International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(16), P. 9272 - 9272
Published: Aug. 17, 2022
This
review
is
devoted
to
changes
in
the
post-transcriptional
maturation
of
RNA
human
glioblastoma
cells,
which
leads
disruption
normal
course
apoptosis
them.
The
thoroughly
highlights
latest
information
on
both
modifications
certain
regulatory
RNAs,
associated
with
process
apoptosis,
presents
data
features
and
shows
relationship
between
RNAs
tumor
cells.
In
conclusion,
potential
target
candidates
are
presented
that
necessary
for
development
new
drugs
treatment
glioblastoma.
Journal of Oncology,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 16
Published: Sept. 21, 2022
Glioblastoma
multiforme
is
a
serious
and
life-threatening
tumor
of
central
nervous
system,
characterized
by
aggressive
behavior,
poor
prognosis,
low
survival
rate.
Despite
the
availability
antitumor
therapeutic
regimen
for
glioblastoma
(radiotherapy
followed
chemotherapeutic
dose),
recovery
rate,
patients'
ratio
attributed
to
lack
selectivity
drugs
less
advancement
in
cancer
therapeutics
over
last
decade.
Moreover,
tools
employed
conventional
diagnosis
are
more
invasive
painful,
making
process
excruciating
patients.
These
challenges
urge
need
novel
biomarkers
diagnosis,
prediction
purpose
with
invasiveness
patient
compliance.
This
article
will
explore
genetic
isocitrate
dehydrogenase
mutation,
MGMT
mutations,
EGFR
that
can
be
deployed
as
an
analytical
tool
disease
prognosis
course.
The
review
also
highlights
importance
employing
microRNAs
prognostic
biomarkers.
Recent
clinical
advancements
treat
GBM
prevent
relapse
discussed
this
hope
finding
robust
effective
method
GBM.
Bioengineered,
Journal Year:
2022,
Volume and Issue:
13(6), P. 14125 - 14137
Published: June 1, 2022
Temozolomide
(TMZ)
is
the
primary
chemotherapeutic
drug
for
treating
glioblastoma
(GBM);
however,
final
clinical
outcome
considerably
limited
by
poor
response
and
resistance
to
TMZ.
Although
autophagy
thought
be
associated
with
chemotherapy
cancer
cell
survival,
precise
molecular
mechanisms
underlying
this
process
remain
elusive.
The
suppressor
of
cytokine
signaling
(SOCS)
family
widely
distributed
in
vivo
exerts
a
range
effects
on
tumors;
expression
pattern
role
SOCS
GBM
remains
unknown.
In
study,
we
determined
that
high
SOCS5
level
was
prognosis
TMZ
GBM.
induced
an
increase
upregulated
during
acquisition
resistance.
observed
extent
mediated
SOCS5.
Mechanistically,
enhances
transcription
Bcl-2.
Knockdown
inhibited
chemoresistance
cells
through
inhibition
Bcl-2
recruited
autophagy;
upregulation
blocked
effect.
summary,
our
findings
revealed
involvement
mechanism
plays
critical
may
serve
as
novel
prognostic
marker
therapeutic
target
chemotherapeutically
drug-resistant
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(16), P. 9272 - 9272
Published: Aug. 17, 2022
This
review
is
devoted
to
changes
in
the
post-transcriptional
maturation
of
RNA
human
glioblastoma
cells,
which
leads
disruption
normal
course
apoptosis
them.
The
thoroughly
highlights
latest
information
on
both
modifications
certain
regulatory
RNAs,
associated
with
process
apoptosis,
presents
data
features
and
shows
relationship
between
RNAs
tumor
cells.
In
conclusion,
potential
target
candidates
are
presented
that
necessary
for
development
new
drugs
treatment
glioblastoma.
