Experimental Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 110110 - 110110
Published: Sept. 1, 2024
Language: Английский
GeroScience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
3
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 594 - 594
Published: May 12, 2024
Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus, characterized by irreversible visual impairment resulting from microvascular abnormalities. Since the global prevalence continues to escalate, DR has emerged as prominent area research interest. The development and progression encompass complex interplay pathological physiological mechanisms, such high glucose-induced oxidative stress, immune responses, vascular endothelial dysfunction, well damage retinal neurons. Recent years have unveiled involvement genomic epigenetic factors in formation mechanisms. At present, extensive explores potential biomarkers cytokines, molecular cell therapies, antioxidant interventions, gene therapy for treatment. Notably, certain drugs, anti-VEGF agents, antioxidants, inhibitors inflammatory protein kinase C (PKC)-β inhibitors, demonstrated promising outcomes clinical trials. Within this context, review article aims introduce recent on highlight current progress field, with particular focus emerging experimental treatment strategies targeting redox signaling pathways.
Language: Английский
Citations
13
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
1
Medicina, Journal Year: 2024, Volume and Issue: 60(6), P. 945 - 945
Published: June 5, 2024
The complement cascade is a vital system in the human body’s defense against pathogens. During natural aging process, it has been observed that this imperative for ensuring integrity and homeostasis of retina. While critical proper host retinal integrity, also found dysregulation may lead to certain pathologies, including geographic atrophy diabetic retinopathy. Targeting components diseases an area interest, vivo, ex clinical trials have conducted area. Following trials, medications targeting disease become available. In manuscript, we discuss pathophysiology dysfunction retina specific pathologies. We then describe results cellular, animal, studies diseases. provide overview inhibitors approved by Food Drug Administration (FDA) atrophy. continues serve as emerging therapeutic target, further research field will additional insights into mechanisms considerations treatment
Language: Английский
Citations
5
Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(12), P. 20 - 20
Published: Oct. 15, 2024
Age-related macular degeneration (AMD) stands as a leading cause of severe visual impairment and blindness among the elderly globally. As multifactorial disease, AMD's pathogenesis is influenced by genetic, environmental, age-related factors, with lipid metabolism abnormalities complement system dysregulation playing critical roles. This review delves into recent advancements in understanding intricate interaction between these two crucial pathways, highlighting their contribution to disease's progression through chronic inflammation, drusen formation, retinal pigment epithelium dysfunction. Importantly, emerging evidence points dysregulated profiles, particularly alterations high-density lipoprotein levels, oxidized deposits, intracellular lipofuscin accumulation, exacerbating factors that enhance activation subsequently amplify tissue damage AMD. Furthermore, genetic studies have revealed significant associations AMD specific genes involved transport regulation, shedding light on disease susceptibility underlying mechanisms. The further explores clinical implications findings, advocating for novel therapeutic approach integrates modulators inhibitors. By concurrently targeting dual-targeted holds promise significantly improving outcomes patients, heralding new horizon management treatment.
Language: Английский
Citations
4
Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 4707 - 4728
Published: May 25, 2024
Aging is accompanied by an increased prevalence of degenerative conditions, including those affecting ocular health, which significantly impact quality life and increase the burden on healthcare systems. Among these, retinal aging particular concern due to its direct link vision impairment, a leading cause disability in elderly. Vision loss population associated with heightened risks cognitive decline, social isolation, morbidity. This study addresses critical gap our understanding modifiable lifestyle factors, such as physical exercise, that may mitigate related pathologies. We investigated effects different exercise regimens-voluntary (recreational-type) forced (high-intensity)-on health Wistar rats (18-month-old), serving model for studying translational potential interventions humans. Male were divided into four groups: young control (3-month-old) baseline comparison, aged sedentary control, group engaging voluntary via running wheel their cage, subjected treadmill six sessions 20 min each per week. After 6-month experimental period, we assessed function electroretinography (ERG), measured thickness histologically, analyzed protein expression changes relevant oxidative stress, inflammation, anti-aging mechanisms. Our findings reveal positively impacts morphology, reducing stress inflammation markers while enhancing expression. In contrast, showed diminished benefits. These insights underscore importance intensity preference preserving during aging. The highlights recreational activity non-invasive strategy counteract aging, advocating further research regimens preventative therapies age-related degenerations.
Language: Английский
Citations
3
Life Sciences, Journal Year: 2024, Volume and Issue: 359, P. 123203 - 123203
Published: Nov. 1, 2024
Language: Английский
Citations
3
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1249 - 1249
Published: Oct. 16, 2024
Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-induced damage lens epithelial cells (LECs). Key factors contributing cataract formation include aging, arterial hypertension, and diabetes mellitus. Given the high global prevalence cataracts, burden cataract-related visual impairment is substantial, highlighting need for pharmacological strategies supplement surgical interventions. Understanding molecular pathways involved in stress during development may offer valuable insights designing novel therapeutic approaches. This review explores role formation, focusing on critical mechanisms, such as mitochondrial dysfunction, endoplasmic reticulum stress, loss gap junctions, various cell death LECs. Additionally, we discuss emerging potential targeting options, including antioxidant-based treatments.
Language: Английский
Citations
2
Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 817 - 817
Published: April 8, 2024
Acknowledged as a significant pathogenetic driver for numerous diseases, aging has become focal point in addressing the profound changes associated with increasing human life expectancy, posing critical concern global public health. Emerging evidence suggests that factors influencing vascular extend their impact to choroidal and retinal blood vessels. The objective of this work is provide comprehensive overview on ocular vessels related diseases. Additionally, study aims illuminate molecular insights contributing cell aging, particular emphasis choroid retina. Moreover, innovative targets operating within domain are presented discussed.
Language: Английский
Citations
1