EGFR and JAK2 were significant master gene biomarkers in invasive and noninvasive pituitary adenoma DOI Creative Commons
Afsaneh Ghasemi, Zhila Fereidouni, Fahimeh Maleki‐Sheikhabadi

et al.

Precision Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract The pituitary adenoma (PA) is a common benign tumor of the gland. Pituitary tumors and healthy tissues, as well different types tumors, have distinct metabolite profiles. However, noninvasive to invasive transcriptional alterations, widely assumed be therapeutic targets, not yet been characterized. We describe comprehensive identification differentially expressed genes (DEGs) between controls, using microarray data for 70 samples from Gene Expression Omnibus database, spanning four most frequent subtypes. There were total 940 DEGs unique prolactin 437 nonfunctional 217 shared by all categories. Many relevant biological functions altered, revealed functional enrichment analysis. Involvement in cell cycle, AGE‐RAGE, NF Kappa B, cytokine–cytokine interaction, B‐ T‐cell receptors signaling identified significant pathways high‐expression genes. In contrast, extracellular matrix, RAS signaling, breast cancer‐related pathways, focal adhesion, RAP1 axon guidance, RNA degradation low‐expression Also, EGFR JAK2 had prominent role invasion PA. By performing thorough bioinformatics analysis transcriptomics available PA, we able isolate subset metabolically related that may represent novel highly promising treatment targets.

Language: Английский

Roles of Non-Coding RNA in Alzheimer’s Disease Pathophysiology DOI Open Access
Edward O. Olufunmilayo, R. M. Damian Holsinger

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12498 - 12498

Published: Aug. 6, 2023

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that accompanied by deficits in memory and cognitive functions. The pathologically characterised the accumulation aggregation of an extracellular peptide referred to as amyloid-β (Aβ) form amyloid plaques intracellular hyperphosphorelated protein tau neurofibrillary tangles (NFTs) cause neuroinflammation, synaptic dysfunction, oxidative stress. search for pathomechanisms leading onset progression has identified many key players include genetic, epigenetic, behavioural, environmental factors, which lend support fact this multi-faceted where failure various systems contributes progression. Although vast majority individuals present with sporadic (non-genetic) disease, dysfunctions numerous protein-coding non-coding genes have been implicated mechanisms contributing disease. Recent studies provided strong evidence association RNAs (ncRNAs) AD. In review, we highlight current findings on changes observed circular RNA (circRNA), microRNA (miRNA), short interfering (siRNA), piwi-interacting (piRNA), long (lncRNA) Variations these ncRNAs could potentially serve biomarkers or therapeutic targets diagnosis treatment We also discuss results targeted cellular animal models AD view translating into therapies

Language: Английский

Citations

33
EGFR is a potential dual molecular target for cancer and Alzheimer’s disease DOI Creative Commons
Hee-Jeong Choi,

Yoo Joo Jeong,

Ji‐Eun Kim

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 2, 2023

Many researchers are attempting to identify drugs that can be repurposed as effective therapies for Alzheimer’s disease (AD). Several recent studies have highlighted epidermal growth factor receptor (EGFR) inhibitors approved use anti-cancer potential candidates repurposing AD therapeutics. In cancer, EGFR target cell proliferation and angiogenesis, in mouse models shown attenuate amyloid-beta (Aβ) pathology improve cognitive function. this review, we discuss the different functions of cancer a dual molecular diseases. addition, describe effects tyrosine kinase (TKIs) on their prospects therapeutic interventions AD. By summarizing physiological AD, review emphasizes significance an important these

Language: Английский

Citations

32
Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration DOI
Jinbin Xu,

Huifangjie L. Farsad,

Yiran Hou

et al.

Nature Aging, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 9, 2023

Language: Английский

Citations

24
Nanoparticle Association with Brain Cells Is Augmented by Protein Coronas Formed in Cerebrospinal Fluid DOI
Claire Rennie, Nabila Morshed, Matthew Faria

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Neuronanomedicine harnesses nanoparticle technology for the treatment of neurological disorders. An unavoidable consequence delivery to biological systems is formation a protein corona on surface. Despite well-established influence behavior and fate, as well FDA approval neuro-targeted nanotherapeutics, effect physiologically relevant nanoparticle-brain cell interactions insufficiently explored. Indeed, less than 1% studies have investigated coronas formed in cerebrospinal fluid (CSF), surrounding brain. Herein, we utilize two clinically polymeric nanoparticles (PLGA PLGA-PEG) evaluate serum CSF coronas. LC-MS analysis revealed distinct compositions, with selective enrichment/depletion profiles. Enhanced association precoated particles brain cells demonstrates importance selecting fluids more accurately study subsequent nanoparticle-cell interactions, paving way improved engineering vivo applications.

