Mercury Exposure and Health Effects: What Do We Really Know?

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2326 - 2326

Published: March 5, 2025

Mercury is widely used in medicine, agriculture, and industry. Meanwhile, according to the World Health Organization, it has been ranked as one of ten most hazardous substances world, with Agency for Toxic Substances Disease Registry ranking third. It no known positive functionality human body, even at low concentrations, can have harmful long-term health effects, seriously affecting healthcare system well posing a serious public threat. This review focuses on effects mercury its major sources environment. We highlight toxic role almost every possible aspect. forms, smallest doses, cause numerous disorders including nervous system, respiratory cardiovascular system. such various cancers; endothelial dysfunction; gastric vascular disorders; liver, kidney, brain damage; hormonal imbalances, miscarriages, reproductive skin lesions; vision death. The fact widespread use toxicity body prompts further in-depth research populations both moderate exposure. constant controlling monitoring problem, requiring urgent attention attentiveness from governments all countries and, long run, rapid concerted response. Thus, important analyze depth impact this highly metal prepare precisely targeted interventions among decision- policy-makers.

Language: Английский

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Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 142 - 142

Published: Jan. 24, 2025

Copper is an essential trace element, yet chronic copper exposure can lead to toxicity in humans, and high levels of have been found the blood or tumors patients with various forms cancer may affect severity response treatment. required for activation cytochrome c oxidase (CcO), mitochondrial complex that facilitates oxidative phosphorylation (OXPHOS)-mediated ATP production. We recently reported increased CcO underlies acquisition treatment resistance glioblastoma (GBM) cells. However, potential role GBM progression has not investigated. Here, we present evidence 20 µM copper, maximum allowable limit public water supplies set by U.S. Environmental Protection Agency, promotes tumor growth reduces overall survival vivo increases cell radiation chemotherapy vitro. In vitro substantially activity CcO, elevated rate level production, triggered a metabolic shift OXPHOS phenotype Furthermore, led substantial increase accumulation glutathione precursors these These findings establish as promoter suggest mediates effects through upregulation activity, which enhances metabolism

Language: Английский

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From micro to macro, nanotechnology demystifies acute pancreatitis: a new generation of treatment options emerges

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 29, 2025

Acute pancreatitis (AP) is a disease characterized by an acute inflammatory response in the pancreas. This caused abnormal activation of pancreatic enzymes variety etiologic factors, which results localized response. The symptoms this include abdominal pain, nausea and vomiting fever. These are induced hyperinflammatory oxidative stress. In recent years, research has focused on developing anti-inflammatory antioxidative therapies for treatment (AP). However, there still limitations to approach, including poor drug stability, low bioavailability short half-life. advent nanotechnology opened up novel avenue management Nanomaterials can serve as efficacious vehicle conventional pharmaceuticals, enhancing their targeting ability, improving prolonging Moreover, they also exert direct therapeutic effect. review begins introducing general situation It then discusses pathogenesis current status treatment. Finally, it considers literature related nanomaterials. objective study provide comprehensive existing use nanomaterials particular, changes markers outcomes following administration examined. done with intention offering insights that inform subsequent facilitate clinical application

Language: Английский

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Electronic Cigarette-Derived Metals: Exposure and Health Risks in Vapers

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Despite the popularity of electronic cigarettes (e-cigs) among adolescent and youth never-smokers adult smokers seeking a less harmful substitute for tobacco cigarettes, long-term health impact vaping is largely unknown. Biochemical, molecular, toxicological analyses biospecimens from e-cig users as well assays in relevant vitro models silico studies can identify chemical constituents emissions that may contribute to disease-causing potential vaping. E-cig aerosol contains wide range toxic carcinogenic compounds, which metals are particular concern. This due known or suspected role various pathogenesis numerous diseases. Many metalloids (herein referred "metals") have been detected liquid (e-liquid) and/or cells, tissues, biofluids, other specimens users. Metals contaminate ingredients e-liquid corrode internal components device. also be directly aerosolized surface heating element parts Inhalation metal habitual vapers nonusers through secondary exposure increase body burden chemicals. review summarizes state research on e-cig-derived their contributions estimated risks Highlighting composition aerosol, it focuses contents inhaled associated with this exposure. Emphasis placed adolescents who vulnerable populations bear disproportionate risk harm products. The gaps knowledge, methodological challenges, opportunities ahead discussed. importance translating findings into actionable information used regulation manufacturing products underscored.

Language: Английский

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A Proposal for Research Involving New Biomarkers of Hypertension, Lifestyle, and Environmental Exposure

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 206 - 206

Published: March 18, 2025

The constant monitoring of the population’s diet and assessment occupational exposure environmental impacts are key to determining health risks understanding factors contributing potential abnormalities in developing lifestyle diseases. Extensive long-term studies can provide data on population risks, including most common cardiovascular diseases like hypertension. This paper presents research recommendations for future researchers doctors improve diagnosis hypertension targeted, personalised treatment. proposal includes a study, diagnostic panel with new biomarkers, an men working metallurgical industry. New developments improved interventions constantly being sought, biomarkers high utility should enable early diagnosis, consequently allow appropriate and, importantly, therapy, prevent increase CVD deaths. Only effective treatment, reduce risk associated I propose that several parameters (NO, cfDNA, MPO, PCSK9, MyBPC3, microRNA, TAS, Pb, Cd) prognostic and/or predictive be included screening confirm need extensive testing middle-aged by healthcare professionals due

Language: Английский

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Heavy metal contamination of vegetables in China: status, causes, and impacts

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Language: Английский

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