Nutrients,
Journal Year:
2024,
Volume and Issue:
16(18), P. 3106 - 3106
Published: Sept. 14, 2024
(1)
The
main
aim
of
this
study
was
to
analyze
the
relationship
Mediterranean
diet
(MD)
with
vascular
function
in
participants
and
without
increased
insulin
resistance
(IR)
Spanish
population.
A
secondary
differences
by
gender.
(2)
Methods:
Data
were
analyzed
from
3401
subjects
EVA,
MARK,
EVIDENT
studies
(mean
age
=
60
years
57%
men).
IR
evaluated
triglyceride
glucose
index
(TyG
index).
TyG
Ln
[(fasting
mg/dL
×
fasting
mg/dL)/2].
MD
measured
against
MEDAS
questionnaire,
14
items
used
PREDIMED
study.
Vascular
stiffness
estimated
brachial–ankle
pulse
wave
velocity
(baPWV)
cardio
ankle
(CAVI)
using
Vasera
VS-1500®.
(3)
Results:
mean
value
5.82
±
2.03;
(men:
5.66
2.06;
women:
6.04
1.99;
p
<
0.001).
adherence
36.8%
34.2%;
40.3%;
baPWV
14.39
2.78;
14.50
2.65;
14.25
2.93;
0.005).
≥
14.5
m/s
found
43.4%
43.6%;
40.0%;
0.727).
CAVI
8.59
1.28;
8.75
8.37
1.26;
values
9
present
39.0%
44.4%;
31.7%;
TGC/G
10.93
1.39;
11.08
1.33;
10.73
1.43;
49.9%.
average
score
negatively
associated
all
groups
(<0.05),
except
group
women
resistance.
(4)
Conclusions:
results
suggest
that
is
parameters
studied
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 542 - 542
Published: Jan. 10, 2025
Diabetes
mellitus
(DM)
and
neurodegenerative
diseases/disturbances
are
worldwide
health
problems.
The
most
common
chronic
conditions
diagnosed
in
persons
60
years
older
type
2
diabetes
(T2DM)
cognitive
impairment.
It
was
found
that
is
a
major
risk
for
decline,
dementia,
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS)
other
disorders.
Different
mechanisms
of
associations
between
these
diseases
have
been
suggested.
For
example,
it
postulated
an
impaired
intracellular
insulin
signaling
pathway,
together
with
hyperglycemia
hyperinsulinemia,
may
cause
pathological
changes,
such
as
dysfunction
the
mitochondria,
oxidative
stress
inflammatory
responses,
etc.
association
diseases,
well
associations,
needs
further
investigation.
aim
this
review
to
describe
mellitus,
especially
1
(T1DM)
selected
i.e.,
disease,
sclerosis.
Suggested
also
described.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(4), P. 478 - 478
Published: April 8, 2024
Metformin
is
a
synthetic
biguanide
used
as
an
antidiabetic
drug
in
type
2
diabetes
mellitus,
achieved
by
studying
the
bioactive
metabolites
of
Galega
officinalis
L.
It
also
off-label
for
various
other
diseases,
such
subclinical
diabetes,
obesity,
polycystic
ovary
syndrome,
etc.
In
addition,
metformin
proposed
add-on
therapy
several
conditions,
including
autoimmune
neurodegenerative
and
cancer.
Although
has
been
many
decades,
it
still
subject
pharmacodynamic
pharmacokinetic
studies
light
its
extensive
use.
acts
at
mitochondrial
level
inhibiting
respiratory
chain,
thus
increasing
AMP/ATP
ratio
and,
subsequently,
activating
AMP-activated
protein
kinase.
However,
mechanisms
have
proposed,
binding
to
presenilin
enhancer
2,
GLP1
release,
modification
microRNA
expression.
Regarding
pharmacokinetics,
after
oral
administration,
absorbed,
distributed,
eliminated,
mainly
through
renal
route,
using
transporters
cationic
solutes,
since
exists
ionic
molecule
physiological
pH.
this
review,
particular
consideration
paid
literature
data
from
last
10
years,
deepening
study
clinical
trials
inherent
new
uses
metformin,
differences
effectiveness
safety
observed
between
sexes,
unwanted
side
effects.
