Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(07), P. 11475 - 11483
Published: Jan. 1, 2023
Language: Английский
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Age-related macular degeneration (AMD) is a prevalent degenerative disorder of the central retina, which holds global significance as fourth leading cause blindness. The condition characterized by multifaceted pathophysiology that involves aging, oxidative stress, inflammation, vascular dysfunction, and complement activation. complex interplay these factors contributes to initiation progression AMD. Current treatments primarily address choroidal neovascularization (CNV) in neovascular However, approval novel drug therapies for atrophic more gradual variant, known geographic atrophy (GA), has recently occurred. In light substantial impact AMD on affected individuals' quality life strain it places healthcare systems, there pressing need innovative medications. This paper aims provide an updated comprehensive overview advancements our understanding etiopathogenesis Special attention will be given influence aging altered redox status mitochondrial dynamics, cell death pathways, intricate between stress system, specifically context GA. Additionally, this review shed newly approved explore emerging alternative treatment strategies field. objective contribute ongoing dialogue surrounding AMD, offering insights into latest developments may pave way effective management intervention approaches.
Language: Английский
Citations
12
Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1060 - 1060
Published: Aug. 30, 2024
Carotenoids, known for their antioxidant properties, have garnered significant attention potential antitumour activities. This comprehensive review aims to elucidate the diverse mechanisms by which carotenoids exert effects, focusing on both well-established and novel findings. We explore role in inducing apoptosis, inhibiting cell cycle progression preventing metastasis affecting oncogenic tumour suppressor proteins. The also explores pro-oxidant function of within cancer cells. In fact, although overall contribution cellular defences is well significant, some can exhibit effects under certain conditions are able elevate reactive oxygen species (ROS) levels tumoural cells, triggering mitochondrial pathways that would lead death. final balance between activities depends several factors, including specific carotenoid, its concentration redox environment cell. Clinical trials discussed, highlighting conflicting results treatment importance personalized approaches. Emerging research rare like bacterioruberin showcases superior capacity selective cytotoxicity against aggressive subtypes, such as triple-negative breast cancer. Future directions include innovative delivery systems, combinations treatments, aiming enhance therapeutic carotenoids. highlights promising yet complex landscape carotenoid-based therapies, calling continued clinical exploration.
Language: Английский
Citations
9
Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1114 - 1114
Published: Sept. 14, 2024
Aging and age-related diseases are serious public health issues that receiving growing attention from researchers. Lutein has a critical function in the prevention management of these issues. Possible mechanisms mainly include suppressing inflammation oxidative stress, regulating cell activity, modulating levels toxic substances. In this narrative review paper, we sum up most current developments study effects lutein on aging five (age-related macular degeneration, cataracts, Alzheimer’s disease, Parkinson’s osteoporosis), fundamental reviewed. The bioavailability strategies to improve its discussed. This piece work can bring clearer comprehension protective against be also helpful for developing as functional food dietary supplements diseases.
Language: Английский
Citations
6
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156578 - 156578
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101285 - 101285
Published: March 1, 2025
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
The aim of this study was to determine whether oxidative stress-induced premature senescence in mouse auditory cell line HEI-OC1 cells vitro is associated with NLRP3 inflammasome activation and pyroptosis, melatonin has a protective effect. were exposed different concentrations hydrogen peroxide (H2O2) induce stress subsequently analyzed by Western blotting measure pyroptosis-related proteins - NLRP3, caspase-1, GSDMD-N. Compared untreated control cells, exposure promoted accompanied significant increase levels Furthermore, treatment shown decrease the expression these attenuate H2O2-induced process. contributes vitro, leading pyroptosis. Melatonin attenuates pyroptosis inhibiting GSDMD-N, providing reliable evidence for as potential therapeutic agent age-related hearing loss.
Language: Английский
Citations
0
Cell Biochemistry and Function, Journal Year: 2023, Volume and Issue: 41(8), P. 1162 - 1173
Published: Sept. 10, 2023
This study investigated the role of phospholipase D (PLD) in retinal ischemia-reperfusion (I/R) injury using an oxygen-glucose deprivation/reperfusion (OGD/R) model commonly used I/R research. To create vitro cellular model, pharmacological inhibitors and small interfering RNA (siRNA) were to target PLD1 PLD2 pigment epithelial (RPE) cells. Treatment with PLD siRNA reduced reactive oxygen species (ROS) malondialdehyde (MDA) induced by OGD/R RPE cells increased levels superoxide dismutase (SOD) glutathione (GSH), indicating a reduction oxidative damage improvement antioxidant system. Next, we showed that inhibiting or intracellular iron lipid peroxidation, which are critical factors ferroptosis. Additionally, modulated expression proteins involved regulation ferroptosis, including GPX4, SLC7A11, FTH1, ACSL4. We also roles preventing pyroptosis, another form programmed cell death associated inflammation. Our found significantly production pro-inflammatory cytokines activated caspase-1, NLRP3, ASC, cleaved-caspase 1 (C-caspase-1), GSDMD-N cells, pyroptosis induction. However, inhibition knockdown inhibited activation NLRP3 inflammasome, Taken together, our findings support hypothesis signaling pathway plays key OGD/R-induced ferroptosis induction may be potential therapeutic for treating dysfunction degeneration.
Language: Английский
Citations
5
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(1), P. 295 - 295
Published: Jan. 4, 2024
Age-related macular degeneration (AMD) is the leading cause of vision loss in people over 60 years age. Despite research, causes AMD remain unclear. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are known to be involved development, anti-vascular endothelial growth factor therapy has revolutionized its treatment. This study aims analyze changes gene expression MMPs TIMPS patients with neovascular before after three doses ranibizumab. The 29 treated Peripheral blood mononuclear cells were collected treatment 24 h third dose We assessed MMP TIMP profiles through oligonucleotide microarrays validated selected differential genes using RT-qPCR. A statistically significant change six MMP- TIMP-related was observed microarray. mRNA levels two most fold changes, MMP15 TIMP2, then quantified results confirmed a increase decrease TIMP2 levels, although this not group Ranibizumab affects systemic AMD. Results from our exploratory suggest that MMP15, particular, may play role response, but further research necessary.
Language: Английский
Citations
1
Inflammation, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 31, 2024
Language: Английский
Citations
1
Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(07), P. 11475 - 11483
Published: Jan. 1, 2023
Language: Английский
Citations
0