Synergistic Antifungal Efficiency of Eco-Friendly Synthesized Zinc Oxide Nanoparticles in Combination with Fluconazole against Drug-Resistant Candidal Strains DOI Open Access
Mohamed Taha Yassin,

Fatimah Olyan Al-Otibi,

Khalid Maniah

et al.

Polish Journal of Environmental Studies, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

The resistance of fungal pathogens to traditional antifungal medications presents a significant public health concern, particularly for immunocompromised patients, leading elevated rates illness and death.This study aimed explore the properties zinc oxide nanoparticles (ZnO NPs) produced using natural approach involving aqueous seed extract Trigonella foenumgracium (Fenugreek).Additionally, assessed combined effectiveness these biologically synthesized ZnO NPs with fluconazole against pathogens.The were observed have hexagonal shape an average diameter 27 nm surface charge -18.3 mV.Notably, exhibited most potent activity Candida tropicalis, relative inhibition zone 18.67±0.56mm.The minimum inhibitory concentration C. tropicalis was determined be 100 µg/mL, while fungicidal found 200 µg/mL.The greatest synergistic effect between glabrata, followed by parapsilosis.In summary, underscores potential combining formulate effective treatment drug-resistant pathogens, thereby enhancing therapeutic efficacy conventional drugs.

Language: Английский

Metal oxide nanoparticles: Synthesis and applications in energy, biomedical, and environment sector DOI Creative Commons

Samreen Afzal,

Sultan Ullah,

Misbah Shahid

et al.

Journal of the Chinese Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Metal oxide nanoparticles (MONPs), pivotal in cutting‐edge research, are examined comprehensively this article. Encompassing definition, types, and applications, the focus intensifies on synthesis methods. Detailed discussions include chemical approaches for silver oxide, zinc nickel copper tin NPs. Additionally, article emphasizes burgeoning significance of green methods tailoring these The applications section underscores their role wastewater treatment, water splitting, biomedical fields. This targeted resource offers in‐depth insights into MONP synthesis, bridging gap between traditional environmentally conscious methodologies, researchers practitioners emerging technologies. In article, future perspectives also discussed.

Language: Английский

Citations

5

Anti-proliferative activity of biosynthesized zinc oxide nanoparticles against breast cancer MCF-7 cells DOI

P. Shubha,

S. Ganesh,

Shyam Sundar S

et al.

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 315, P. 128900 - 128900

Published: Jan. 13, 2024

Language: Английский

Citations

4

The cytotoxic potency of green synthesis of zinc oxide nanoparticles (ZnO-NPs) using Origanum majorana DOI
Abdallah S. Abdelsattar,

Azza G. Kamel,

Mohamed Atef Eita

et al.

Materials Letters, Journal Year: 2024, Volume and Issue: 367, P. 136654 - 136654

Published: May 15, 2024

Language: Английский

Citations

4

Green-synthesized zinc oxide nanoparticles from Garcinia mangostana leaf extract: A promising antibacterial agent for poultry DOI Creative Commons
Ridho Kurniawan Rusli,

Zurmiati Zurmiati,

Rita Mutia

et al.

Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 263 - 269

Published: Feb. 1, 2025

Background and Aim: The development of zinc-based antimicrobials has progressed from conventional to nanoparticle (NP) formulations due their enhanced biological properties. This study evaluates the antibacterial efficacy green-synthesized zinc oxide NPs (ZnO-NPs) derived Garcinia mangostana leaf extract against both pathogenic non-pathogenic bacteria relevant poultry health. Materials Methods: Using a completely randomized design, six treatment groups were tested: Positive control (PC) (tetracycline, 2.5 mg/mL), negative (NC) (HCl 0.1 N + distilled water), ZnO-NPs at concentrations 2.5, 5, 7.5, 10 mg/mL. antimicrobial activity was assessed using agar well diffusion method, measuring inhibition zones Escherichia coli, S. Typhimurium, Staphylococcus aureus, Lactobacillus plantarum. Results: positive demonstrated most significant across all bacterial strains. exhibited dose-dependent activity, with maximum recorded as 18.58 mm for E. 17.09 17.41 aureus highest concentration (10 mg/mL). However, L. plantarum less pronounced, zone 9.93 mm. These findings indicate selective toxicity ZnO-NPs, favoring over Conclusion: Green-synthesized G. demonstrate promising properties pathogens. Their action highlights potential applications eco-friendly feed additives improve health mitigate risks. Keywords: antibacterial, green synthesis, nanotechnology, health, nanoparticles.

Language: Английский

Citations

0

Green Synthesis of Zinc Nanoparticles using leaf extract of Clitoria ternatea and Evaluation of its Antimicrobial and Anti-oxidant Activity DOI Creative Commons

Dibya Rana Saha Roy,

Razia Aman,

Umesh Chand

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100290 - 100290

Published: March 1, 2025

Language: Английский

Citations

0

Large-scale production of myco-fabricated ZnO/MnO nanocomposite using endophytic Colonstachys rosea with its antimicrobial efficacy against human pathogens DOI Creative Commons
Shahira H. EL‐Moslamy, Ahmed I. Abd-Elhamid, Gomaa El Fawal

