Inflammation and aging: signaling pathways and intervention therapies

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 8, 2023

Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical

Language: Английский

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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 71, P. 101422 - 101422

Published: Aug. 13, 2021

Language: Английский

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Personal aging markers and ageotypes revealed by deep longitudinal profiling

Nature Medicine, Journal Year: 2020, Volume and Issue: 26(1), P. 83 - 90

Published: Jan. 1, 2020

Language: Английский

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Neuroinflammation in Alzheimer’s Disease

Biomedicines, Journal Year: 2021, Volume and Issue: 9(5), P. 524 - 524

Published: May 7, 2021

Alzheimer's disease (AD) is a neurodegenerative associated with human aging. Ten percent of individuals over 65 years have AD and its prevalence continues to rise increasing age. There are currently no effective modifying treatments for AD, resulting in increasingly large socioeconomic personal costs. Increasing age an increase low-grade chronic inflammation (inflammaging) that may contribute the process AD. Although exact mechanisms remain unclear, aberrant elevation reactive oxygen nitrogen species (RONS) levels from several endogenous exogenous processes brain not only affect cell signaling, but also trigger cellular senescence, inflammation, pyroptosis. Moreover, compromised immune privilege allows infiltration peripheral cells infectious agents play role. Additionally, meta-inflammation as well gut microbiota dysbiosis drive neuroinflammatory process. Considering inflammatory/immune pathways dysregulated parallel cognitive dysfunction elucidating relationship between central nervous system facilitate development safe therapy We discuss some current ideas on inflammaging appear summarize details few immunomodulatory strategies being developed selectively target detrimental aspects neuroinflammation without affecting defense against pathogens tissue damage.

Language: Английский

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Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Cancer Discovery, Journal Year: 2022, Volume and Issue: 13(2), P. 410 - 431

Published: Oct. 27, 2022

Abstract Cellular senescence is a stress response that activates innate immune cells, but little known about its interplay with the adaptive system. Here, we show senescent cells combine several features render them highly efficient in activating dendritic (DC) and antigen-specific CD8 T cells. This includes release of alarmins, activation IFN signaling, enhanced MHC class I machinery, presentation senescence-associated self-peptides can activate In context cancer, immunization cancer elicits strong antitumor protection mediated by DCs Interestingly, this superior to undergoing immunogenic cell death. Finally, induction human primary also augments their ability autologous tumor-infiltrating lymphocytes. Our study indicates be exploited develop protective CD8-dependent responses. Significance: shows are endowed high potential—superior gold standard We harness these properties trigger See related article Chen et al., p. 432. highlighted Issue feature, 247

Language: Английский

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Senescence mechanisms and targets in the heart

Cardiovascular Research, Journal Year: 2021, Volume and Issue: 118(5), P. 1173 - 1187

Published: May 5, 2021

Abstract Cellular senescence is a state of irreversible cell cycle arrest associated with ageing. Senescence different cardiac types can direct the pathophysiology cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, and fibrosis. While age-related telomere shortening represents major cause replicative senescence, senescent also be induced by oxidative stress, metabolic dysfunction, epigenetic regulation, among other stressors. It critical that we understand molecular pathways lead to cellular consequences in order develop new therapeutic approaches treat CVD. In this review, discuss mechanisms explore how (including cardiomyocytes, endothelial cells, fibroblasts, vascular smooth muscle valve interstitial cells) CVD, highlight potential target prevent or

Language: Английский

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Interconnections between Inflammageing and Immunosenescence during Ageing

Cells, Journal Year: 2022, Volume and Issue: 11(3), P. 359 - 359

Published: Jan. 21, 2022

Acute inflammation is a physiological response to injury or infection, with cascade of steps that ultimately lead the recruitment immune cells clear invading pathogens and heal wounds. However, chronic arising from continued presence initial trigger, dysfunction signalling and/or effector pathways, harmful health. While successful ageing in older adults, including centenarians, associated low levels inflammation, elevated increases risk poor health death. Hence has been described as one seven pillars ageing. Age-associated sterile, chronic, low-grade commonly termed inflammageing-it not simply consequence increasing chronological age, but also marker biological ageing, multimorbidity, mortality risk. inflammageing was initially thought be caused by "continuous antigenic load stress", reports last two decades describe much more complex phenomenon involving cellular senescence system. In this review, we explore some main sources consequences context immunosenescence highlight potential interventions. particular, assess contribution age-associated identify patterns pro- anti-inflammatory markers characteristic inflammageing, alterations system finally ways diet, exercise, pharmacological interventions can reduce thus, improve later life

Language: Английский

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miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 70, P. 101374 - 101374

Published: May 31, 2021

Language: Английский

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Targeting immune dysfunction in aging

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 70, P. 101410 - 101410

Published: July 17, 2021

Human aging is a multifactorial phenomenon that affects numerous organ systems and cellular processes, with the immune system being one of most dysregulated. Immunosenescence, gradual deterioration system, inflammaging, chronic inflammatory state persists in elderly, are among plethora changes occur during aging. Almost all populations cells change age terms numbers and/or activity. These alterations general highly detrimental, resulting an increased susceptibility to infections, reduced healing abilities, altered homeostasis promote emergence age-associated diseases such as cancer, diabetes, other associated inflammation. Thanks recent developments, several strategies have been proposed target central immunological processes or specific subpopulations affected by therapeutic approaches could soon be applied clinic slow down even reverse age-induced order rejuvenate prevent reduce impact various diseases. Due its systemic nature interconnection body, attractive for intervention because relatively targeted modifications small set potential improve health multiple systems. Therefore, anti-aging targeting therapies represent potent approach improving healthspan. Here, we review major components summarize current immune-targeting context discuss future directions field rejuvenation.

Language: Английский

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Immunosenescence, aging and successful aging

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 2, 2022

Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative tumors, cardiovascular autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism association with aging successful aging, effects on are not revealed obviously. In order to provide theoretical basis for preventing or controlling effectively achieve we conducted review found that changes aging-related phenotypes, deterioration organ function alterations cell subsets participated process had great occurrence development diseases.

Language: Английский

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