Green Processing and Synthesis,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: Jan. 1, 2025
Abstract
In
this
study,
zinc
oxide
nanoparticles
(ZnO-NPs)
were
biosynthesized
from
methanolic
stem
extract
of
Andrographis
paniculata
(MEAP)
and
characterized
physicochemically.
ZnO-NPs
evaluated
biologically
for
anti-diabetic
anti-nephropathy
activities.
A
diabetic
rat
model
generated
by
streptozotocin
was
used
to
test
the
properties
ZnO-NPs.
rats,
oral
doses
MEAP
given
once
daily
30
days
at
100,
200,
300,
400,
600,
1,200
mg·kg
−1
,
respectively.
Metformin,
a
common
antidiabetic
drug,
utilized
as
control
dosage
250
.
The
NPs
mediated
homogenous,
stable,
spherical,
tiny.
MEAP-derived
prevented
weight
loss
while
significantly
(
p
<
0.05)
lowering
blood
glucose
levels
in
comparison
and,
lesser
extent,
metformin.
Furthermore,
MEAP-mediated
found
have
favorable
effects
on
lipid
profile
nephropathy.
histopathological
evaluation
demonstrated
safety,
non-toxicity,
biocompatibility
synthesized
produced
MEAP.
hypoglycemic
response
greater
400
·day
than
it
200
100
Therefore,
exhibit
more
action
first
experimental
setting
reported.
Journal of Biomedical Science,
Journal Year:
2023,
Volume and Issue:
30(1)
Published: June 19, 2023
The
global
burden
of
invasive
fungal
infections
(IFIs)
has
shown
an
upsurge
in
recent
years
due
to
the
higher
load
immunocompromised
patients
suffering
from
various
diseases.
role
early
and
accurate
diagnosis
aggressive
containment
infection
at
initial
stages
becomes
crucial
thus,
preventing
development
a
life-threatening
situation.
With
changing
demands
clinical
mycology,
field
diagnostics
evolved
come
long
way
traditional
methods
microscopy
culturing
more
advanced
non-culture-based
tools.
advent
powerful
approaches
such
as
novel
PCR
assays,
T2
Candida,
microfluidic
chip
technology,
next
generation
sequencing,
new
biosensors,
nanotechnology-based
tools,
artificial
intelligence-based
models,
face
is
constantly
for
better.
All
these
advances
have
been
reviewed
here
giving
latest
update
our
readers
most
orderly
flow.A
detailed
literature
survey
was
conducted
by
team
followed
data
collection,
pertinent
extraction,
in-depth
analysis,
composing
sub-sections
final
review.
review
unique
its
kind
it
discusses
molecular
methods;
serology-based
biosensor
technology;
machine
learning-based
all
under
one
roof.
To
best
knowledge,
there
no
covering
fields
(especially
technology
learning
using
intelligence)
with
relevance
infections.The
will
undoubtedly
assist
updating
scientific
community's
understanding
advancements
that
are
on
horizon
may
be
implemented
adjuncts
diagnostic
algorithms.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101368 - 101368
Published: Jan. 1, 2024
Zinc
oxide
nanoparticles
(ZnO
NPs)
exhibit
distinctive
characteristics,
making
them
highly
sought-after
in
many
sectors.
Nevertheless,
conventional
techniques
for
producing
ZnO-NPs
are
linked
to
environmental
and
health
hazards
due
toxic
substances.
In
this
review,
we
study
zinc
synthesized
from
plant
extracts
their
subsequent
biomedical
uses
detail.
Research
shows
that
several
different
employed
manufacturing
ZnO
nanoparticles.
Leaves,
fruits,
seeds,
roots,
complete
plants
all
included
these
extracts.
Phytochemicals
such
as
phenolic
compounds,
alkaloids,
flavonoids,
terpenoids
a
part
of
biological
matrices.
compounds
show
bioreduction
mechanism,
act
stabilizing
reducing
agent.
The
attributes
(NPs),
including
size,
shape,
crystallinity,
may
be
altered
by
adjusting
the
extract
variety,
concentration,
synthesis
conditions.
Consequently,
formed
display
notable
diversity
physical
chemical
subsequently
impacting
functionality.
manufactured
using
green
methods
extensive,
beneficial
effects
antibacterial
activity
against
various
pathogens,
anti-inflammatory
possible
anticancer
activities.
Nanoparticles
have
been
integrated
into
wound
dressings,
used
carriers
medication
delivery,
utilized
biosensing
imaging
applications.
enhanced
biocompatibility
reduced
toxicity
green-processed
techniques,
comparison
those
made
approaches,
make
very
appealing
use
contexts.
Moreover,
paper
examines
mechanisms,
explicitly
focusing
on
involvement
phytochemicals
processes
reduction
stabilization.
