Microplastic and the Enteric Nervous System: Effect of PET Microparticles on Selected Neurotransmitters and Cytokines in the Porcine Ileum DOI Open Access
Ismena Gałęcka, Jarosław Całka

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11645 - 11645

Published: Oct. 30, 2024

Microplastic is an environmental hazard to which both animals and humans are exposed. Current reports show that it can cause inflammation, including in the gastrointestinal tract. To examine impact on ileum, 15 eight-week-old gilts (five individuals/group) were exposed PET microplastics (7.6 µm-416.9 µm) at a dose of 0.1 g/day or 1 for 28 days. The collected ileum fragments investigated cytokine concentrations (IL-1β, IL-6, IL-8, IL-10, TNF-α; ELISA test), neuron populations (cocaine amphetamine-regulated transcript, galanin, neuronal nitric oxide synthase, substance P, vesicular acetylcholine transporter, vasoactive intestinal peptide; immunofluorescence staining), morphometric parameters (histological analysis). Under influence MP-PET, there was reduction CART- GAL-positive neurons submucosal plexuses nNOS-, VAChT-, VIP-positive all plexuses. In contrast, increase myenteric plexus SP-positive IL-1β, TNF-α did not undergo statistically significant changes under low high MP-PET. histological structure exclusively concerned thinning mucosa muscularis externa. results support thesis MP-PET neutral ileal cells.

Language: Английский

The Role of Human Intestinal Mucus in the Prevention of Microplastic Uptake and Cell Damage DOI Creative Commons
Ellen van Wijngaarden, Sandra L. Arias, Matthew W. Rhee

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

An increase in plastic waste and its release into the environment has led to health concerns over microplastics (MPs) environment. The intestinal mucosal layer is a key defense mechanism against ingested MPs, preventing migration of particles other parts body. MP through mucus challenging study due difficulties obtaining intact layers for testing numerous formulations, shapes, sizes microplastics. Previous studies have primarily used from animals, hydrogel models, samples body as substitutes. This examines how different compositions, (40-500 nm), surface functionalizations alter human mucus; protects cells uptake, toxicity, inflammation; prevents environmental toxins via particles. presence also provides critical protection cytotoxicity, reactive oxygen species production, uptake all tested, although certain functionalizations, such streptavidin, are particularly harmful with high toxicity inflammation. Understanding properties that assist impede diffusion MPs relevant overall bioaccumulation effects well drug delivery purposes.

Language: Английский

Citations

2
The association between micro- and nano-plastics and cardiovascular outcomes: a comprehensive review DOI

Soroush Oraee,

Mohammadreza Alinejadfard,

Sajjad Mahdavi

et al.

Toxicology and Environmental Health Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

0
The Infiltration of Microplastics in Human Systems: Gastrointestinal Accumulation and Pathogenic Impacts DOI Creative Commons

Purendra P. Sinha,

Vaishali Saini, Nidhi Varshney

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42606 - e42606

Published: Feb. 1, 2025

Microplastic particles have become ubiquitous in various ecosystems due to a drastic increase plastic use and its consequent litter. The biological effects of these on aquatic fauna are well-documented. However, the study their accumulation subsequent impact terrestrial flora is initial stages. Furthermore, favorable surface provided by plastics lodges harmful substances pathogens known cause varied human physiology. Notably, entry into gastrointestinal tract can result ailments, including dysbiosis gut microflora microbial biodiversity. Moreover, similar physiological ailments been observed humans action pathogenic microorganisms. Therefore, this review, we aim explore relationship possible amplification pathogenesis ability provide surfaces for absorption biofilm formation such Additionally, there exists possibility carcinogenesis coexistence microbes micro-and nanoplastics synergistic leading severe ailments.

Language: Английский

Citations

0
Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics DOI Creative Commons

Jinhua Chi,

Jeffrey Patterson, Yan Jin

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 446 - 446

Published: Feb. 12, 2025

Background: Microplastics (MPs) are small plastic fragments with diameters less than 5 mm in size and prevalent everyday essentials consumables. Large global production has now led to a flooding of MPs our natural environment. Due their detrimental impacts on the planet's ecosystems potentially health, have emerged as significant public health concern. In this pilot study, we hypothesize that exposure will negatively affect gut microbiota composition function, which metabolic reprogramming plays an important role. Methods: Using vitro experiments, three bacterial strains (Escherichia coli MG1655, Nissle 1917, Lactobacillus rhamnosus) were selected investigate exposure. The individually cultured anaerobic chamber exposed 1 µm polystyrene at various concentrations (0, 10, 20, 50, 100, 500 µg/mL) culture medium. Results: reduced growth all dose-dependent manner. Liquid chromatography mass spectrometry (LC-MS)-based untargeted metabolomics revealed differences multiple pathways, such sulfur metabolism amino sugar nucleotide metabolism. addition, extracted from C57BL/6 mice, 16S rRNA sequencing results showed upregulation Lactobacillales reduction Erysipelotrichales due Furthermore, targeted corroborated alterations microbial tryptophan energy producing glycolysis/gluconeogenesis pentose phosphate pathway. Conclusions: These findings provide evidence causes comprehensive changes healthy microbiota, may also insights into mechanistic effects humans.

