Tissue-Specific Diversity of Nuclear-Encoded Mitochondrial Genes Related to Lipid and Carbohydrate Metabolism in Buffalo

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

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Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells

Cells, Journal Year: 2019, Volume and Issue: 8(10), P. 1241 - 1241

Published: Oct. 11, 2019

: Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide. Reactive oxygen species (ROS), as potent oxidants in cells, have been shown to promote development NAFLD. Previous studies reported that for ROS-induced cellular oxidative stress, promoting lipid droplet (LD) accumulation associated with antioxidation process. However, regulatory role LDs relieving stress poorly understood. Here, we showed Perilipin 5 (PLIN5), a key LD protein related mitochondria–LD contact, reduced ROS levels and improved mitochondrial function HepG2 cells. Both mRNA PLIN5 were significantly increased cells hydrogen peroxide or lipopolysaccharide (LPS) treatment (p < 0.05). Additionally, overexpression promoted formation up-regulated function-related genes such COX CS. Knockdown PLIN5, meanwhile, opposite effects. Furthermore, identified expression via JNK-p38-ATF pathway. This study shows up-regulation kind survival strategy response stress. can be potential therapeutic target

Language: Английский

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Mitochondrial Gene Expression and Beyond—Novel Aspects of Cellular Physiology

Cells, Journal Year: 2019, Volume and Issue: 9(1), P. 17 - 17

Published: Dec. 19, 2019

Mitochondria are peculiar organelles whose proper function depends on the crosstalk between two genomes, mitochondrial and nuclear. The human genome (mtDNA) encodes only 13 proteins; nevertheless, its expression is essential for cellular homeostasis, as mtDNA-encoded proteins constituents of respiratory complexes. In addition, mtDNA results in production RNA molecules, which influence cell physiology once released from mitochondria into cytoplasm. As a result, dysfunctions may lead to pathologies humans. Here, we review mechanisms gene with focus recent findings field. We summarize complex turnover transcripts present an increasing body evidence indicating new functions transcripts. discuss regulation different contexts, focusing stress conditions. Finally, highlight importance emerging aspects health disease.

Language: Английский

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Simultaneous imaging of lysosomal and mitochondrial viscosity under different conditions using a NIR probe

Sensors and Actuators B Chemical, Journal Year: 2020, Volume and Issue: 326, P. 128954 - 128954

Published: Sept. 25, 2020

Language: Английский

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Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

Journal of Molecular Medicine, Journal Year: 2020, Volume and Issue: 99(1), P. 57 - 73

Published: Nov. 17, 2020

Language: Английский

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