For
objective,
was
evaluated
both
VigiBase
EudraVigilance,
respectively,
WHO
European
databases
reported
adverse
reactions,
assess
extent
effects
real-life
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7476 - 7476
Published: July 8, 2024
Cancer
is
one
of
the
major
causes
mortality
and
second
leading
cause
death.
Diabetes
mellitus
a
serious
growing
problem
worldwide,
its
prevalence
continues
to
grow;
it
12th
An
association
between
diabetes
cancer
has
been
suggested
for
more
than
100
years.
common
disease
diagnosed
among
patients
with
cancer,
evidence
indicates
that
approximately
8-18%
have
diabetes,
investigations
suggesting
an
some
particular
cancers,
increasing
risk
developing
cancers
such
as
pancreatic,
liver,
colon,
breast,
stomach,
few
others.
Breast
colorectal
increased
from
20%
30%
there
97%
intrahepatic
cholangiocarcinoma
or
endometrial
cancer.
On
other
hand,
number
therapies
increase
mellitus.
Complications
due
in
may
influence
choice
therapy.
Unfortunately,
mechanisms
associations
are
still
unknown.
The
aim
this
review
summarize
selected
update
on
underlying
association.
Medicina,
Journal Year:
2024,
Volume and Issue:
60(8), P. 1218 - 1218
Published: July 27, 2024
:
Cancer
is
a
multicausal
disease,
and
environmental,
cultural,
socioeconomic,
lifestyle,
genetic
factors
can
influence
the
risk
of
developing
cancer.
Colorectal
cancer
(CRC)
stands
as
third
most
common
globally.
Some
countries
have
observed
rise
in
incidence
CRC,
especially
among
young
people.
This
increase
associated
with
lifestyle
changes
over
last
few
decades,
including
diet
patterns,
sedentary
obesity.
Currently,
obesity
overweight
account
for
approximately
39%
world's
population
overall
mortality
certain
types.
study
aims
to
conduct
literature
review
examining
association
between
CRC.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8836 - 8836
Published: Aug. 14, 2024
Colorectal
cancer
(CRC)
affects
approximately
2
million
people
worldwide.
Obesity
is
the
major
risk
factor
for
CRC.
In
addition,
obesity
contributes
to
a
chronic
inflammatory
stage
that
enhances
tumor
progression
through
secretion
of
proinflammatory
cytokines.
addition
an
increased
response,
obesity-associated
presents
accrued
molecular
factors
related
characteristics,
such
as
genome
instability,
sustained
cell
proliferation,
telomere
dysfunctions,
angiogenesis,
and
microbial
alteration,
among
others.
Despite
evidence
accumulated
over
last
few
years,
treatments
CRC
do
not
differ
from
in
normal-weight
individuals.
this
review,
we
summarize
current
knowledge
on
cancer,
including
its
epidemiology,
factors,
treatments.
Finally,
enumerate
possible
new
therapeutic
targets
may
improve
conditions
obese
patients.
key
development
CRC,
resulting
reversal
should
be
considered
strategy
improving
antineoplastic
therapies.
BMC Endocrine Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 26, 2025
Insulin
resistance
(IR)
is
often
present
in
diabetes,
which
imposes
a
heavy
burden
on
the
prevention
and
treatment
of
diabetes.
Triglyceride
glucose
index
(TyG)
simple,
reliable
reproducible
detecting
IR,
has
great
advantages
predicting
risk
The
aim
this
study
was
to
analyze
potential
association
between
TyG
diabetes
Chinese
middle-aged
older
adults
using
prospective
cohort
design.
This
used
longitudinal
data
from
five
waves
China
Health
Retirement
Longitudinal
Study
(CHARLS)
conducted
2011,
2013,
2015,
2018,
2020,
involving
5886
participants.
We
Cox
proportional
regression
modeling
investigate
new-onset
decision
tree
analysis
identify
high-risk
groups
for
Finally,
ROC
curves
were
applied
order
construct
predictive
model
A
total
1054
(17.9%)
participants
developed
throughout
9-year
follow-up.
