Dyes and Pigments, Journal Year: 2023, Volume and Issue: 216, P. 111308 - 111308
Published: April 13, 2023
Language: Английский
Dyes and Pigments, Journal Year: 2023, Volume and Issue: 216, P. 111308 - 111308
Published: April 13, 2023
Language: Английский
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(4), P. 1738 - 1861
Published: Feb. 14, 2024
The microenvironment is indispensable for functionality of various biomacromolecules, subcellular compartments, living cells, and organisms. In particular, physical properties within the biological could exert profound effects on both cellular physiology pathology, with parameters including polarity, viscosity, pH, other relevant factors. There a significant demand to directly visualize quantitatively measure fluctuation in spatiotemporal resolution. To satisfy this need, analytical methods based fluorescence probes offer great opportunities due facile, sensitive, dynamic detection that these molecules enable varying settings from vitro samples live animal models. Herein, we focus types small molecule fluorescent measurement microenvironment, mechanical force, temperature, electron potential. For each parameter, primarily describe chemical mechanisms underlying how are correlated changes signals. This review provides an overview perspective development environment, expand knowledge process, enrich diagnostic tools human diseases.
Language: Английский
Citations
116Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 383, P. 133510 - 133510
Published: Feb. 13, 2023
A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric response toward hypochlorite (ClO-) with the LOD (0.082 μM), and "turn-on" to viscosity changes. Due low cytotoxicity good biocompatibility, used monitor hypochlorous acid in mitochondria of living cells zebrafish.
Language: Английский
Citations
91Talanta, Journal Year: 2023, Volume and Issue: 259, P. 124529 - 124529
Published: April 7, 2023
Language: Английский
Citations
57Talanta, Journal Year: 2024, Volume and Issue: 272, P. 125825 - 125825
Published: Feb. 23, 2024
Language: Английский
Citations
20ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
This paper presents the development of near-infrared (NIR) fluorescent probes,
Language: Английский
Citations
2Chemistry - A European Journal, Journal Year: 2020, Volume and Issue: 27(23), P. 6880 - 6898
Published: Dec. 19, 2020
Abstract Viscosity, as a vital microenvironment parameter, is tightly associated with multitudinous cellular processes and diseases. Recently, precise visualization of viscosity has started to arouse more interest. However, owing the complicated character, it still huge challenge directly observe in living systems. In this regard, mounting fluorescence probes are being increasingly fabricated map inside live cells small animals. minireview, viscosity‐sensitive molecular fluorescent used bioimaging comprehensively summarized, mainly focusing on last three years. Moreover, current challenges opportunities for development viscosity‐specific will be discussed.
Language: Английский
Citations
134Chemical Communications, Journal Year: 2021, Volume and Issue: 57(36), P. 4376 - 4379
Published: Jan. 1, 2021
A
mitochondria-targeted
near-infrared
fluorescent
probe
Language: Английский
Citations
100Sensors and Actuators B Chemical, Journal Year: 2022, Volume and Issue: 359, P. 131594 - 131594
Published: Feb. 18, 2022
Language: Английский
Citations
47Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(6), P. 3544 - 3549
Published: Feb. 6, 2023
Aberrant mitochondrial viscosity is closely associated with many diseases and cellular malfunctions. Thus, the development of reliable methods for monitoring variations has attracted considerable attention. Herein, through stepwise structural modulation dihydroxanthene fluorophore (DHX), we developed three NIR fluorescent probes, named DHX-V-1-3, detecting viscosity. Among them, DHX-V-3 displayed highest signal-to-noise ratio (67-fold) outstanding selectivity showed excellent mitochondria targeting immobilization ability. At level, probe was successfully applied to image in live cells upon treatment lipopolysaccharide (LPS) or nystatin. Moreover, benefiting from its emission increased depth tissue imaging, demonstrated ability visualize LPS-treated mice.
Language: Английский
Citations
42Developmental Cell, Journal Year: 2024, Volume and Issue: 59(4), P. 517 - 528.e3
Published: Jan. 24, 2024
Language: Английский
Citations
10