Royal Society of Chemistry eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 27
Published: July 19, 2024
This
chapter
primarily
provides
a
succinct
introduction
to
the
key
developments
in
smart
injectable
hydrogels.
The
focal
points
include
their
diverse
categories,
inherent
advantages
and
distinguishing
features.
further
elucidates
properties
of
hydrogels
discusses
mechanisms
employed
for
formation
these
through
crosslinking
methods.
latter
part
this
highlights
applications
medical
field.
can
serve
as
an
essential
resource
those
seeking
understand
fundamental
features
multifaceted
potential
hydrogel
materials.
It
ensures
that
readers
will
gain
thorough
understanding
versatile
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: June 17, 2023
Abstract
Regeneration
is
a
complex
process
affected
by
many
elements
independent
or
combined,
including
inflammation,
proliferation,
and
tissue
remodeling.
Stem
cells
class
of
primitive
with
the
potentiality
differentiation,
regenerate
self‐replication,
multidirectional
immunomodulatory
functions.
their
cytokines
not
only
inextricably
linked
to
regeneration
ectodermal
skin
tissues,
but
also
can
be
used
for
treatment
variety
chronic
wounds.
produce
exosomes
in
paracrine
manner.
cell
play
an
important
role
regeneration,
repair,
accelerated
wound
healing,
biological
properties
which
are
similar
stem
cells,
while
safer
more
effective.
Skin
bone
tissues
critical
organs
body,
essential
sustaining
life
activities.
The
weak
repairing
ability
leads
pronounced
impact
on
quality
patients,
could
alleviated
treatment.
However,
there
obstacles
that
trough
improved
bioavailability.
This
paper
summarizes
applications
mechanisms
healing.
We
propose
new
ways
utilizing
through
different
nanoformulations,
liposomes
nanoliposomes,
polymer
micelles,
microspheres,
hydrogels,
scaffold
microneedles,
improve
use
healing
regeneration.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2(3)
Published: March 13, 2024
Abstract
Orthopedic
diseases,
such
as
osteoarthritis
and
fractures,
place
a
significant
burden
on
individuals
healthcare
systems
worldwide.
Extracellular
vesicles
(EVs),
which
are
membrane‐derived
particles,
have
emerged
novel
tool
in
the
field
of
orthopedics.
EVs
play
crucial
role
diagnosing,
regenerating,
treating
orthopedic
diseases.
In
terms
diagnosis,
serve
potential
biomarkers,
carrying
unique
donor
cell
information
circulating
effectively
bodily
fluids.
Specific
biomolecules
within
EVs,
including
proteins,
nucleic
acids,
microRNAs,
hold
promise
biological
markers
for
early
detection
monitoring
shown
promoting
bone
cartilage
regeneration.
They
can
enhance
tissue
regeneration
by
stimulating
various
stem
cells
to
proliferate,
migrate,
differentiate
into
mature
chondrocytes
osteocytes.
also
target
specific
tissues,
making
them
attractive
candidates
drug
delivery
efficiently
deliver
therapeutic
cargo,
anti‐inflammatory
agents
growth
factors,
affected
sites,
enhancing
treatment
efficacy
while
minimizing
toxicity
adverse
effects.
conclusion,
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The
utilization
of
extracellular
vesicles
(EVs)
in
wound
healing
has
been
well-documented.However,
the
direct
administration
free
EVs
via
subcutaneous
injection
at
sites
may
result
rapid
dissipation
bioactive
components
and
diminished
therapeutic
efficacy.Functionalized
hydrogels
provide
effective
protection,
as
well
ensure
sustained
release
bioactivity
during
process,
making
them
an
ideal
candidate
material
for
delivering
EVs.In
this
review,
we
introduce
mechanisms
by
which
accelerate
healing,
then
elaborate
on
construction
strategies
engineered
EVs.Subsequently,
discuss
synthesis
application
delivery
systems
to
enhance
complicated
healing.Furthermore,
face
wounds,
functionalized
with
specific
microenvironment
regulation
capabilities,
such
antimicrobial,
anti-inflammatory,
immune
regulation,
used
loading
EVs,
potential
approaches
addressing
these
challenges.Ultimately,
deliberate
future
trajectories
outlooks,
offering
a
fresh
viewpoint
advancement
artificial
intelligence
(AI)-energized
materials
3D
bio-printed
multifunctional
hydrogel-based
dressings
biomedical
applications.
