Nuclear Factor Kappa B p65: A Possible Biomarker for Persistent Inflammation in HIV-1 Infection? DOI Open Access
Sivasubramaniyan Gnanaskandan, Padma Srikanth

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Low-grade inflammation in people living with HIV (PWH) has become a significant contributor to the development of non-communicable diseases (NCDs) such as heart disease, stroke, and renal dysfunction. Though antiretroviral therapy (ART) dramatically reduced mortality by limiting emergence opportunistic infections, it not been successful eliminating remaining chronic, low-grade activation that persists infected despite viral suppression better CD4+ T cell count. Nonetheless, this relatively asymptomatic subclinical chronic remains poorly understood major PWH. Another important component involved step is Nuclear Factor kappa B (NF-κB) which central transcription factor immune system respond infection. Specifically, p65/RELA subunit attaches LTR (long terminal repeat) gene consequently initiates synthesis genes related reactions. Persistent low-level contributes pathophysiology metabolic-inflammatory NCDs. Therefore, review aims assess complex contextual function NF-κB p65 during HIV-1 particularly among individuals on ART who achieve suppression. As much helped arrest progression virus, function, have reversed most It is, therefore, pertinent know how molecule those persistent concerns enhance strategies same. This will also discuss possible variation activity particular population groups MSM (men sex men) acquire additional information could potentially treatment.

Language: Английский

Traditional Chinese medicine as a promising choice for future control of PEDV DOI Creative Commons

Cheng-ye Ji,

Shuxuan Li,

Christine Hu

et al.

Virus Research, Journal Year: 2025, Volume and Issue: unknown, P. 199572 - 199572

Published: April 1, 2025

Porcine epidemic diarrhea virus (PEDV) is the major agent of recent outbreaks in piglets, which has caused huge economic losses to global swine industry. Since traditional vaccine strategies cannot provide complete protection for development safe, effective, and economical antiviral drugs urgently needed. For many years, Chinese medicines (TCMs) have been broadly applied viral infectious diseases, exhibiting advantages such as abundant resources, lower toxicity, minimal drug resistance. Many herbal monomers, single extracts derived from these drugs, recipes exhibit significant anti-PEDV effects vitro and/or vivo by targeting multiple sites perspectives, including inhibition life cycle, anti-inflammation effects, enhancement host immune response, modulation reactive oxygen species, apoptosis. However, date, no review published on TCM. Therefore, this summarizes current control PEDV systematically analyses research progress TCMs against PEDV. Furthermore, future directions integration nanotechnology artificial intelligence with are also discussed. This will a valuable reference studies research.

Language: Английский

Citations

0
Small Ruminant Lentiviruses Induce Systemic and Joint Oxidative Stress in Dairy Goats with Chronic Osteoarthritis DOI

Dominique Esther Machado Ferr Marsili,

R. da S. Carvalho,

Beatriz Nascimento Lins de Oliveira

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Naringenin alleviates heat stress-induced liver injury in Ningdu yellow chickens by decreasing RIPK3 and PDC binding DOI

Zhenni Liu,

Ruining Tang,

Qiurong Qi

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109894 - 109894

Published: March 1, 2025

Language: Английский

Citations

0
The Hallmarks of Ageing in Human Immunodeficiency Virus Infection and the Impact of Antiretroviral Therapy on Telomeres: A Molecular Perspective DOI Creative Commons

Miruna-Maria Apetroaei,

Stella Baliou, Πέτρος Ιωάννου

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 273 - 273

Published: April 12, 2025

Ageing is a complex and unavoidable physiological process which, in simple terms, consists of progressive deterioration the functionality cells, tissues organs, culminating an increased risk developing chronic pathologies. Telomeres, repetitive nucleotide structures at end chromosomes, ensure genomic integrity modulate cellular senescence. The shortening telomere length with each cell division directly correlates susceptibility to However, this shortening, normally inevitable, can be markedly accelerated presence infections, such as HIV-1 infection, by sustained continuous activation immune system, inflammation, generation oxidative stress, or direct alterations produced viral proteins. Thus, narrative review, we discuss 12 hallmarks ageing context understanding molecular changes induced through these well-established pillars could provide holistic approach management HIV-positive patients. At same time, considering that telomeres are centre all changes, assessment impact antiretroviral therapy on necessary guide clinical decisions. ultimate goal research develop personalised therapies increase quality life health outcomes HIV

Language: Английский

Citations

0
Nuclear Factor Kappa B p65: A Possible Biomarker for Persistent Inflammation in HIV-1 Infection? DOI Open Access
Sivasubramaniyan Gnanaskandan, Padma Srikanth

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Low-grade inflammation in people living with HIV (PWH) has become a significant contributor to the development of non-communicable diseases (NCDs) such as heart disease, stroke, and renal dysfunction. Though antiretroviral therapy (ART) dramatically reduced mortality by limiting emergence opportunistic infections, it not been successful eliminating remaining chronic, low-grade activation that persists infected despite viral suppression better CD4+ T cell count. Nonetheless, this relatively asymptomatic subclinical chronic remains poorly understood major PWH. Another important component involved step is Nuclear Factor kappa B (NF-κB) which central transcription factor immune system respond infection. Specifically, p65/RELA subunit attaches LTR (long terminal repeat) gene consequently initiates synthesis genes related reactions. Persistent low-level contributes pathophysiology metabolic-inflammatory NCDs. Therefore, review aims assess complex contextual function NF-κB p65 during HIV-1 particularly among individuals on ART who achieve suppression. As much helped arrest progression virus, function, have reversed most It is, therefore, pertinent know how molecule those persistent concerns enhance strategies same. This will also discuss possible variation activity particular population groups MSM (men sex men) acquire additional information could potentially treatment.

Language: Английский

Citations

1