SYNERGISTIC BIOGENIC SYNTHESIS OF ZINC NANOPARTICLES BY PROBIOTICS SACCHAROMYCES CEREVISIAE AND LACTOBACILLUS FERMENTUM FOR FARM ANIMAL HEALTH AND NUTRITION DOI Creative Commons

Sudhair Abbas Bangash,

Sadia Sardar,

Qudsia Begum

et al.

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Probiotics, such as Lactobacillus fermentum and Saccharomyces cerevisiae, play a crucial role in catalyzing the biogenesis of nano-minerals, offering transformative solution to enhance nutrient absorption farm animals promote agricultural sustainability. This research aims synthesize ZnO nanoparticles using Probiotic assessing their antibacterial efficacy against MDR pathogens investigating impact Nano zinc supplementation on growth blood parameters goats. Utilizing analytical methods Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), ultraviolet–visible (UV–Vis), produced NPs were characterized, revealing distinct bonds structural features. nanoparticles, highlighted through FTIR (emphasizing N-H stretching at 1450-1500 cm-1 nanoparticle stretches 400-800 cm-1), SEM (revealing micro-sized bioconjugates with dimensions 100–120 nm), XRD (confirming hexagonal crystal structure approximately 36.50 degrees), demonstrated significant activity. Goats treated exhibited substantial weight gain over 12 weeks (Initial BW: 29.2±0.48 kg; Final Body Weight - Treatment C: 40.99±0.58 kg, ZnO-1: 43.39±0.45 ZnO-2: 44.05±0.43 kg), limited physiological effects, except for notable variations immunoglobulins (IgA, IgG) among treatment groups (p = 0.006 p 0.003, respectively). Notably, displayed activity (ZnO-1 E. cloacae: 13mm, A. baumannii: 12mm; ZnO-2 S. aureus: 12mm, P. aeruginosa: 12mm), indicating remarkable antimicrobial potency. environmentally friendly cost-effective approach synthesizing holds promise diverse biomedical applications.

Language: Английский

Expanding the Crystal Structure Landscape of Pravastatin Complexes: Tuning Solubility, Diffusion, and Pharmacokinetics DOI

Richu Bagya Varsa S,

Lasya Priya Katukam,

Goutam Kumar Kole

et al.

Crystal Growth & Design, Journal Year: 2024, Volume and Issue: 24(12), P. 5309 - 5323

Published: June 1, 2024

Pravastatin (PRV), a lipid-lowering medication, is prescribed to treat cardiovascular disease and dyslipidemia. Due its low permeability high solubility, the biopharmaceutics classification system (BCS) class III drug exhibits poor bioavailability. To overcome bottlenecks of PRV, novel complexes with Zn Cu along zwitterionic cocrystal l-proline (PRO) were synthesized. These new solid forms characterized by SC-XRD, PXRD, DSC, TGA, FT-IR, DVS, SEM images. Rietveld refinement was used obtain 3D coordinates PRV–Na–PRO ionic hydrate from high-resolution PXRD data. PRV–Cu obtained substituting PRV sodium salt Cu/Zn metal. In hydrate, each Na metal coordinated carboxylates (2) PRO (1) three water molecules result in an octahedron geometry. two carboxylate anions molecules, forming square pyramidal The PRV–Zn complex maintains octahedral geometry using four coordination molecules. exhibited higher solubility (1.7-fold) diffusion profile (1.1-fold) compared commercial PRV–Na whereas PRV–Cu/Zn showed controlled release. Surprisingly, enhanced peak plasma concentration Cmax (50 fold) AUC (14.4 during pharmacokinetics study rats. stability supported ground-state optimization energy calculations. Unlike moisture-sensitive PRV–Zn/Cu far superior moisture may offer extended On other hand, significantly improved bioavailability can be commercialized following proper formulation that offers stability.

Language: Английский

Citations

5
Crystals, Crystallization and X-ray Techniques: Pharmaceutical Application DOI
Kalyani Thombre,

Arpita Umap,

Krishna R. Gupta

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1906 - 1912

Published: April 12, 2025

Within pharmaceutical manufacturing, crystallization is one of the most extensively used and vital unit operation. Mass transfer a solute from liquid solution to pure solid known as crystallization, it chemical process solid-liquid separation. It result particles rapidly arranging themselves into regular geometric patterns or repetitive order. Because combines particle generating purification single process, beneficial isolation step for manufacturing. Nearly all products developed involving fine chemicals, such colors, explosives, photographic materials, need crystallize during manufacturing operations, over 90% contains bioactive medicinal product items excipients in crystalline form. Without acquiring supersaturation not achieve. There are many types equipment, which often on basis methods achieving suspending growing crystals. Probably important characteristics governing size, shape, hardness impurities. crystals because techniques involve drugs with improved physiochemical properties. A crucial variety uses crystallization. Purification, enhanced processing traits, physical stability, ease handling, prolonged release, separation entrapped constituents primary drivers

Language: Английский

Citations

0
Three Indomethacin cocrystals: preparation, characterization and formation thermodynamics DOI
Ying Zhang, Jingjing Liu,

Ling Yin

et al.