Language: Английский

Citations

0
Microplastics Accumulation in Fibrotic Intestinal Tissue of Crohn's Disease Patients DOI
Fengfei Wu, Fangting Wu, Xi Liu

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121077 - 121077

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Impact of Microplastics in Food and Drugs on Human Health: A Review of the MENA Region DOI Open Access

Noha Alziny,

Fadya M. Elgarhy, Asmaa Eldesouky Mohamed

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(3), P. 380 - 380

Published: March 5, 2025

Microplastics (MPs), defined as plastic particles smaller than 5 mm, have emerged a global environmental and public health crisis, infiltrating air, water, soil, food systems worldwide. MPs originate from the breakdown of larger debris, single-use plastics, industrial processes, entering food. Emerging evidence underscores ability to cross biological barriers, including blood–brain barrier, triggering neuroinflammatory responses contributing neurodegenerative diseases such Alzheimer’s Parkinson’s. Polystyrene (PS), common type MP, activates microglial cells, releasing pro-inflammatory cytokines like tumor necrosis factor (TNF-α) interleukins, which increase neuronal damage. also been linked cardiovascular diseases, with studies detecting polyethylene (PE) polyvinyl chloride (PVC) in carotid artery plaques, increasing risk myocardial infarction stroke. Furthermore, disrupt endocrine function, alter lipid metabolism, induce gut microbiome imbalances, posing multifaceted risks. In MENA region, MP pollution is particularly severe, Mediterranean Sea receiving an estimated 570,000 tons annually, equivalent 33,800 bottles per minute. Studies Egypt, Lebanon, Tunisia document high concentrations marine ecosystems, herbivorous fish Siganus rivulatus containing over 1000 individual due ingestion contaminated seaweed. Despite these findings, awareness regulatory frameworks remain inadequate, only 24% Egyptians demonstrating sufficient knowledge safe use. This review emphasizes urgent need for region-specific research, policy interventions, campaigns address pollution. Recommendations include sustainable waste management practices, promotion biodegradable alternatives, enhanced monitoring mitigate impacts region.

Language: Английский

Citations

0
Urinary microplastic contaminants in primary school children: Associations with behavioral development DOI Creative Commons

Lingling Dong,

Xiang Li, Yue Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118097 - 118097

Published: April 1, 2025

Language: Английский

Citations

0
Polystyrene microplastics reduce honeybee survival by disrupting gut microbiota and metabolism DOI

Han Li,

Wangjiang Feng,

Tong An

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104704 - 104704

Published: April 1, 2025

Language: Английский

Citations

0
Microplastics: From Intrinsic Properties to Environmental Fate DOI
Maryam Salehi, Lauren N. Pincus, Baolin Deng

et al.

Environmental Engineering Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Language: Английский

Citations

2
Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks DOI Creative Commons
Sudipta Sankar Bora,

Rahul Gogoi,

Madhurjya Ranjan Sharma

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 25, 2024

Microplastics (MPs), defined as plastic particles smaller than 5 mm, are increasingly recognized environmental contaminants with potential health risks. These emerge breakdown products of larger plastics and omnipresent in marine, freshwater, terrestrial ecosystems. They primarily composed polymers such polyethylene, polypropylene, polystyrene, additives that enhance their performance. MPs also adsorb harmful chemicals like persistent organic pollutants heavy metals, posing risks to human health. Human exposure occurs mainly through ingestion inhalation, detected food products, water, even the air. have been shown accumulate gastrointestinal tract, disrupting gut microbiome, causing dysbiosis-a imbalance between beneficial bacteria. This disruption has linked various issues, including disorders, systemic inflammation, chronic diseases. Furthermore, gut-brain axis may be affected, neuroinflammatory consequences. As research continues unravel impacts MP exposure, understanding mechanisms accumulation broader implications on is crucial. review highlights effects health, emphasizing impact microbiome. We discuss connections cardiometabolic inflammatory diseases, disorders related Gut-Brain Axis. By synthesizing latest research, this work sheds light silent yet pervasive threat posed by underscores importance further studies understand fully.

Language: Английский

Citations

2