Additionally,
emphasizes
difficulties
potential
future
directions
optimizing
processes,
increasing
capacity,
facilitating
therapeutic
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 768 - 768
Published: Feb. 7, 2025
Multidrug-resistant
(MDR)
Escherichia
coli
is
a
major
foodborne
pathogen
posing
critical
threat
to
public
health,
particularly
through
the
contamination
of
animal
products.
The
increasing
prevalence
and
virulence
MDR
E.
strains
underscore
urgent
need
for
alternative
antimicrobial
strategies.
This
study
aimed
synthesize
characterize
zinc
oxide
nanoparticles
(ZnO-NPs)
using
Stevia
rebaudiana
as
sustainable
capping
reducing
agent,
aligning
with
green
chemistry
principles.
Of
120
fish
samples,
74.2%
(89/120)
were
positive
contamination.
Among
identified
strains,
77.8%
(119/153)
classified
MDR.
Resistance
profiling
revealed
22
distinct
patterns,
seven
highly
resistant
virulent
selected
further
analyses.
eco-friendly
auto-combustion
synthesis
ZnO-NPs
produced
semi-spherical
hexagonal
shapes
an
average
size
ranging
from
12
25
nm.
Scanning
Electron
Microscope-Energy
Dispersive
X-ray
analysis
(SEM-EDS)
confirms
that
primarily
consist
(37.5%)
oxygen
(19.9%),
carbon
(42.6%)
indicating
process.
demonstrated
potent,
dose-dependent
antibacterial
antibiofilm
activity
against
strains.
Additionally,
mechanistic
studies
disrupt
bacterial
cell
membranes,
alter
cellular
morphology,
interfere
DNA
integrity.
These
findings
highlight
potential
promising
nanomaterial
enhancing
food
safety
addressing
growing
challenge
bacteria.
Crystals,
Journal Year:
2022,
Volume and Issue:
12(8), P. 1057 - 1057
Published: July 29, 2022
The
high
frequency
of
nosocomial
bacterial
infections
caused
by
multidrug-resistant
pathogens
contributes
to
significant
morbidity
and
mortality
worldwide.
As
a
result,
finding
effective
antibacterial
agents
is
critical
importance.
Hence,
the
aim
present
study
was
greenly
synthesize
silver
nanoparticles
(AgNPs)
utilizing
Salvia
officinalis
aqueous
leaf
extract.
biogenic
AgNPs
were
characterized
different
physicochemical
techniques
such
as
energy-dispersive
X-ray
spectroscopy
(EDX),
ultraviolet-visible
spectrophotometry
(UV-Vis),
diffraction
analysis
(XRD),
transmission
electron
microscopy
(TEM),
Fourier
transform
infrared
(FT-IR)
analysis.
Additionally,
synergistic
antimicrobial
effectiveness
biosynthesized
with
colistin
antibiotic
against
strains
evaluated
standard
disk
diffusion
assay.
bioformulated
revealed
features,
small
particle
size
17.615
±
1.24
nm
net
zeta
potential
value
−16.2
mV.
elemental
mapping
that
main
element,
recording
relative
mass
percent
83.16%,
followed
carbon
(9.51%),
oxygen
(5.80%),
silicon
(0.87%),
chloride
(0.67%).
disc
assay
showed
potency
tested
pathogens,
highest
efficiency
Escherichia
coli
strain
an
inhibitory
zone
diameter
37.86
0.21
mm
at
concentration
100
µg/disk.
In
addition,
activity
significantly
higher
than
(p
≤
0.05)
multidrug
resistant
namely,
Acinetobacter
baumannii.
antibiotic,
demonstrating
A.
baumannii
(85.57%)
Enterobacter
cloacae
(53.63%),
E.
(35.76%),
Klebsiella
pneumoniae
(35.19%),
Salmonella
typhimurium
(33.06%),
Pseudomonas
aeruginosa
(13.75%).
conclusion,
unique
characteristics
activities
pathogens.
Consequently,
potent
effect
AgNPs–colistin
combination
highlights
this
for
fabrication
highly
coatings
in
intensive
care
units
successful
control
spread
infections.
Nanotechnology Reviews,
Journal Year:
2023,
Volume and Issue:
12(1)
Published: Jan. 1, 2023
Abstract
Green
synthesis
of
zinc
oxide
(ZnO)
nanoparticles
(NPs)
using
various
plant
extracts
as
reducing
and
capping
agents
has
gained
attention
in
recent
research.
The
green
ZnO
NPs
offers
several
advantages
such
being
simple,
eco-friendly,
safe,
cost-effective,
reproducible
approach
with
high
stability.
