Toxicology International,
Journal Year:
2024,
Volume and Issue:
unknown, P. 593 - 606
Published: Sept. 13, 2024
The
life
span
of
organisms
becomes
very
flexible
and
vulnerable
due
to
environmental
climatic
changes,
which
have
both
natural
man-made
factors.
One
such
example
is
the
inappropriate
use
insecticides
pesticides
in
agriculture
health
sectors,
cause
pollution,
despite
their
agricultural
benefits.
Two
most
widely
used
organophosphate
insecticides,
chlorpyrifos
(CP)
ethion
(ET),
are
known
neurotoxic
properties
they
target
inhibit
neurotransmitter
function
acetylcholinesterase
(AChE)
insects.
Previous
studies
shown
that
exposure
these
brings
detrimental
effects
non-targets
including
humans.
present
work
aims
estimate
CP
ET
on
lifespan
two
sibling
species
Drosophila,
Drosophila
melanogaster
simulans,
after
being
exposed
for
24
48
hrs
sublethal
concentrations
(determined
from
LC₅₀
LC₉₀).
To
understand
molecular
mechanism
behind
this,
Differential
Expression
Gene
(DEG)
analysis
ET-exposed
flies
was
carried
out
through
whole
transcriptome
sequencing,
shows
85
upregulated
95
downregulated
ageing-associated
genes,
involved
regulation
cell
cycle,
growth
development.
were
then
continuously
cultured
insecticide-treated
untreated
media
(Control)
ten
generations,
calculated
(Control
vs
F₁
vs.
F₁₀).
In
comparison,
results
revealed
a
remarkable
reduction
treated,
increased
F₁₀
treated
flies,
but
still,
it
did
not
reach
up
average
control.
Thus,
long-term
effect
insecticide
cannot
be
overlooked
needs
further
addressed.
npj Aging,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: July 10, 2024
Abstract
The
ability
to
reprogram
patient-derived-somatic
cells
IPSCs
(Induced
Pluripotent
Stem
Cells)
has
led
a
better
understanding
of
aging
and
age-related
diseases
like
Parkinson’s,
Alzheimer’s.
established
patient-derived
disease
models
mimic
pathology
can
be
used
design
drugs
for
diseases.
However,
the
age
genetic
mutations
donor
cells,
employed
reprogramming,
differentiation
protocol
might
often
pose
challenges
in
establishing
an
appropriate
model.
In
this
review,
we
will
focus
on
various
strategies
successful
reprogramming
diseases,
emphasizing
accuracy
recapitulation
ways
overcome
limitations
its
potential
application
cell
replacement
therapy
drug
development.
Journal of Translational Autoimmunity,
Journal Year:
2024,
Volume and Issue:
8, P. 100237 - 100237
Published: March 2, 2024
Autoimmune
diseases
(ADs)
are
one
of
the
groups
chronic
illnesses
that
impose
a
significant
burden
disease
and
health
costs
worldwide.
Age
is
crucial
risk
factor
for
onset
ADs.
Theoretically,
it
inferred
with
organic
immune
system
aging,
loss
tolerance
specificity
activity
becomes
more
intense,
probability
autoimmunity
increasing.
However,
there
group
individuals
whose
prevalence
ADs
very
low
or
non-existent,
despite
biological
aging.
This
paradox
in
raises
questions.
Centenarians,
who
over
100
years
old,
possibly
most
successful
model
aging
humans.
Most
these
exhibit
favorable
phenotype.
To
date,
primary
data
evidence
potential
hypotheses
explaining
this
phenomenon
lacking
globally,
even
though
could
provide
valuable,
original,
relevant
information
regarding
understanding
protective
factors,
drivers,
biomarkers
related
to
autoimmunity.
Herein
we
discuss
some
hypothesis
may
explain
absence
centenarians,
including
inflammaging,
immunosenescence
resilience,
hyperstimulation,
proteodynamics,
genetics.
Bioagro,
Journal Year:
2025,
Volume and Issue:
37(1), P. 13 - 24
Published: Jan. 1, 2025
Pyriproxyfen,
a
juvenile
hormone
analog
(JHA),
is
considered
as
reduced-risk
alternative
to
synthetic
pesticides
for
crop
protection.
It
has
been
frequently
used
in
agriculture
and
public
health
manage
insect
pests.
However,
recent
studies
have
reported
that
pyriproxyfen
may
adverse
physiological
effects
on
non-target
organisms.
This
study
investigated
the
of
sublethal
doses
endocrine
disrupting
insecticide
Drosophila
melanogaster
Meigen
(Diptera:
Drosophilidae)
biological
model.
Results
showed
had
noticeable
effect
developmental
stages
individuals
exposed
generation.
Pyriproxyfen
treatment
significantly
shortens
adult
longevity
both
sexes,
female
male.
