Physicochemical Characterization of Hydroxyapatite Hybrids with Meloxicam for Dissolution Rate Improvement
Molecules,
Journal Year:
2024,
Volume and Issue:
29(11), P. 2419 - 2419
Published: May 21, 2024
Organic–inorganic
hybrids
represent
a
good
solution
to
improve
the
solubility
and
dissolution
rates
of
poorly
soluble
drugs
whose
number
has
been
increasing
in
last
few
years.
One
most
diffused
inorganic
matrices
is
hydroxyapatite
(HAP),
which
biocompatible
osteoconductive
material.
However,
understanding
hybrids’
functioning
mechanisms
many
cases
limited;
thus,
thorough
physicochemical
characterizations
are
needed.
In
present
paper,
we
prepared
pure
Mg-doped
with
meloxicam,
drug
pertaining
Biopharmaceutical
Classification
System
(BCS)
class
II,
i.e.,
low
high
permeability.
The
formation
was
demonstrated
by
FT-IR,
suggested
electrostatic
interactions
between
HAP
drug.
substitution
Mg
structure
mainly
produced
structural
disorder
reduction
crystallite
sizes.
surface
area
increased
after
doping
from
82
103
m2g−1
as
well
pore
volume,
justifying
slightly
amount
adsorbed
hybrid.
Notwithstanding
loading
on
hybrids,
solubility,
profiles
wettability
markedly
improved
respect
alone,
particularly
for
doped
one,
probably
due
main
distribution
surface.
Language: Английский
Effect of Nitric Acid on the Synthesis and Biological Activity of Silica–Quercetin Hybrid Materials via the Sol-Gel Route
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(12), P. 5268 - 5268
Published: June 18, 2024
The
sol-gel
technique
stands
out
as
a
valuable
method
for
synthesizing
biomaterials
and
encapsulating
bioactive
molecules,
offering
potential
controlled
drug
release
tissue
regeneration
in
biomedical
contexts.
This
study
focused
on
silica
(Si)-based
hybrid
containing
5%
quercetin
(Q5)
using
two
different
approaches:
one
involving
nitric
acid
catalyst
(SiQ5-HNO3)
the
other
being
acid-free
(SiQ5).
Structural
characterization
Fourier
transform
infrared
(FTIR)
UV-vis
spectroscopy
revealed
oxidation
processes
compromising
structural
integrity
of
both
systems.
However,
it
was
observed
that
these
led
to
formation
oxidized
derivatives
with
distinct
structures.
Additionally,
bioactivity
kinetics
from
matrices
were
evaluated,
showing
systems
capable
forming
hydroxyapatite,
indicating
excellent
bioactivity.
Furthermore,
SiQ5
exhibited
higher
percentage
encapsulated
at
pH
7.4,
representing
physiological
environment,
compared
SiQ5-HNO3,
drastic
reduction
5.0
(cancer
environment).
Antibacterial
efficacy
assessment
Kirby–Bauer
test
highlighted
greater
antibacterial
activity
SiQ5-HNO3
system
against
all
tested
strains.
Overall,
this
research
aims
advance
development
more
effective
various
applications,
particularly
engineering
infection
control.
Language: Английский
Characterization of Grape Extract-Colored SiO2 Synthesized via the Sol–Gel Method
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(24), P. 11697 - 11697
Published: Dec. 15, 2024
Numerous
studies
have
focused
on
the
development
of
active
packaging
using
plastics,
but
glass-based
represents
a
more
sustainable
alternative,
offering
advantages
in
terms
recyclability,
durability,
and
reduced
environmental
footprint.
This
study
proposes
system
by
incorporating
anthocyanins-rich
grape
extract
(GRE)
into
silica
(SiO2)
matrix
sol–gel
method.
GRE
was
added
at
two
concentrations,
5%
(S5GRE)
15%
(S15GRE).
During
synthesis,
color
brightening
occurred
as
anthocyanins
shifted
to
colorless
chalcone
pseudo-base
forms,
colorimetric
analysis
confirmed
that
hybrid
materials
retained
red
hue
after
gel
drying.
Fourier-transform
infrared
(FTIR)
thermogravimetric
(TGA/DTG)
investigated
stability
within
showed
both
hybrids
formed
hydrogen
bonds
with
inorganic
matrix.
However,
S5GRE
exhibited
better
thermal
compared
S15GRE,
possibly
due
greater
proportion
being
fully
entrapped
rather
than
surface-bound.
The
encapsulation
efficiency
supported
this,
showing
98.12%
successfully
S5GRE,
whereas
S15GRE
only
54.62%.
These
results
indicate
that,
while
exhibits
higher
allows
for
faster
release,
releases
less
efficiently
aggregation
Language: Английский