Hence,
this
article
provides
an
overview
metal
compounds,
traditional
chemical
physical
primary
focuses
on
the
NPs.
This
study
discusses
used
proposed
mechanisms
Additionally,
it
explores
cytotoxic
green-synthesized
addresses
biomedical
applications
NPs,
including
antibacterial,
anticancer,
antidiabetic,
antioxidant,
antifungal,
antiviral,
antiparasitic,
anti-inflammatory,
wound
healing.
Moreover,
review
critically
toxicity
emphasizes
need
for
more
toxicological
studies
to
ensure
safety
facilitate
risk
assessments
management
Furthermore,
underlines
challenges
associated
translation
process
from
bench
market,
complex
time-consuming
regulatory
approval
which
requires
a
multidisciplinary
involving
scientists,
regulators,
manufacturers.
Infection and Drug Resistance,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 125 - 142
Published: Jan. 1, 2023
A
considerable
number
of
morbidities
and
fatalities
occur
worldwide
as
a
result
the
multidrug
resistant
microorganisms
that
cause
high
prevalence
nosocomial
bacterial
infections.
Hence,
current
investigation
was
conducted
to
evaluate
antibacterial
potency
green
fabricated
silver
nanoparticles
(AgNPs)
against
four
different
pathogens.The
flower
extract
Hibiscus
sabdariffa
mediated
fabrication
AgNPs
their
physicochemical
features
were
scrutinized
using
techniques.
Antimicrobial
activity
biogenic
synergistic
patterns
with
fosfomycin
antibiotic
evaluated
disk
diffusion
assay.UV
spectral
analysis
affirmed
successful
formation
through
detection
broad
absorption
band
at
395
524
nm,
indicating
surface
plasmon
resonance
biofabricated
AgNPs.
In
this
setting,
demonstrated
average
particle
size
58.682
nm
according
transmission
electron
microscope
(TEM)
micrographs.
The
detected
hydrodynamic
diameter
higher
than
noticed
by
TEM
analysis,
recording
72.30
in
could
be
attributed
action
capping
agents,
which
confirmed
Fourier
Transform
Infrared
(FT-IR)
analysis.
Disk
assay
indicated
(50
μg/disk)
Enterobacter
cloacae,
Methicillin-resistant
Staphylococcus
aureus,
Klebsiella
pneumoniae
Escherichia
coli
strains
relative
inhibition
zone
diameters
12.82
±
0.36
mm,
14.54
0.15
18.35
0.24
mm
21.69
0.12
respectively.
addition,
E.
found
most
susceptible
strain
However,
highest
pattern
AgNPs-fosfomycin
combination
K.
pneumonia
percentage
64.22%.
conclusion,
efficiency
highlight
potential
for
utilizing
biofabrication
effective
agents
pathogens.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(4), P. 945 - 945
Published: April 4, 2023
Nosocomial
bacterial
and
fungal
infections
are
one
of
the
main
causes
high
morbidity
mortality
worldwide,
owing
to
prevalence
multidrug-resistant
microbial
strains.
Hence,
study
aims
synthesize,
characterize,
investigate
antifungal
antibacterial
activity
silver
nanoparticles
(AgNPs)
fabricated
using
Camellia
sinensis
leaves
against
nosocomial
pathogens.
The
biogenic
AgNPs
revealed
a
small
particle
diameter
35.761
±
3.18
nm
based
on
transmission
electron
microscope
(TEM)
graphs
negative
surface
charge
-14.1
mV,
revealing
repulsive
forces
between
nanoparticles,
which
in
turn
indicated
their
colloidal
stability.
disk
diffusion
assay
confirmed
that
Escherichia
coli
was
most
susceptible
strain
(200
g/disk),
while
lowest
sensitive
found
be
Acinetobacter
baumannii
with
relative
inhibition
zones
36.14
0.67
21.04
0.19
mm,
respectively.
On
other
hand,
µg/disk)
exposed
efficacy
Candida
albicans
zone
18.16
0.14
mm
diameter.
synergistic
both
tigecycline
clotrimazole
A.
C.
albicans,
In
conclusion,
demonstrated
distinct
physicochemical
properties
potential
bioactivity
tigecycline,
linezolid,
gram-negative,
gram-positive,
strains,
This
is
paving
way
for
development
effective
antimicrobial
combinations
management
pathogens
intensive
care
units
(ICUs)
health
settings.
Materials,
Journal Year:
2024,
Volume and Issue:
17(17), P. 4340 - 4340
Published: Sept. 2, 2024
The
green
synthesis
of
ZnO
NPs
is
becoming
increasingly
valued
for
its
cost-effectiveness
and
environmental
benefits.
This
study
successfully
synthesized
hexagonal
using
a
combination
clove
(
