New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(32), P. 14170 - 14174
Published: Jan. 1, 2024
The inherent superhydrophobicity of a plant's leaves results in low deposition efficiency pesticides used to improve crop production.
Language: Английский
Advanced Sensor Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Abstract Surface‐enhanced Raman spectroscopy (SERS) has emerged as a powerful tool for biomedical diagnosis, combining heightened sensitivity with molecular precision. The integration of artificial intelligence (AI) and machine learning (ML) further elevated its capabilities, refining data interpretation, pattern prediction, bolstering diagnostic accuracy. This review chronicles advancements in SERS diagnostics, emphasizing the collaboration between ML innovative nanostructures, substrates, nanoprobes enhancement. breakthroughs are highlighted SERS‐based point‐of‐care techniques nuanced detection key biomarkers, from nucleic acids to proteins metabolites. article also addresses prevailing challenges, such need standardized methodologies optimized platforms. Moreover, potential portable systems is discussed clinical deployment, well current efforts challenges trials. In essence, this positions fusion nanoengineering, AI, ML, frontier next‐generation diagnostics.
Language: Английский
Citations
3
Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5360 - 5360
Published: July 12, 2023
Near-infrared (NIR) fluorescence is a noninvasive, highly sensitive, and high-resolution modality with great potential for in vivo imaging. Compared “Always-On” probes, activatable NIR fluorescent probes “Turn-Off/On” or “Ratiometric” signals at target sites exhibit better signal-to-noise ratio (SNR), wherein enzymes are one of the ideal triggers probe activation, which play vital roles variety biological processes. In this review, we provide an overview enzyme-activatable concentrate on design strategies sensing mechanisms. We focus aggregation/dispersion state fluorophores after interaction finally discuss current challenges some perspective ideas construction probes.
Language: Английский
Citations
7
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215588 - 215588
Published: Nov. 29, 2023
Language: Английский
Citations
7
Nanoscale, Journal Year: 2024, Volume and Issue: 16(25), P. 11879 - 11913
Published: Jan. 1, 2024
Brain disorders, including neurodegenerative diseases (NDs) and traumatic brain injury (TBI), present significant challenges in early diagnosis intervention. Conventional imaging modalities, while valuable, lack the molecular specificity necessary for precise disease characterization. Compared to study of conventional tissues, liquid biopsy, which focuses on blood, tear, saliva, cerebrospinal fluid (CSF), also unveils a myriad underlying processes, providing abundant predictive clinical information. In addition, biopsy is minimally- non-invasive, highly repeatable, offering potential continuous monitoring. Raman spectroscopy (RS), with its ability provide rich information cost-effectiveness, holds great transformative advancements detection understanding biochemical changes associated NDs TBI. Recent developments enhancement technologies advanced data analysis methods have enhanced applicability RS probing intricate signatures within biological fluids, new insights into pathology. This review explores growing role as promising emerging tool particularly through biopsy. It discusses current landscape future prospects highlighting non-invasive molecularly specific diagnostic tool.
Language: Английский
Citations
2
Dalton Transactions, Journal Year: 2023, Volume and Issue: 53(8), P. 3434 - 3444
Published: Dec. 29, 2023
Bacterial infections can lead to the development of large-scale outbreaks diseases that pose a serious threat human life and health. Also, conventional antibiotics are prone producing resistance allergic reactions, their therapeutic effect is dramatically diminished when bacterial communities form biofilms. Fortunately, well-designed supramolecular coordination complexes (SCCs) have been used as antibacterials or anti-biofilms in recent years. SCCs kill bacteria by directly engaging with surface through electrostatic interactions penetrating membrane auxiliary cell-penetrating peptides. Furthermore, scientists engineered fluorescent produce reactive oxygen species (ROS) eliminate exposed laser irradiation, they also demonstrate outstanding performance
Language: Английский
Citations
4
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 663, P. 295 - 308
Published: Feb. 15, 2024
Language: Английский
Citations
1
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1839 - 1839
Published: Nov. 17, 2024
Surface-enhanced Raman scattering (SERS) is an innovative spectroscopic technique that amplifies the signals of molecules adsorbed on rough metal surfaces, making it pivotal for single-molecule detection in complex biological and environmental matrices. This review aims to elucidate design strategies recent advancements application standalone SERS nanoprobes, with a special focus quantifiable tags. We conducted comprehensive analysis literature, focusing development nanoprobes employ novel nanostructuring techniques enhance signal reliability quantification. Standalone exhibit significant enhancements sensitivity specificity due optimized hot spot generation improved reporter molecule interactions. Recent innovations include nanogap core-satellite structures electromagnetic fields, which are crucial applications. particularly those utilizing indirect mechanisms, represent advancement field. They hold potential wide-ranging applications, from disease diagnostics monitoring, owing their enhanced ability operate under sample conditions.
Language: Английский
Citations
1
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(5), P. 1274 - 1280
Published: Jan. 1, 2024
Herein, we show a pair of leucine-rich L- and D-phosphopeptides which self-assemble into twisting nanofibers, whose secondary structures contain strong β-sheet component after being dephosphorylated by alkaline phosphatase (ALP). While incubated with ALP overexpressing osteosarcoma cells, both the peptides in nuclei induce cell death. The death involves multiple modalities occurs along disruption membranes. Enzyme-instructed self-assembly (EISA) inhibits cells shows no side effect to other cells. In addition, cancer hardly gain drug resistance repeated treatment. This work reports EISA-based nanofibers target nuclei, also provides novel chemotherapeutic agent inhibit without effects resistance.
Language: Английский
Citations
0
New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(32), P. 14170 - 14174
Published: Jan. 1, 2024
The inherent superhydrophobicity of a plant's leaves results in low deposition efficiency pesticides used to improve crop production.
Language: Английский
Citations
0