Human Leukocyte Antigen and microRNAs as Key Orchestrators of Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8544 - 8544

Published: Aug. 5, 2024

The expression of inflamma-miRs and human leukocyte antigen (HLA) haplotypes could indicate mild cognitive impairment (MCI) Alzheimer’s disease (AD). We used international databases to conduct a systematic review studies on HLA variants meta-analysis research microRNAs (miRNAs). aimed analyze the discriminative value miRNAs in MCI, AD controls evaluate protective or causative effect decline, establish role as biomarkers for early detection AD, find possible link between HLA. Statistical analysis was conducted using Comprehensive Meta-analysis software, version 2.2.050 (Biostat Inc., Englewood, NJ, USA). sizes were estimated by logarithm base 2 fold change. revealed that some variants, such HLA-B*4402, HLA-A*33:01, HLA-DPB1, HLA-DR15, HLA-DQB1*03:03, HLA-DQB1*06:01, HLA-DQB1*03:01, SNPs HLA-DRB1/DQB1, HLA-DQA1, predisposed decline before occurrence while HLA-A1*01, HLA-DRB1∗13:02, HLA-DRB1*04:04, HLA-DRB1*04:01 demonstrated role. identified let-7 miR-15/16 AD. association these two miRNA families predispose be screening prevention MCI.

Language: Английский

Exploring the Frontiers of Neuroinflammation: New Horizons in Research and Treatment

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(10), P. 11665 - 11667

Published: Oct. 19, 2024

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Language: Английский