A comprehensive examination of mental health in patients with head and neck cancer: systematic review and meta-analysis

JNCI Cancer Spectrum, Journal Year: 2024, Volume and Issue: 8(3)

Published: April 30, 2024

Abstract Background Patients with head and neck cancer present particularly considerable levels of emotional distress. However, the actual rates clinically relevant mental health symptoms disorders among this population remain unknown. Methods A Preferred Reporting Items for Systematic Review Meta-Analyses Meta-analyses Observational Studies in Epidemiology–compliant systematic review quantitative random-effects meta-analysis was performed to determine suicide incidence prevalence depression, anxiety, distress, posttraumatic stress, insomnia population. MEDLINE, Web Science, Cochrane Central Register, KCI Korean Journal database, SciELO, Russian Science Citation Index, Ovid-PsycINFO databases were searched from database inception August 1, 2023 (PROSPERO: CRD42023441432). Subgroup analyses meta-regressions investigate effect clinical, therapeutical, methodological factors. Results total 208 studies (n = 654 413; median age 60.7 years; 25.5% women) identified. Among patients, 19.5% reported depressive (95% confidence interval [CI] 17% 21%), 17.8% anxiety CI 14% 34.3% distress 29% 39%), 17.7% 6% 41%), 43.8% 35% 52%). Diagnostic criteria assessments revealed lower disorders: 10.3% depression 7% 13%), 5.6% 2% 10%), 9.6% 1% 40%), stress 0% 84.5%). Suicide pooled 161.16 per 100 000 individuals year 82 239). Meta-regressions found a statistically significant higher patients undergoing primary chemoradiation compared surgery increased smokers advanced tumor staging. European samples exhibited Conclusions presented notable concerns all domains. remains highly concern. The criteria-meeting is significantly than symptoms. Investigating effectiveness targeted symptomatic essential.

Language: Английский

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Psychological Factors Related to Treatment Outcomes in Head and Neck Cancer

Advances in Therapy, Journal Year: 2024, Volume and Issue: 41(9), P. 3489 - 3519

Published: Aug. 7, 2024

Patients with head and neck cancer (HNC) often demonstrate stress, distress, anxiety, depression, are at risk for suicide. These affect their quality of life (QoL) but less attention has been given to psychological variables that may impact response treatment. This study aims systematically review publications during 2013–2023 collate evidence on the effects HNC treatment outcomes. We searched Ovid Medline, PubMed, Scopus, Web Science articles examined factors related outcomes in patients HNC. There were 29 studies (5 before treatment, 2 during, 17 after, 5 covering whole management trajectory) including 362,766 patients. The either behavioral (adjustment coping strategy, unrealistic ideas, self-blame), cognitive (elevated psychiatric co-comorbidity), or emotional (distress, nervousness, fear disfigurement complications). It was found there a relationship between depression decreased survival Pretreatment pain an independent predictor large sample distress level approximately 54%, problems ranged 10 44%, while financial difficulties identified 54% Sixty-nine percent reported have used least one cost-coping strategy within 6 months after initiation. During post-treatment period, increased from 15% baseline 29%, recurrence among 35% Several predict QoL survivors. Distress encompasses physical burden diagnosis Routine screening early interventions target could improve survivors' QoL. A systematic standardized measurement approach is warranted homogenize these findings understand underlying relationships.

Language: Английский

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Comorbid Depression in Patients With Head and Neck Cancer Compared With Other Cancers

JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Importance Depression is more prevalent among individuals with cancer than in the general population and correlated increased mortality patients head neck (HNC) particular. Objective To compare prevalence of depression between HNC other cancers. Design, Setting, Participants This retrospective cohort study used population-level data on aged 18 years or older who participated 2019 National Health Interview Survey had completed Personal Questionnaire-8 (PHQ-8). The analysis was performed August 7, 2023, April 5, 2024. Exposure Any diagnosis. Main Outcomes Measures main outcome severity based PHQ-8. magnitude difference baseline characteristics measured those types, 95% CIs were to measure precision these estimates. Multivariable logistic regressions evaluate association demographic, socioeconomic, anxiety, clinical variables depression. Results From a weighted 23 496 725 adult cancer, 377 080 diagnosed (87.5% 51-84 years; 77.9% male). any PHQ-8 (mild, moderate, severe) 40.1% vs 22.3% Compared cancers, equally likely screen positive for anxiety (23.6% 16.0%; difference, 7.6%; CI, −5.9% 21.1%), take medication (10.1% 13.9%; −3.8%; −11.9% 4.4%), state that they never feel depressed (59.7% 53.7%; 6.0%; −9.1% 21.0%). On multivariable regression analysis, having associated an likelihood (odds ratio [OR], 2.94; 1.39-6.22). Other factors being unmarried not living partner (OR, 1.94; 1.55-2.43) 23.14; 17.62-30.37). Conclusions Relevance found twice as validated survey despite similar rates self-reported use. These findings suggest self-reporting may result underreporting undertreatment this and, thus, need further work developing interventions improve identification optimize treatment comorbid