Finally,
these
results
suggest
reproduction
capacity
D.
impacted
by
reducing
number
progeny
after
parent’s
generation
with
pyriproxyfen.
These
research
findings
indicate
exposure
induces
affects
offspring
growth
rates
insects
Drosophila.
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 15, 2025
Understanding
the
determinants
of
life
expectancy
(LE)
is
essential
for
effective
policy
planning
and
enhancing
public
health
in
Gulf
Cooperation
Council
(GCC)
countries.
This
study
aims
to
elucidate
complex
interactions
among
sociodemographic
(SD),
macroeconomic
(ME),
resource
(HR)
factors
that
influence
LE
GCC
We
employed
a
Meta-Analytic
Structural
Equation
Modeling
develop
comparative
model
across
six
countries
using
annual
data
from
1990
2020.
The
pairwise
comparison
utilized
Partial
Least
Squares
Multi-Group
Analysis,
allowing
us
examine
differences
SD,
ME,
HR
influences
on
Our
analysis
highlighted
ME
directly
impact
all
examined.
observed
significant
mediation
effects
where
SD
influenced
or
HR,
affecting
LE.
Notably,
final
comparisons
revealed
was
particularly
significant,
with
effect
sizes
ranging
0.2679
(p
=
0.0018)
Oman-Kuwait
0.6686
<
0.0001)
Emirate-Saudi
comparison.
Furthermore,
while
consistently
each
model,
their
impacts
did
not
show
variations
between
pairing.
Generally,
findings
highlight
critical
need
strengthen
integrated
framework
rather
than
relying
solely
improvements.
Specifically,
importance
tailoring
policies
address
specific
contexts
within
enhance
effectively.
insights
gained
our
could
significantly
inform
targeted
initiatives
provide
valuable
reference
future
research
similar
settings.
Trends in Cell Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
HighlightsSystems-level
approaches
complement
static
insights
by
revealing
how
gene
regulatory
networks
(GRNs)
dynamically
regulate
cellular
aging
and
promote
longevity.Observing
the
dynamics
of
heme
biosynthesis
nucleolar
silencing
in
budding
yeast
reveals
distinct
modes,
synthetic
biology
can
significantly
extend
lifespan.Negative
feedback
loops
aging-related
processes
such
as
proteostasis,
energy
metabolism,
DNA
damage
response
pathways
maintain
homeostasis
counteract
deterioration.Synthetic
offers
potential
interventions
to
reinforce
circuits,
thereby
mitigating
age-related
diseases
promoting
healthy
aging.AbstractAging
is
a
dynamic
process
that
driven
disruption
homeostatic
(GRNs).
Traditional
studies
often
focus
on
individual
genes,
but
understanding
their
interplay
key
unraveling
mechanisms
aging.
This
review
explores
circuits
influence
longevity
highlights
role
maintaining
balance.
The
SIR2–HAP
circuit
serves
model
explore
mutual
inhibition
between
influences
trajectories
engineering
stable
fixed
points
or
oscillations
within
these
lifespan.
Feedback
crucial
for
are
also
reviewed,
we
highlight
destabilization
accelerates
By
leveraging
systems
biology,
strategies
proposed
may
stabilize
single
cells,
enhancing
resilience
damage.
Geriatrics,
Journal Year:
2024,
Volume and Issue:
9(4), P. 93 - 93
Published: July 12, 2024
Studying
aging
now
requires
going
beyond
the
bio-psycho-social
model
and
incorporating
a
broader
multidisciplinary
view
capable
of
capturing
ultimate
complexity
being
human
that
is
expressed
as
individuals
age.
Current
demographic
trends
lengthening
life
expectancies
allow
observation
long-lived
in
full
health.
These
super-agers
are
no
longer
an
exception.
Indeed,
can
have
good
quality
even
over
age
70
living
with
chronic
or
neurodegenerative
diseases.
This
change
driven
part
by
cohort
effect
observed
people
who
about
to
today
(e.g.,
better
schooling,
more
advanced
health
conditions,
technologization)
but
so
gradual
overcoming
ageist
views.
An
aged
person
seen
quitter
rather
one
empowered
direct
their
own
trajectory
potentially
healthy
longevity.
According
this
vision,
article
proposes
situated
lifespan
perspective
for
study
integrates
pedagogical
models
developmental
ecology
psychological
theories
optimal
experience
understand
individual
motivational
on
aging.
At
same
time,
it
does
not
disregard
analyzing
daily
cultural
contexts
which
everyone
situates
guide
trajectories.
Nor
forget
body-mind
(embodied)
organisms
that,
through
motivations,
seize
opportunities
action
(affordances)
evolve
way
during
lifespan.
theoretical
reflection
sheds
new
light
process
future
longevity
research.
