Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 5, 2023
Abstract
This
research
article
investigates
the
impact
of
three
input
variables,
including
Cu
Composition
(%),
Heating
Temperature
(C),
and
Milling
Time
(h),
on
final
production
copper-tin
alloy
nanoparticles
for
first
time.
The
study
uses
design
experiments
techniques
measures
output
responses,
Particle
Size
(nm),
Optical
Density
(ppm),
Number
Colonies.
identifies
presence
new
3
Sn
phases
in
structure
nanoparticles.
results
demonstrate
that
all
factors
have
a
significant
nanoparticle
production,
with
mechanical
alloying
effectively
producing
powders
up
to
15
nanometers
size.
reveals
increasing
percentage
copper
leads
stronger
antibacterial
properties,
as
demonstrated
by
increased
optical
density
decreased
colony
counts.
work
provides
valuable
insights
into
properties
influence
variables
their
properties.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11563 - 11563
Published: Oct. 28, 2024
The
use
of
metal
and
oxide
nanoparticles
is
frequently
regarded
as
a
potential
solution
to
the
issue
bacterial
antibiotic
resistance.
Among
proposed
range
with
antibacterial
properties,
copper
are
particular
interest.
Although
properties
have
been
known
for
considerable
period
time,
studies
on
effects
nanomaterials
respect
biological
systems
attracted
attention
in
recent
years.
This
review
presents
summary
nanoparticles,
mechanisms
by
which
effect
realized,
key
reported
methods
modifying
these
improve
their
activity.
A
comparative
analysis
effectiveness
presented
depending
type
microorganism,
shape
Gram
classification
bacteria
based
data
from
published
sources.
In
addition,
addresses
activities
including
antifungal
cytotoxic
well
“antioxidant”
According
conducted
literature
data,
it
can
be
concluded
that
significant
bacteriostatic
wide
microorganisms
and,
some
cases,
contribute
inhibition
fungal
growth.
At
same
sensitivity
Gram-positive
was
often
higher
than
Gram-negative
bacteria.
Plant Nano Biology,
Journal Year:
2024,
Volume and Issue:
7, P. 100065 - 100065
Published: Feb. 1, 2024
Of
late,
promptly
responding
materials
have
been
the
centre-stage
of
interdisciplinary
research.
Nanotechnology
has
emerged
as
a
blessing
herein,
enabling
atomic
scale
resolution
manifested
by
increasing
precision
structural,
surface
and
functionality
probing
characterizations.
Amongst
manifold
nanomaterials,
nanoparticles
(NPs)
transition
metals
swiftly
prominent
enhancing
entities,
attributed
to
quantum
confinement
(QC)
d
sub-shells
unpaired
electrons
encompassed
varied
oxidation
states.
Renewable
eco-friendly
methods
making
NPs
gathered
scientific
academic
attention
owing
their
steadfast
workability.
In
this
context,
plant
extracts
(PEs)
serve
green
reducing
agents
obtain
zerovalent
NMs
from
complex
metal
salts.
The
prepared
are
recognized
initially
via
QC
driven
distinct
optics
subsequently
through
explicit
structural
inspections.
encouraging
aspects
resources
herein
include
robust
availability
nature-friendly
working,
ruling
out
separate
addition
capping
agent.
Secondary
metabolites
comprise
backbone
PE,
them
even
more
befitting
for
biological
applications.
Realizing
this,
present
article
focuses
on
structure-function
regulated
chemistry
CuO
with
recent
advances
in
formation.
discussed
studies
post
2018
attempts
retrieved
"Pubmed"
using
keywords
"Bioactivities
Plant
Resources
Fabricated
Copper
Oxide
Nanoparticles".
sole
objective
is
understand
diverse
applications
vis-à-vis
modulated
constitutional
energy
levels
tuneable
semi-conducting
features.
discussion
could
strengthen
biomedical
an
environmental
utility
integrating
renewable
versatilities
sustainable
future.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(6), P. e27018 - e27018
Published: Feb. 28, 2024
Despite
the
success
of
antibiotics
in
medicine,
treatment
bacterial
infection
is
still
challenging
due
to
emerging
resistance
and
suitable
drug
delivery
system,
therefore,
innovative
approaches
focused
on
nanoparticles
based
antimicrobial
systems
are
highly
desired.