Abstract
With
the
aging
and
obesity
era,
increasing
incidence
of
diabetes
diabetic
complications,
especially
non‐healing
wounds,
imposes
a
serious
economic
burden
on
both
patients
society.
The
complex
microenvironments,
including
hyperglycemia,
bacterial
infection,
ischemia,
nerve
damage,
lead
to
prolonged
inflammation
proliferation
phase
wounds.
Mesenchymal
stem
cell‐derived
small
extracellular
vesicles
(MSC‐sEVs),
which
contain
rich
variety
therapeutic
molecules,
have
been
chased
for
decades
because
their
potential
roles
in
cellular
communication,
tissue
regeneration,
drug
delivery.
As
powerful
tools
controlled‐sustained
release
sEVs,
biocompatible
hydrogels
applied
wide
range
biomedical
applications.
Herein,
we
first
summarize
pathological
features
such
as
angiopathy,
neuropathy,
immune
cell
dysfunction.
Then,
discuss
biological
properties,
performance,
stability
pure
MSC‐sEVs.
After
that,
components,
application
patterns,
responsiveness
hydrogels.
Next,
loading
avenues
MSC‐sEVs
into
hydrogel,
behaviors
sEVs
from
hydrogels,
influence
crosslinking
method
hydrogel‐sEV
composites.
Finally,
provide
an
overview
current
applications
loaded
with
novel
cell‐free
engineering
system
managing
wounds
propose
critical
unsolved
issues.
This
review
is
expected
meaningful
guidance
developing
wound
management.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2243 - 2260
Published: March 25, 2024
Cartilage
repair
has
been
a
significant
challenge
in
orthopedics
that
not
yet
fully
resolved.
Due
to
the
absence
of
blood
vessels
and
almost
cell-free
nature
mature
cartilage
tissue,
limited
ability
resulted
socioeconomic
pressures.
Polysaccharide
materials
have
recently
widely
used
for
tissue
due
their
excellent
cell
loading,
biocompatibility,
chemical
modifiability.
They
also
provide
suitable
microenvironment
regeneration.
In
this
Review,
we
summarize
techniques
clinically
repair,
focusing
on
polysaccharides,
polysaccharides
differences
between
these
other
materials.
addition,
engineering
strategies
an
outlook
developing
next-generation
regeneration
from
polysaccharides.
This
Review
will
theoretical
guidance
polysaccharide-based
with
clinical
applications
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
design
strategies
for
external
stimuli-driven
hydrogels
with
in
situ
catalytic
processes.
It
highlights
precise
control
over
the
properties,
elucidating
regulatory
mechanisms
and
deepening
understanding
of
applications.
Journal of Extracellular Vesicles,
Journal Year:
2025,
Volume and Issue:
14(3)
Published: March 1, 2025
ABSTRACT
Mesenchymal
stem/stromal
cells
(MSCs)
are
a
valuable
source
of
paracrine
factors,
as
they
have
remarkable
secretory
capacity,
and
there
is
sizeable
knowledge
base
to
develop
industrial
clinical
production
protocols.
Promising
cell‐free
approaches
for
tissue
regeneration
immunomodulation
driving
research
towards
secretome
applications,
among
which
extracellular
vesicles
(EVs)
steadily
gaining
attention.
However,
the
manufacturing
application
EVs
limited
by
insufficient
yields,
gaps,
low
standardization.
Facing
these
limitations,
hydrogels
represent
versatile
three‐dimensional
(3D)
culture
platform
that
can
incorporate
matrix
(ECM)
components
mimic
natural
stem
cell
environment
in
vitro;
via
niche‐mimicking
properties,
regulate
MSCs’
morphology,
adhesion,
proliferation,
differentiation
secretion
capacities.
impact
hydrogel's
architectural,
biochemical
biomechanical
properties
on
remains
poorly
understood,
field
still
its
infancy
interdependency
parameters
compromises
comparability
studies.
Therefore,
this
review
summarizes
discusses
reported
effects
hydrogel
encapsulation
MSC‐EVs.
Considering
cell‐material
interactions
overall
activity
MSCs,
we
identify
persistent
challenges
from
standardization
process
control,
outline
future
paths
research,
such
synergic
use
bioreactors
enhance
MSC‐EV
generation.