Language: Английский

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Depression and Distress Screening in Oncology Patients: A Descriptive Analysis

American Journal of Medical Quality, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

This retrospective study aimed to describe the characteristics of cancer patients undergoing depression and distress screening at Sidney Kimmel Cancer Center assess factors associated with their results. Data were retrieved from electronic medical records adult least one oncology encounter between January 2021 June 2022, who underwent both using Patient Health Questionnaire-2/9 for National Comprehensive Network thermometer during encounter. Demographics, clinical factors, results analyzed descriptive statistics binary logistic regression. A total 1954 screened psychological needs. Of these, 110 (5.6%) positive 830 (42.5%) distress. About 69.1% also Conversely, 9.2% depression. >65 years old found significantly less likely screen depression, while males African American be more than White (odds ratio: 2.58; confidence interval: 1:53–4.34). In this study, a higher proportion distressed depressed, suggesting that may useful tool in identifying psychosocial concerns population. Differences scores age, sex, race. These findings highlight need implementation effective strategies better address needs patients. Further research is warranted validate these impact on patient outcomes across various settings.

Language: Английский

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Cancer neuroscience in head and neck: interactions, modulation, and therapeutic strategies

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 31, 2025

Head and neck cancer (HNC) is an aggressive malignancy with significant effects on the innervation. Not only it at top of spectrum a dismal prognosis, but also imposes considerable stress patients society owing to frequent neurological symptoms. With progress in neuroscience, interactions between HNC nervous system, as well underlying mechanisms, have become increasingly clear. Compelling evidence suggests communication information nerve cells devastation system tumor growth. However, thorough grasp neuroscience has been severely constrained by intricacy fragmented research. This review comprehensively organizes summarizes latest research crosstalk system. It aims clarify various aspects HNC, including physiology, progression, treatment cancer. Furthermore, opportunities challenges are discussed, which offers fresh perspectives diagnosis management.

Language: Английский

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Anxiety symptoms predict head and neck cancer survival: Exploring mediation by systemic inflammation and tumor response to treatment

Psycho-Oncology, Journal Year: 2024, Volume and Issue: 33(7)

Published: July 1, 2024

Abstract Background Head and neck cancers (HNC) are associated with high rates of anxiety. Anxiety has been linked to biological pathways implicated in cancer progression, though little is known about its effects on overall survival. We hypothesized that higher pretreatment anxiety levels patients HNC would predict poorer 2‐year survival expected this relationship be mediated by both systemic inflammation tumor response treatment. Methods Patients ( N = 394) reported symptomatology via the GAD‐7 at treatment planning. Pre‐treatment hematology workup provided an index (SII; 292). Clinical data review yielded Logistic multiple regressions Cox proportional hazard models tested relationships. Results Higher were significantly (hazard ratio [HR], 1.039; 95% confidence interval [CI], 1.014–1.066, p 0.002). The association between SII was not significant, (odds [OR], 1.033; CI, 1.001–1.066, 0.043). Tumor fully symptoms (HR, 9.290, 6.152–14.031, < 0.001). Conclusions response, but inflammation, emerged as a potential pathway mediating effect. Screening for may beneficial help prospectively address these concerns ameliorate potentially detrimental impact clinically meaningful outcomes.

