art nanoparticles, polymeric, lipid, metal-based, being widely investigated potential improve effectiveness conventional novel compounds treating AD. The studies on these nanodevices deeply explained discussed review. Graphic
Language: Английский
Citations
87
Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15
Published: Aug. 31, 2021
Intercellular communication in the central nervous system (CNS) is essential for brain growth, development, and homeostasis maintenance and, when dysfunctional, involved occurrence development of neurodegenerative diseases. Increasing evidence indicates that extracellular vesicles, especially exosomes, are critical mediators intercellular signal transduction. Under physiological pathological conditions, neural cells secret exosomes with influence many factors. These can carry specific proteins, lipids, nucleic acids, other bioactive substances to recipient regulate their function. Depending on CNS environment, as well origin or status parental cells, mediate a variety different effects, including synaptic plasticity, nutritional metabolic support, nerve regeneration, inflammatory response, anti-stress effect, cellular waste disposal, propagation toxic components, playing an important role health This review will discuss possible roles both physiologic conditions.
Language: Английский
Citations
84
Frontiers in Molecular Neuroscience, Journal Year: 2021, Volume and Issue: 14
Published: Oct. 5, 2021
Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia have pro-inflammatory phenotype anti-inflammatory phenotype. Activated activated can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs) circular (circRNAs), two groups of (ncRNAs), function as competing endogenous (ceRNAs) impair microRNA (miRNA) inhibition on targeted messenger (mRNAs). LncRNAs circRNAs are involved various disorders. In this review, we summarized that lncRNAs participate dysfunction, astrocyte neuron damage, inflammation. Thereby, positively or negatively regulate diseases, including spinal cord injury (SCI), traumatic brain (TBI), ischemia-reperfusion (IRI), stroke, neuropathic pain, epilepsy, Parkinson’s disease (PD), multiple sclerosis (MS), Alzheimer’s (AD). Besides, also found a lncRNA/circRNA-miRNA-mRNA regulatory network mediated Through hope cast light mechanisms diseases provide new insights for treatment.
Language: Английский
Citations
80
Food and Chemical Toxicology, Journal Year: 2021, Volume and Issue: 153, P. 112283 - 112283
Published: May 21, 2021
Language: Английский
Citations
76
Cells, Journal Year: 2021, Volume and Issue: 10(3), P. 565 - 565
Published: March 5, 2021
Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps axons in multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic support to neurons. In last few years, impact of OL dysfunction myelin damage has progressively received more attention now considered be a major contributing factor neurodegeneration several neurological diseases, including amyotrophic lateral sclerosis (ALS). Upon injury, oligodendrocyte precursor cells (OPCs) adult nervous tissue sustain generation new OLs for reconstitution, but this spontaneous regeneration process fails successfully counteract damage. Of note, functions OPCs exceed formation repair myelin, also involve trophic capability exert an immunomodulatory role, which are particularly relevant context neurodegeneration. review, we deeply analyze dysfunctional ALS pathogenesis. The possible mechanisms underlying degeneration, defective OPC maturation, impairment energy supply motor neurons (MNs) have been examined provide insights on future therapeutic interventions. On basis, discuss potential utility molecules, based their remyelinating or enhance metabolism.
Language: Английский
Citations
61
Acta Pharmacologica Sinica, Journal Year: 2021, Volume and Issue: 43(1), P. 1 - 9
Published: March 26, 2021
Language: Английский
Citations
58
Biomolecules, Journal Year: 2022, Volume and Issue: 12(4), P. 597 - 597
Published: April 18, 2022
Glutamate is the major excitatory neurotransmitter in central nervous system and intricately linked to learning memory. Its activity depends on expression of AMPA NMDA receptors amino transporters neurons glial cells. prevent excess accumulation glutamate synapses, which can lead aberrant synaptic signaling, excitotoxicity, or cell death. Neuroinflammation occur acutely after surgical trauma contributes development perioperative neurocognitive disorders, are characterized by impairment multiple cognitive domains. In this review, we aim examine how handling glutamatergic function affected neuroinflammation their contribution impairment. We will first summarize current data regarding neurotransmission, its receptors, regulation trafficking. then impact inflammation focusing changes cells effect cytokines. Finally, discuss these context implications they have for disorders.
Language: Английский
Citations
51