Cellular Red-Ox system in health and disease: The latest update

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114606 - 114606

Published: March 28, 2023

Cells are continually exposed to reactive oxygen species (ROS) generated during cellular metabolism. Apoptosis, necrosis, and autophagy biological processes involving a feedback cycle that causes ROS molecules induce oxidative stress. To adapt exposure, living cells develop various defense mechanisms neutralize use as signaling molecule. The redox networks combine pathways regulate cell metabolism, energy, survival, death. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) essential antioxidant enzymes required for scavenging in compartments response stressful situations. Among the non-enzymatic defenses, vitamin C, (GSH), polyphenols, carotenoids, E, etc., also essential. This review article describes how produced byproducts of oxidation/reduction (redox) antioxidants system is directly or indirectly engaged ROS. In addition, we used computational methods determine comparative profile binding energies several with enzymes. analysis demonstrates high affinity their structures.

Language: Английский

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Towards load-bearing biomedical titanium-based alloys: From essential requirements to future developments

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101277 - 101277

Published: March 8, 2024

The use of biomedical metallic materials in research and clinical applications has been an important focus a significant area interest, primarily owing to their role enhancing human health extending lifespan. This article, particularly on titanium-based alloys, explores exceptional properties that can address bone issues amid the growing challenges posed by aging population. Although stainless steel, magnesium-based cobalt-based other are commonly employed medical applications, limitations such as toxic elements, high elastic modulus, rapid degradation rates limit widespread applications. Therefore, alloys have emerged top-performing materials, gradually replacing counterparts various article extensively examines highlights along with in-depth discussion currently utilized inherent limitations. To begin with, essential requirements for load-bearing biomaterials introduced. Then, summarized compared. Afterward, microstructure, properties, preparations explored. Furthermore, surface modification methods discussed enhance biocompatibility, wear resistance corrosion resistance. Finally, proposes development path conjunction additive manufacturing novel alloy nitinol.

Language: Английский

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Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease

BioFactors, Journal Year: 2024, Volume and Issue: 50(4), P. 693 - 708

Published: Jan. 16, 2024

Abstract Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological have shown limited efficacy are associated with side effects. Approaches focusing on the early interference pathways, before activation of broad processes, could be promising slow down symptomatic progression disease. Curcumin—an integral component traditional medicine in numerous cultures worldwide—has garnered interest as AD treatment. research indicates that curcumin may exhibit potential pathologies, attributed its potent anti‐inflammatory antioxidant properties. Additionally, derivatives demonstrated an ability modulate cellular pathways via epigenetic mechanisms. This article aims raise awareness neuroprotective properties curcuminoids provide benefits AD. paper provides comprehensive overview against signaling involved summarizes recent evidence biological efficiency curcumins vivo.

Language: Английский

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Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator

Molecules, Journal Year: 2021, Volume and Issue: 26(11), P. 3255 - 3255

Published: May 28, 2021

Deferoxamine B is an outstanding molecule which has been widely studied in the past decade for its ability to bind iron and many other metal ions. The versatility of this chelator makes it suitable a number medicinal analytical applications, from well-known chelation therapy most recent use sensor devices. three bidentate hydroxamic functional groups deferoxamine are centerpiece binding ability, allows formation stable complexes with transition, lanthanoid actinoid In addition ferric ion, fact, more than 20 different b have characterized terms their chemical speciation solution. addition, availability terminal amino group, often not involved complexation, opens way modification functionalization. This review aims collect summarize available data concerning complex-formation equilibria solutions A general overview progress applications over also discussed, including treatment overload-associated diseases, clinical against cancer neurodegenerative disorders role as diagnostic tool.