Language: Английский

Citations

1
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord DOI Open Access
Qi Zhang, Xianming Wu,

Yongheng Fan

et al.

EMBO Reports, Journal Year: 2021, Volume and Issue: 22(11)

Published: Oct. 4, 2021

Language: Английский

Citations

44
Genes and Longevity of Lifespan DOI Open Access
May Bin‐Jumah, Muhammad Shahid Nadeem, Sadaf Jamal Gilani

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1499 - 1499

Published: Jan. 28, 2022

Aging is a complex process indicated by low energy levels, declined physiological activity, stress induced loss of homeostasis leading to the risk diseases and mortality. Recent developments in medical sciences an increased availability nutritional requirements has significantly average human lifespan worldwide. Several environmental factors contribute aging process. However, about 40% life expectancy inherited among generations, many associated genes, genetic mechanisms pathways have been demonstrated during last decades. In present review, we evaluated genes their non-human orthologs established for role regulation lifespan. The study included more than fifty reported literature contributions longevity life. Intact genomic DNA essential activities at level cell, tissue, organ. Nucleic acids are vulnerable oxidative stress, chemotherapies, exposure radiations. Efficient repair maintenance integrity, damaged not replicated transferred next generations rather presence deleterious initiates signaling cascades cell cycle arrest or apoptosis. modifications, methylation, histone acetylation damage can eventually lead towards importance calorie restriction therapy extension also discussed. involved such as DAF-16/FOXO (forkhead box protein O1), TOR JNK particularized. provides updated account with extended interactive contributory cellular pathways.

Language: Английский

Citations

36
Implicative role of epidermal growth factor receptor and its associated signaling partners in the pathogenesis of Alzheimer’s disease DOI
Pavan K. Jayaswamy,

M. Vijaykrishnaraj,

Prakash Patil

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 83, P. 101791 - 101791

Published: Nov. 17, 2022

Language: Английский

Citations

33
Control of cell metabolism by the epidermal growth factor receptor DOI Creative Commons
Laura A. Orofiamma,

Dafne Vural,

Costin N. Antonescu

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2022, Volume and Issue: 1869(12), P. 119359 - 119359

Published: Sept. 9, 2022

Language: Английский

Citations

31
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis DOI Creative Commons

Vipavee Niemsiri,

Sara Brin Rosenthal, Caroline M. Nievergelt

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(1), P. 6 - 19

Published: March 29, 2023

Abstract Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there presently no way to predict response guide treatment. The aim this study identify functional genes and pathways that distinguish BD Li responders (LR) from non-responders (NR). An initial Pharmacogenomics Bipolar Disorder (PGBD) GWAS lithium did not provide any significant results. As a result, we then employed network-based integrative analysis transcriptomic genomic data. In iPSC-derived neurons, 41 significantly differentially expressed (DE) were identified in LR vs NR regardless exposure. PGBD, post-GWAS gene prioritization using GWA-boosting (GWAB) approach 1119 candidate genes. Following DE-derived network propagation, was highly overlap between top 500- 2000-proximal networks GWAB list ( P hypergeometric = 1.28E–09 4.10E–18, respectively). Functional enrichment analyses 500 proximal focal adhesion extracellular matrix (ECM) as functions. Our findings suggest difference much greater effect than lithium. direct impact dysregulation on axon guidance neuronal circuits could underpin mechanisms lithium, well underlying BD. It also highlights power multi-omics profiling gain molecular insights into

Language: Английский

Citations

21
Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists DOI Creative Commons

Lukša Popović,

Jan P. Wintgens, Yuxin Wu

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(2), P. 108839 - 108839

Published: Jan. 9, 2024

ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, mental disorders. Although existing drugs target receptors, the next generation of requires enhanced selectivity understanding physiological pathway responses to improve efficiency reduce side effects. To address this, we developed a multilevel barcoded reporter profiling assay, termed 'ERBBprofiler', living cells monitor activity all targets key pathways simultaneously. This assay helps differentiate on-target therapeutic effects from off-target off-pathway antagonists. challenge eight established antagonists were profiled. Known confirmed, previously uncharacterized properties discovered, such as pyrotinib's preference for ERBB4 over EGFR. Additionally, two lead compounds selectively targeting profiled, showing promise clinical trials. Taken together, this multiparametric approach can guide early-stage drug improved future interventions.

Language: Английский

Citations

7