This
research
aimed
synthesize
Current Research in Biotechnology,
Journal Year:
2024,
Volume and Issue:
7, P. 100227 - 100227
Published: Jan. 1, 2024
Nanoscale
copper
oxide
(CuO
NPs)
with
diameters
in
the
80–150
nm
range
has
been
biosynthesized
using
lipopeptide
biosurfactant
derived
from
Bacillus
vallismortis
and
characterized
by
XRD
FE-SEM.
The
CuO
NPs
could
be
introduced
as
nanocarrier
systems
for
combination
therapy
a
potential
candidate
antibacterial,
antioxidant,
anticancer,
anti-diabetic
activity.
antibacterial
activity
of
was
studied
incorporating
nanoparticles
fluorescent
antibiotic
Ciprofloxacin
HCL
(CIP)
to
form
CIP@CuO
tracked
inside
HEK-293
cell
lines.
MIC
values
against
1
×
106
CFU
ml−1
Pseudomonas
aeruginosa
determined
76
µg
ml−1and
69
Staphylococcus
aureus.
were
conjugated
anticancer
drug
Doxorubicin
(DOX)
DOX@CuONPs,
improving
delivery
toward
cancer
(HeLa)
cells.
intracellular
uptake
drug-loaded
confirmed
confocal
micrographs.
Finally,
vitro
lipopeptide-coated
inhibitory
α-amylase.
In
contrast,
vivo
efficacy
validated
significant
reduction
blood
glucose
glutathione
levels.
positively
affected
histopathological
changes
pancreas
induced
diabetic
mice.
Cytotoxicity
testing
Zebrafish
demonstrated
abnormal
organ
development
varying
viability
hatching
rates
at
72
96
hpf,
an
LC50
45
µg/l.
Aside
various
medicinal
characteristics,
study
provided
valuable
information
on
cytotoxic
impact,
which
can
used
future
investigations
their
eco-toxicological
impacts.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(3), P. e25195 - e25195
Published: Jan. 30, 2024
Cuprous
oxide/copper/cupric
oxide
nanoparticles
were
synthesized
through
a
hybrid
process
involving
anodic
dissolution
and
controlled
redox
reaction
between
NaOH
glucose
in
the
solution.
The
study
demonstrates
structural
manipulation
of
material
by
varying
components
within
Morphology,
analyses
using
SEM
(Scanning
Electron
Microscope),
EDX
(Energy-dispersive
X-ray
spectroscopy),
TEM
(Transmission
FTIR
(Fourier
Transform
Infrared
Spectroscopy),
XRD
(X-ray
diffraction),
XPS
photoelectron
spectroscopy)
unveiled
tunability
material's
structure
based
on
components.
Nitrogen
adsorption
analysis
employing
Brunauer-Emmett-Teller
(BET)
equation
confirmed
porosity,
while
Dynamic
Light
Scattering
(DLS)
measurements
provided
insights
into
materials'
hydrodynamic
size
zeta
potential.
results
demonstrated
that
increasing
glucose/NaOH
ratio
during
reaction,
different
structures
morphologies
distinct
products
obtained
from
clustering
small
to
cubic
shape
flower-like
structure.
Antibacterial
activity
tests
conducted
various
bacterial
strains
showed
correlation
morphology
its
antibacterial
properties.
highest
substantial
efficacy
against
all
tested
at
dosage
100
μg/L
was
for
samples
with
morphology,
whereas
remaining
materials
no
discernible
effect
one
studied
bacteria.
also
sample
exhibited
superior
properties
when
dispersed
water
containing
dimethylsulfoxide.