Language: Английский

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Role of metals in Alzheimer’s disease

Metabolic Brain Disease, Journal Year: 2021, Volume and Issue: 36(7), P. 1627 - 1639

Published: July 27, 2021

Language: Английский

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Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

Medicines, Journal Year: 2020, Volume and Issue: 7(8), P. 45 - 45

Published: July 30, 2020

Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth development of humans, their deficiency can result in serious diseases. Their interaction is nutritional, physiological, pharmacological toxicological interest, with major implications health disease. Millions people using pharmaceutical nutraceutical preparations these two nutrients, including ferrous ascorbate treatment iron anaemia combination deferoxamine increasing excretion overload. The main function use vitamin C its antioxidant activity against reactive oxygen species, which implicated many diseases free radical pathology, biomolecular-, cellular- tissue damage-related diseases, as well cancer ageing. Ascorbic metabolites, anion oxalate, have metal binding capacity bind iron, copper other metals. biological roles a affected by complexation, particular following copper. Ascorbate forms complex Fe3+ followed reduction to Fe2+, may potentiate production. clinical activities ascorbate–iron also be preparations. Optimal therapeutic strategies improved efficacy lower toxicity could designed ascorbate, iron–ascorbate different conditions based on absorption, distribution, metabolism, excretion, (ADMET), pharmacokinetic, redox properties. Similar relation interactions food components pharmaceuticals, aspects concerning personalized medicine.

Language: Английский

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Role of Flavonoids in the Treatment of Iron Overload

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: July 5, 2021

Iron overload, a high risk factor for many diseases, is seen in almost all human chronic and common diseases. chelating agents are often used treatment but, at present, most of these have narrow scope application, obvious side effects, other disadvantages. Recent studies shown that flavonoids can affect iron status, reduce deposition, inhibit the lipid peroxidation process caused by overload. Therefore, with antioxidant activities may become potential complementary therapies. In this study, we not only reviewed research progress overload regulation mechanism flavonoids, but also studied structural basis their function. addition, advantages disadvantages as plant discussed to provide foundation prevention homeostasis disorders using flavonoids.

Language: Английский

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Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Oct. 18, 2021

Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS). However, IONPs may damage neural tissue via free iron accumulation, protein aggregation, and oxidative stress. Neuroprotective effects of quercetin (QC) proven due its antioxidant anti-inflammatory properties. poor solubility low bioavailability QC also led researchers make various QC-involved overcome these limitations. We wondered how high doses or prolonged treatment with conjugated superparamagnetic (QCSPIONs) could improve cognitive dysfunction promote neurogenesis without any toxicity. It can be explained that inhibits aggregation acts against overload iron-chelating activity, homeostasis genes regulation, radical scavenging, attenuation Fenton/Haber-Weiss reaction. In this review, first, we present brain homeostasis, molecular mechanisms induced neurotoxicity, role dementia-associated diseases. Then by providing evidence discuss neutralizes finally, a brief comparison between conventional chelators. highlight supplementation especially form reduces neurotoxicity clinical application.

Language: Английский

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Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1247 - 1247

Published: Jan. 23, 2022

The antioxidant/pro-oxidant activity of drugs and dietary molecules their role in the maintenance redox homeostasis, as well implications health different diseases, have not yet been fully evaluated. In particular, other interactions with essential metal ions, such iron copper, need further investigation. These ions are ubiquitous human nutrition but also widely found supplements appear to exert major effects on homeostasis health, many diseases free radical pathology. this context, mechanistic insights mainly three prototype groups drugs, namely alpha-ketohydroxypyridines (alpha-hydroxypyridones), e.g., deferiprone, anthraquinones, doxorubicin thiosemicarbazones, triapine complexes were examined; details mechanisms reviewed, emphasis biological potential clinical applications, including anticancer activity. Furthermore, properties these classes chelators compared those chelating vitamin C, an future application prospects cancer, neurodegenerative diseases.

Language: Английский

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Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 3, 2022

Abstract Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid peroxidation. inhibition thought as promising therapeutic strategy for variety diseases. Currently, majority known ferroptosis inhibitors belong to either antioxidants or iron-chelators. Here we report inhibitor, termed YL-939, which neither an antioxidant nor iron-chelator. Chemical proteomics revealed the biological target YL-939 be prohibitin 2 (PHB2). Mechanistically, binding PHB2 promotes expression iron storage protein ferritin, hence reduces content, thereby decreasing susceptibility ferroptosis. We further showed that could substantially ameliorate liver damage in ferroptosis-related acute injury model targeting PHB2/ferritin/iron axis. Overall, identified non-classical inhibitor and regulation mechanism These findings may present attractive intervention

Language: Английский

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