Language: Английский

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Metabolite Biomarkers of Prolonged and Intensified Pain and Distress in Head and Neck Cancer Patients Undergoing Radio- or Chemoradiotherapy by Means of NMR-Based Metabolomics—A Preliminary Study

Metabolites, Journal Year: 2024, Volume and Issue: 14(1), P. 60 - 60

Published: Jan. 17, 2024

Treatment of head and neck squamous cell carcinoma (HNSCC) has a detrimental impact on patient quality life. The rate recognized distress/depression among HNSCC patients ranges from 9.8% to 83.8%, the estimated prevalence depression receiving radiotherapy is 63%. Shorter overall survival also occurs in preexisting or depressive conditions. present study analyzes nuclear magnetic resonance (NMR) blood serum metabolic profiles during radio-/chemoradiotherapy correlates detected alterations with pain and/or distress accumulated disease its treatment. NMR spectra were acquired Bruker 400 MHz spectrometer analyzed using multivariate methods. results indicate that primarily affect lipids metabolites energy (glutamine, glucose, lactate, acetate) one-carbon (glycine, choline, betaine, methanol, threonine, serine, histidine, formate) metabolism. Sparse disturbances branched-chain amino acids (BCAA) involved protein metabolism (lysine, tyrosine, phenylalanine) are observed. Depending treatment modality—radiotherapy concurrent chemoradiotherapy—there some differences altered metabolites.

Language: Английский

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Psychosocial Distress Screening Among Interprofessional Palliative Care Teams: A Narrative Review

Journal of Social Work in End-of-Life & Palliative Care, Journal Year: 2024, Volume and Issue: 20(2), P. 161 - 184

Published: April 2, 2024

With increased need for palliative care and limited staffing resources, non-social workers are increasingly responsible screening urgent psychosocial distress. The National Consensus Project guidelines call all team members to be competent in across domains. Yet, contrast an abundance of evidence-informed tools social work assessments, standardization interprofessional is lacking. This lack standardized practice may lead harmful disparities delivery. purpose this narrative review examine current literature on practices within care. Google Scholar, a university Summon library search engine, prominent journals were searched using the same phrases locate articles inclusion. Each article was reviewed synthesized common themes. Although validated exists outpatient oncology-specific settings, there minimal guidance intended specialty most oft-cited have been met with concern validity diverse populations settings. Additional research needed operationalize measure brief that can use by teams, stepping-stone equity practice.

Language: Английский

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Patient-Reported Outcome Measures of Psychosocial Quality of Life in Oropharyngeal Cancer Patients: A Scoping Review

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(6), P. 2122 - 2122

Published: March 8, 2023

Background: Oropharyngeal squamous cell carcinoma (OPSCC) patients are burdened by the effect of disease process and treatment toxicities on organs important in everyday activities, such as breathing, speaking, eating, drinking. There is a rise OPSCC due to human papilloma virus (HPV)-associated OPSCC, affecting younger healthier with better overall prognosis. Emphasis must be shared between oncologic outcomes effects quality life. While there have been efforts study global physical life, impact psychosocial life has not yet specifically reviewed. Methods: A scoping review methodology was employed explore emotional, social, mental determine HPV status or modalities. Results: Eighty-seven full-text articles were evaluated for eligibility. Fifteen met final inclusion criteria. The majority studies conducted United States (n = 10) divided cross-sectional 6), prospective 5), retrospective 4). Four themes explored: health emotional wellbeing, social wellbeing function, stress, relationship sexual behavior. Eighteen different patient-reported outcome measures used, including both general head neck oncology questionnaires symptom-specific surveys. Conclusion: paucity research regarding patients’ Learning more about this component can guide outreach programs multidisciplinary involvement improving patient care.

Language: Английский

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Assessment of Health-Related Quality of Life and Distress in an Asian Community-Based Cancer Rehabilitation Program

Current Oncology, Journal Year: 2022, Volume and Issue: 29(10), P. 7012 - 7020

Published: Sept. 27, 2022

Cancer survivors have reduced health-related quality of life (HRQOL) and high levels distress during after active treatment, due to physical, psychological, social problems. Understanding the prevalence associations HRQOL in a patient population community is important when designing rehabilitation programs. This was cross-sectional observational study conducted at community-based cancer center, with aim investigating patients. There were 304 patients who recruited. We found low patients, mean FACT-G7 total score 11.68, thermometer 3.51. In multivariate regression model, significant factors for metastatic disease (p = 0.025) Malay ethnicity < 0.001). Regression analyses also that associated family health issues 0.003), depression 0.001), worry 0.005), breathing 0.007), getting around 0.012) indigestion 0.039). A impaired reported even setting. The physical psychosocial well-being should be monitored managed as part rehabilitation.

Language: Английский

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