Journal of Pharmacy And Bioallied Sciences,
Journal Year:
2024,
Volume and Issue:
16(Suppl 2), P. S1226 - S1232
Published: April 1, 2024
A
BSTRACT
Nonessential
heavy
metals
are
toxic
to
human
health.
In
this
study,
mercury,
a
hazardous
metal,
was
detected
by
colorimetric
analysis
using
Zingiber
(Z.)
officinale
.
The
eco-friendliness
of
method
also
emphasized.
ultraviolet
(UV)
spectrum
is
broad
peak
observed
at
200–250
nm
in
Z.
leaf
extracts.
UV
green
synthesized
exhibited
an
absorption
band
286
nm,
which
confirms
the
nanoparticle
(NP)
synthesis.
Fourier
transform
infrared
(FTIR)
vibrational
around
3307
cm−1
assigned
ν(O–H)
stretching
that
could
possibly
emanate
from
carbohydrates
or
phenolics.
peaks
found
2917
and
2849
ascribed
–C-H
stretch
alkyl
group,
1625
due
enolic
β-diketones
-C
=
O
carboxylic
acids,
while
corresponding
-C-O
1375
1029
cm−1.
assignment
similar.
It
clear
scanning
electron
microscope
(SEM)
image
constituent
parts
were
nonuniform,
sphere-shaped,
agglomerated,
average
size
30.9
nm.
X-ray
diffraction
(XRD)
used
determine
structural
characteristics
crystalline
nature
intensity
32.35°,
36.69°,
39.24°,
44.76°,
59.42°,
67.35°
are,
respectively,
2θ
values,
correspond
standard
database
values.
copper
NPs
tested
antibacterial
properties
against
various
strains
microorganisms,
including
Escherichia
coli:
25
μg/mL
2.01
±
0.11
100
5.37
0.12,
Staphylococcus
(S.)
aureus:
1.05
0.71
11.43
1.27,
Streptococcus
mutans:
02.01
0.1
15.67
0.17,
Enterococcus
faecalis
:
03.11
0.7
18.32
0.2.
short
novelty
lies
its
potential
relevance
health,
as
it
has
been
possess
bioactive
compounds
with
medicinal
properties,
such
antimicrobial,
antioxidant,
anti-inflammatory
activities,
making
promising
natural
resource
for
therapeutic
applications.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(2), P. 1323 - 1334
Published: Jan. 1, 2025
Water
pollution,
oxidative
stress
and
the
emergence
of
multidrug-resistant
bacterial
strains
are
significant
global
threats
that
require
urgent
attention
to
protect
human
health.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 10893 - 10893
Published: June 30, 2023
Copper
(Cu)-based
antimicrobial
compounds
(CBACs)
have
been
widely
used
to
control
phytopathogens
for
nearly
fourteen
decades.
Since
the
first
commercialized
Bordeaux
mixture
was
introduced,
CBACs
gradually
developed
from
highly
slightly
soluble
reagents
and
inorganic
synthetic
organic,
with
nanomaterials
being
a
recent
development.
Traditionally,
form
physical
film
on
surface
of
plant
tissues,
separating
micro-organisms
host,
then
release
divalent
or
monovalent
copper
ions
(Cu2+
Cu+)
construct
secondary
layer
protection
which
inhibits
growth
pathogens.
Recent
progress
has
demonstrated
that
low
concentration
Cu2+
may
elicit
immune
responses
in
plants.
This
supports
triple-tiered
role
CBACs:
break
contact,
inhibit
microorganisms,
stimulate
host
immunity.
spatial
defense
system,
is
integrated
both
inside
outside
cell,
provides
long-lasting
broad-spectrum
protection,
even
against
emergent
copper-resistant
strains.
Here,
we
review
findings
highlight
perspectives
underlying
mitigation
strategies
sustainable
utilization
CBACs.
