Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 8, 2022

Abstract Recently, mesenchymal stromal cells (MSCs) and their derivative exosome have become a promising approach in the context of liver diseases therapy, particular, acute failure (ALF). In addition to differentiation into hepatocytes vivo, which is partially involved regeneration, MSCs support regeneration as result appreciated competencies, such antiapoptotic, immunomodulatory, antifibrotic, also antioxidant attributes. Further, MSCs-secreted molecules inspire hepatocyte proliferation facilitating damaged tissue recovery ALF. Given these properties, various MSCs-based approaches evolved resulted encouraging outcomes ALF animal models displayed safety modest efficacy human studies, providing new avenue for therapy. Irrespective MSCs-derived exosome, strategies include administration native MSCs, genetically modified pretreated delivery using biomaterials, combination with other therapeutic or modalities. Herein, we will deliver an overview regarding effects exosomes As well, discuss recent progress preclinical clinical studies current challenges therapies ALF, special focus on vivo reports.

Language: Английский

---

Advances in Therapeutic Applications of Extracellular Vesicles

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 3285 - 3307

Published: June 1, 2023

Abstract: Extracellular vesicles (EVs) are nanoscale bilayer phospholipid membrane released by cells. Contained large molecules such as nucleic acid, protein, and lipid, EVs an integral part of cell communication. The contents vary based on the source play important role in both pathological physiological conditions. can be used drugs or targets disease treatment, changes indicate progression diseases. In recent years, with continuous exploration structure, characteristics, functions EVs, potential engineered for drug delivery therapy being constantly explored. This review provides a brief overview characteristics summarizes advanced application outlook prospect it. It is our hope that this will increase understanding current development medical applications help us overcome future challenges. Keywords: extracellular vesicle, nanotherapeutic, diagnosis, exosome, advances

Language: Английский

---

Injectable hydrogels for sustained delivery of extracellular vesicles in cartilage regeneration

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 355, P. 685 - 708

Published: Feb. 19, 2023

Extracellular vesicles (EVs) are a population of small secreted by essentially all cell types, containing wide variety biological macromolecules. Due to their intrinsic capabilities for efficient intercellular communication, they involved in various aspects cellular functioning. In the past decade, EVs derived from stem cells attracted interest field regenerative medicine. Owing properties, have great potential use tissue repair, particular tissues with limited such as cartilage. The maintenance articular cartilage is dependent on precarious balance many different components that can be disrupted onset prevalent rheumatic diseases. However, while strong mechanical properties withstand movement and heavy loads years, it virtually incapable repairing itself after damage has occurred. Stem cell-derived (SC-EVs) transport proteins nucleic acids parental recipient cells, thereby promoting healing. Many possible pathways through which SC-EVs execute function been reported, but likely there still numerous other unknown. This review discusses preclinical studies investigating intra-articular injections free SC-EVs, which, often chondrogenesis repair vivo, showed recurring limitation need multiple administrations achieve sufficient regeneration. Potentially, this drawback overcome making an EV delivery platform capable sustainably releasing over time. With remarkable versatility favourable chemical, hydrogels facilitate release profile encapsulating porous structure. Ideally, optimal formed in-situ, means injectable hydrogel administered directly into affected joint. Relevant research fulfilling these criteria discussed detail, including steps taken before sustained applied context regeneration clinic.

Language: Английский

---

The role of extracellular vesicles in periodontitis: pathogenesis, diagnosis, and therapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 11, 2023

Periodontitis is a prevalent disease and one of the leading causes tooth loss. Biofilms are initiating factor periodontitis, which can destroy periodontal tissue by producing virulence factors. The overactivated host immune response primary cause periodontitis. clinical examination tissues patient’s medical history mainstays periodontitis diagnosis. However, there lack molecular biomarkers that be used to identify predict activity precisely. Non-surgical surgical treatments currently available for although both have drawbacks. In practice, achieving ideal therapeutic effect remains challenge. Studies revealed bacteria produce extracellular vesicles (EVs) export proteins cells. Meanwhile, cells EVs pro- or anti-inflammatory effects. Accordingly, play critical role in pathogenesis Recent studies also presented content composition saliva gingival crevicular fluid (GCF) serve as possible diagnostic indicators. addition, indicated stem cell may encourage regeneration. this article, we mainly review discuss their potential.

Language: Английский

---

The Progress in Bioprinting and Its Potential Impact on Health-Related Quality of Life

Bioengineering, Journal Year: 2023, Volume and Issue: 10(8), P. 910 - 910

Published: Aug. 1, 2023

The intensive development of technologies related to human health in recent years has caused a real revolution. transition from conventional medicine personalized medicine, largely driven by bioprinting, is expected have significant positive impact on patient's quality life. This article aims conduct systematic review bioprinting's potential health-related A literature search was conducted accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. comprehensive undertaken using PubMed, Scopus, Google Scholar, ScienceDirect databases between 2019 2023. We identified some most benefits bioprinting improve life: part production; saving millions lives; reducing rejection risks after transplantation; accelerating process skin tissue regeneration; homocellular model generation; precise fabrication accurate specifications; eliminating need organs donor, thus patient waiting time. In addition, these advances greatly benefit cancer treatment other research, offering medical solutions tailored each individual that could increase chance survival significantly their overall well-being. Although advancements are still research stage, encouraging results scientific studies suggest they verge being integrated into treatment. progress power revolutionize healthcare, promising profound improving life potentially transforming field healthcare.

Language: Английский

---