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 10, 2024

Abstract In this study, a ZnO/MnO nanocomposite was myco-fabricated using the isolated endophytic Clonostachys rosea strain EG99 as nano-factory. The extract of EG99, reducing/capping agent, successfully titrated with equal quantities Zn(NO 3 ) 2 ·6H O and Mn(NO (precursors) in single step to fabricate rod-shaped size 6.22 nm. 20 min, results were validated at 350 400 nm UV–Vis spectroscopy. 7-L bioreactor, an industrial biotechnological approach used scale up biomass strain, yield nanocomposite. A controlled fed-batch fermentation system specific nitrogen/carbon ratio identical feeding schedule production process. Higher yields obtained by adopting bioreactor regular 1:200. Overall, produced 89.2 g/l its maximum, 2.44 times more than batch's 36.51 output. Furthermore, fed-batch's maximum 79.81 g/l, noteworthy 14.5-fold increase over 5.52 g/l. Finally, we designed innovative manage growth mode, supporting rapid, cheap eco-friendly myco-fabrication At dose 210 µg/ml, tested exhibited antibacterial activity against Staphylococcus aureus (98.31 ± 0.8%), Escherichia coli (96.70 3.29%), Candida albicans (95.72 0.95%). same dose, biofilm eradicated 48 h; however, biofilms needed 72 96 h, respectively. Our showed strong highly selective antagonistic effects variety multidrug-resistant human pathogens. Therefore, upcoming generations antibiotics, it might be employed nano-antibiotic.

Language: Английский

Citations

3

An effective and sustainable dye removal via sunlight-based photocatalysis and adsorption using eco-friendly and low-cost ZnS nanoparticles: Experiments, modelling, and mechanism DOI Creative Commons

Sabri Ouni,

Faiza Yahia,

Naim Bel Haj Mohamed

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

Abstract Novel sulfur zinc nanoparticles functionalized with thioglycolic acid were synthetized via hydrothermal route and tested in a solar radiation-based dye photodegradation process. These characterized, the findings revealed that was strong capping ligand for generation of specific surface area 36.82 m 2 /g 7.15 nm average nanocrystal size. The cubic wurtzite phases these confirmed X-ray diffraction. quantum confinement effect caused larger energy band gap blue shift absorbance contrast to bulk zinc. improved adsorption effectiveness proved remove methylene from aqueous solutions. They can 30.92 mg/g molecule. To understand synergy between photocatalysis, used analyze prior experimental measurement isotherms kinetics. rationalization on performed calculated statistical physics parameters including estimation – energy. Dye molecules exhibited physical interactions energies 25.92–23.31 kJ/mol. sunlight-based photocatalytic activity demonstrated 91.1% degradation efficiency 180 min. Overall, remained almost unchanged after five consecutive cycles 88 ± 3%. results indicate sustainable be applied cleaning industrial urban fluids polluted by hazardous organic compounds like molecules.

Language: Английский

Citations

3

Biosynthesis of Zinc Oxide Nanoparticles by Origanum majorana Aqueous Leaves Extracts, Characterization and Evaluated Against to Schistosoma haematobium DOI Open Access
Samah S. Eldera,

Lila A. Alkhtaby,

Reem Al‐Wafi

et al.

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(2)

Published: Jan. 24, 2025

ABSTRACT Schistosomiasis, caused by Schistosoma worms, is a major neglected tropical disease in Africa, this ranked as second after malaria. Nanotechnology important for treating schistosomiasis while minimizing chemotherapy side effects. The current investigate aimed to assess the effectiveness of biosynthesized zinc oxide nanoparticles (ZnO NPs), which were used first time an attempt find alternative treatment and synthesized Origanum majorana , compare them with praziquantel (PZQ), only chemical approved World Health Organization. study included evaluations both laboratory vivo. In experiment, adult worms exposed ZnO at concentrations 100, 50, 25, 12.5, 6.25, 3.125 μg/mL showed highest complete mortality rates 100 50 6 12 h, respectively. Combinations 12.5 + 0.4, 25 0.3, 0.2, 75 0.1 PZQ also tested. vivo, four groups hamsters infected haematobium treated. hamsters, number eggs present tissues well size granulomas significantly decreased when combined administered. properties particles consistent confirmed all previous studies. These results indicate that green high activity against S . experiments.

Language: Английский

Citations

0

Green-Synthesized Zinc Oxide Nanoparticles for Acinetobacter baumannii Control: A Review of Plant-Based Approaches DOI Open Access

Omar I Khalif,

Esam J. Al-Kalifawi

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

Citations

0

Semi-industrial Bio-fabrication of ZnO/MnO2 Nanocomposite Using Endophytic Streptomyces coelicolor: Characterization, Statistical Design, Exponential Pulse Fed-Batch Fermentation, and Its Antimicrobial Application DOI Creative Commons
Shahira H. EL‐Moslamy,

Ahmed H. Rezk,

Marwa Elkady

et al.

Arabian Journal for Science and Engineering, Journal Year: 2024, Volume and Issue: 49(7), P. 9067 - 9088

Published: Jan. 29, 2024

Abstract In our study, we examined how well six Streptomyces strains bio-fabricated ZnONPs, MnONPs, and/or ZnO/MnO 2 nanocomposite. The most potent strain that generated efficient antimicrobial nanoparticles was then picked to increase the production of those particles in a semi-industrial pilot plant unit. Consequently, intracellular extract endophytic coelicolor E72 used achieve bio-fabrication reaction spherical nanocomposite (6–18 nm). validated and characterized using FTIR, XRD, SEM, TEM, TGA, EDS analyses. Additionally, this nanocomponent scaled up unit with size. Plackett–Burman experimental method maximize nanocomposites, which had increased 2.7-fold from their initial state. subsequently 31.25 times an exponential pulse-feeding fermentation technique 70-L bioreactor. This exhibited effective efficacy against all tested antibiotic-resistant human pathogens. effects Salmonella paratyphi (53.17 ± 2.8 mm) Candida albicans (50.2 1.01 were at 90 130 µg/ml nanocomposite, respectively. is first full explanation scale employing as reducing/capping agent reacted MnCl ·4H O Zn (CH 3 COO) ·2H precursors. has potential be utilized development pharmaceuticals, cosmetics, wound dressings, burn therapy due its powerful capabilities.

Language: Английский

Citations

3