Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress DOI Creative Commons
Anil Patani, Deepak Balram, Virendra Kumar Yadav

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 30, 2023

Oxidative stress, resulting from dysregulation in the secretion of adrenal hormones, represents a major concern human health. The present review comprehensively examines various categories endocrine within glands, encompassing glucocorticoids, mineralocorticoids, and androgens. Additionally, comprehensive account hormone disorders, including insufficiency, Cushing’s syndrome, tumors, is presented, with particular emphasis on their intricate association oxidative stress. also delves into an examination nutritional antioxidants, namely vitamin C, E, carotenoids, selenium, zinc, polyphenols, coenzyme Q10, probiotics, elucidates role mitigating adverse effects stress arising imbalances levels. In conclusion, harnessing power antioxidants has potential to help caused by imbalance hormones. This could lead new research therapeutic interventions.

Language: Английский

Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota DOI Open Access
Tamara Lippolis, Miriam Cofano, Giusy Rita Caponio

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3813 - 3813

Published: Feb. 14, 2023

It is generally accepted that diet-derived polyphenols are bioactive compounds with several potentially beneficial effects on human health. In general, have chemical structures, and the most representative flavonoids, phenolic acids, stilbenes. should be noted of closely related to their bioavailability bioaccessibility, as many them rapidly metabolized after administration. Polyphenols—with a protective effect gastrointestinal tract—promote maintenance eubiosis intestinal microbiota against gastric colon cancers. Thus, benefits obtained from dietary supplementation would seem mediated by gut microbiota. Taken at certain concentrations, been shown positively modulate bacterial component, increasing Lactiplantibacillus spp. Bifidobacterium involved in protection barrier decreasing Clostridium Fusobacterium, which negatively associated well-being. Based diet–microbiota–health axis, this review aims describe latest knowledge action health through activity discusses micro-encapsulation strategy improve

Language: Английский

Citations

85

Antimicrobial Activities of Natural Bioactive Polyphenols DOI Creative Commons

Manas Kumar Mandal,

Abraham J. Domb

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 718 - 718

Published: May 27, 2024

Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety biological functions natural environment. These uses include polyphenols food, beauty products, dietary supplements, and medicinal products grown rapidly during past 20 years. Antimicrobial described together with their sources, classes, subclasses. Polyphenols found different such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples benefits antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, antimicrobe properties. From these classes helpful for growth internal functional systems human body, providing healthy fats, vitamins, minerals, lowering risk cardiovascular diseases, improving brain health, rebooting our cellular microbiome health by mitochondrial uncoupling. Among various (curcumin, naringenin, quercetin, catechin, etc.) primarily antimicrobial activities discussed along possible future applications. For agents to be proven safe, adverse impacts must substantiated reliable scientific research well vitro vivo clinical data. Future may influenced this evaluation.

Language: Английский

Citations

27

Polyphenols: Secondary Metabolites with a Biological Impression DOI Open Access
Ecem Bolat, Sümeyye Sarıtaş, Hatice Duman

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2550 - 2550

Published: Aug. 3, 2024

Polyphenols are natural compounds which plant-based bioactive molecules, and have been the subject of growing interest in recent years. Characterized by multiple varieties, polyphenols mostly found fruits vegetables. Currently, many diseases waiting for a cure or solution to reduce their symptoms. However, drug other chemical strategies limitations using treatment agent still detection tool diseases, thus researchers need investigate preventive improving treatment. Therefore, it is elucidate polyphenols, bioactivity effects, supplementation, consumption. The disadvantage that they limited bioavailability, although beneficial outcomes with roles. In this context, several different developed improve particularly liposomal nanoparticles. As nutrition one most important factors health, inclusion molecules daily diet significant continues be enthusiastically researched. Nutrition, individuals all ages, key polyphenols.

Language: Английский

Citations

24

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy DOI Creative Commons
Mohamed El Oirdi

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 692 - 692

Published: May 27, 2024

There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.

Language: Английский

Citations

21

Resveratrol: A comprehensive review of its multifaceted health benefits, mechanisms of action, and potential therapeutic applications in chronic disease DOI

Akash Vikal,

Rashmi Maurya, Shuvadip Bhowmik

et al.

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: 3, P. 100047 - 100047

Published: April 21, 2024

Language: Английский

Citations

19

Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review DOI Creative Commons
Luca Rossi, Gabriele Rocchetti, Luigi Lucini

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 200 - 200

Published: Feb. 10, 2025

Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, extending shelf life. The effectiveness of PPs has different molecular biological reasons, predominantly linked to their hydroxyl groups electron delocalization, which interact with microbial cell membranes, proteins, organelles. These interactions may reduce the efficiency metabolic pathways, cause destructive damage membrane, or they harm proteins nucleic acids foodborne bacteria. Moreover, exhibit distinctive ability form complexes metal ions, further amplifying activity. This narrative review explores complex multifaceted between pathogens, underlying correlation chemical structures mechanisms action. Such insights shed light on potential innovative natural preservatives within systems, presenting an eco-friendly sustainable alternative synthetic additives.

Language: Английский

Citations

15

Polyphenol-Protein Particles: A Nutraceutical Breakthrough in Nutrition and Food Science DOI Creative Commons
Sidra Tul-Muntaha, Allah Rakha,

Hina Rasheed

et al.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101641 - 101641

Published: Jan. 1, 2025

Language: Английский

Citations

12

Health-Improving Effects of Polyphenols on the Human Intestinal Microbiota: A Review DOI Open Access
Boris Nemzer, Fadwa Al-Taher,

Diganta Kalita

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1335 - 1335

Published: Feb. 5, 2025

Dietary polyphenols are garnering attention in the scientific community due to their potential health-beneficial properties and preventative effects against chronic diseases, viz. cardiovascular diabetes, obesity, neurodegenerative diseases. Polyphenols antioxidants that change microbial composition by suppressing pathogenic bacteria stimulating beneficial bacteria. The interaction of with dietary fibers affects bioaccessibility upper lower parts digestive tract. fibers, polyphenols, conjugates, metabolites modulate microbiome population diversity. Consuming polyphenol-rich such as pomegranate, cranberry, berries, tea improves gut health. A complex relationship exists between diets microbiota for functioning human In this review, we provide an overview interactions microbiota, improving understanding functional polyphenols.

Language: Английский

Citations

6

Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin DOI Creative Commons
Leonel Pereira, João Cotas

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(6), P. 323 - 323

Published: May 26, 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.

Language: Английский

Citations

44

The efficacy of polyphenols as an antioxidant agent: An updated review DOI
Mohamed E. Abd El‐Hack, Maria Cristina de Oliveira, Youssef A. Attia

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 250, P. 126525 - 126525

Published: Aug. 25, 2023

Language: Английский

Citations

34