Process Safety and Environmental Protection, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
The Peculiar H-Bonding Network of 4-Methylcatechol: A Coupled Diffraction and In Silico Study DOI Creative Commons
Mattia Lopresti, Luca Palin,

Giovanni Calegari

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2173 - 2173

Published: May 7, 2024

The crystal structure of 4-methylcatechol (4MEC) has, to date, never been solved, despite its very simple chemical formula C7O2H8 and the many possible applications envisaged for this molecule. In work, gap is filled 4MEC obtained by combining X-ray powder diffraction first principle calculations carefully locate hydrogen atoms. Two molecules are present in asymmetric unit. Hirshfeld analysis confirmed reliability solved structure, since two show rather different environments H-bond interactions directionality strength. packing characterised a peculiar bond network with hydroxyl nests formed adjacent octagonal frameworks. It noteworthy that observed short contacts suggest strong inter-molecular interactions, further inter-crystalline aggregation microscopic images, indicating growth, crystallization attempts, single aggregates taller than half centimetre and, often, spherical shapes. These peculiarities induced presence methyl group 4MEC, parent compound catechol, similarity, shows standard layered alternating hydrophobic polar layers. Finally, complexity peculiarity growth features explain why could not be structural analysis.

Language: Английский

Citations

2
Pharmaceutical cocrystals: Unlocking the potential of challenging drug candidates DOI
Jidnyasa Pantwalawalkar, Niraj Kale, Sopan Nangare

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106572 - 106572

Published: Dec. 1, 2024

Language: Английский

Citations

2
PREPARATION, CHARACTERISATION, EVALUATION AND DFT ANALYSIS OF CILNIDIPINE-L-PHENYLALANINE COCRYSTAL DOI Open Access

Renjish Cherukkoth,

Sibi P. Ittiyavirah, Jyoti Harindran

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2023, Volume and Issue: unknown, P. 365 - 372

Published: Nov. 7, 2023

Objective: The objective of this study was to prepare, characterise and evaluate pharmaceutical cocrystals Cilnidipine using L-phenylalanine as the coformer enhance aqueous solubility Cilnidipine. It also proposed mechanism cocrystal formation based on Density Functional Theory (DFT) Gaussian software. Methods: To overcome limitation poor Cilnidipine, a 1:1 prepared by liquid assisted grinding (LAG) technique. resultant were characterised Fourier transform-infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) field emission electron microscopy (FE-SEM). They evaluated for their saturation in water. studied at DFT level theory. Results: band broadening the–NH and–NO peaks FTIR spectra indicated hydrogen bonds cocrystals. A single sharp melting endotherm 218.40 °C DSC curve confirmed appearance new PXRD pattern showed crystalline phase. FE-SEM analysis above findings. exhibited 3.31 folds enhancement solubility. intrmolecular bonding between the–NO and–NH L-phenylalanine. Conclusion: present demonstrated successful approach enhancing poorly water-soluble drug cocrystallisation technique coformer.

Language: Английский

Citations

1
Structural analysis of anti-retroviral drug raltegravir and its potential impurity C: investigation of solubility and stability DOI

T. K. S. Fayaz,

Hemanth Kumar Chanduluru,

Puja Lal

et al.

CrystEngComm, Journal Year: 2023, Volume and Issue: 26(4), P. 517 - 531

Published: Dec. 13, 2023

An anhydrous form of raltegravir and two crystalline phases its impurity C were obtained during solid screening their crystal structures are reported with variable conformations.

Language: Английский

Citations

1
Noncovalent Derivatization DOI
John C. Warner

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Citations

0
SYNERGISTIC BIOGENIC SYNTHESIS OF ZINC NANOPARTICLES BY PROBIOTICS SACCHAROMYCES CEREVISIAE AND LACTOBACILLUS FERMENTUM FOR FARM ANIMAL HEALTH AND NUTRITION DOI Creative Commons

Sudhair Abbas Bangash,

Sadia Sardar,

Qudsia Begum

et al.

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Probiotics, such as Lactobacillus fermentum and Saccharomyces cerevisiae, play a crucial role in catalyzing the biogenesis of nano-minerals, offering transformative solution to enhance nutrient absorption farm animals promote agricultural sustainability. This research aims synthesize ZnO nanoparticles using Probiotic assessing their antibacterial efficacy against MDR pathogens investigating impact Nano zinc supplementation on growth blood parameters goats. Utilizing analytical methods Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), ultraviolet–visible (UV–Vis), produced NPs were characterized, revealing distinct bonds structural features. nanoparticles, highlighted through FTIR (emphasizing N-H stretching at 1450-1500 cm-1 nanoparticle stretches 400-800 cm-1), SEM (revealing micro-sized bioconjugates with dimensions 100–120 nm), XRD (confirming hexagonal crystal structure approximately 36.50 degrees), demonstrated significant activity. Goats treated exhibited substantial weight gain over 12 weeks (Initial BW: 29.2±0.48 kg; Final Body Weight - Treatment C: 40.99±0.58 kg, ZnO-1: 43.39±0.45 ZnO-2: 44.05±0.43 kg), limited physiological effects, except for notable variations immunoglobulins (IgA, IgG) among treatment groups (p = 0.006 p 0.003, respectively). Notably, displayed activity (ZnO-1 E. cloacae: 13mm, A. baumannii: 12mm; ZnO-2 S. aureus: 12mm, P. aeruginosa: 12mm), indicating remarkable antimicrobial potency. environmentally friendly cost-effective approach synthesizing holds promise diverse biomedical applications.

Language: Английский

Citations

0