Our
utilized
multivariate
found
significant
correlation
risk.
also
revealed
nonlinear
relationship
risk.Receiver
Operating
Characteristic(ROC)
curve
showed
that
Area
under
curve(AUC)
area
0.652
(P
<
0.05).
can
be
as
factor
elderly
population
China.
In
addition,
there
Improving
insulin
by
regulating
lipid
metabolism
plays
an
important
role
primary
The European Research Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: Feb. 11, 2025
Objectives:
The
purpose
of
this
study
was
to
examine
the
function
prostate-specific
antigen
(PSA)
and
density
(PSAd)
in
screening
prostate
cancer
individuals
with
Diabetes
Mellitus
(DM).
Methods:
This
retrospective
cross-sectional.
467
patients
who
underwent
transrectal
ultrasound-guided
10-12
core
biopsy
between
01
January
31
December
2022
were
included.
Through
hospital
information
management
system,
demographics,
radiological,
biochemical,
pathological
results
scanned.
Results:
PSAd>0.15
ng/mL/cm³
total
PSA
(t-PSA)>8.58
ng/mL
substantially
associated
an
elevated
probability
existence
when
all
PSAd>0.19
t-PSA>11.34
shown
be
strongly
risk
DM
(P<0.001).
PSAd>0.14
t-PSA>8.49
presence
without
a
diagnosis
DM.
t-PSA>8.58
fasting
blood
glucose
(FBG)
<126
mg/dL
It
has
been
established
that
PSAd
cannot
utilized
as
marker
predict
people
FBG≥126
(P=0.070).
Higher
correlated
t-PSA
values
>5.73
(P=0.001).
Conclusions:
change
volume
brought
on
by
high
levels
might
cause
PSAd's
lack
selectivity.
Patients
are
special
group
screening,
should
considered
establishing
algorithms.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(4), P. 609 - 609
Published: Feb. 11, 2025
Background/Objectives:
The
incidence
and
mortality
of
early-onset
cancers
have
been
rising
in
recent
decades.
While
epidemiological
studies
examined
various
types
cancer,
updated
global
data
on
alcohol-attributable
primary
liver
cancer
(PLC)
young
adults
remains
limited.
Methods:
This
study
utilized
from
the
Global
Burden
Disease
(GBD)
spanning
2000
to
2021
evaluate
age-standardized
incidence,
mortality,
corresponding
rates
PLC
among
aged
15–49
years.
Results:
In
2021,
there
were
8290
cases
6590
deaths
adults.
rate
has
increased
Europe
(annual
percent
change
[APC]:
0.44%,
95%CI
0.35
0.54%),
Southeast
Asia
(APC:
0.40%,
95%
CI
0.37
0.44%),
Western
Pacific
region
0.65%,
0.44
0.86%).
represented
11%
(+2%
2000)
incident
all
About
half
countries
showed
an
increase
between
2021.
Conclusions:
shifted
significantly
over
past
two
decades,
with
notable
increases
Asia–Pacific
region.
trend
underscores
need
for
strategies
address
prevalence
alcohol
use
disorder
alcohol-associated
disease
their
impact
Scientia. Technology, science and society.,
Journal Year:
2025,
Volume and Issue:
2(3), P. 13 - 36
Published: March 1, 2025
Ultra-processed
foods
(UPFs)
are
defined
by
their
high
levels
of
refined
carbohydrates,
unhealthy
fats,
artificial
additives,
and
preservatives.
These
contribute
to
biological
aging
through
mechanisms
such
as
chronic
inflammation,
oxidative
stress,
metabolic
dysfunction.
Inflammation,
disruptions
in
insulin
signaling
key
factors
the
development
aging-related
diseases,
including
cardiovascular
disease,
diabetes,
neurodegenerative
disorders.
Specifically,
advanced
glycation
end-products
(AGEs)
epigenetic
modifications
significantly
acceleration
disrupting
cellular
function,
promoting
tissue
damage,
driving
disease
development.
UPF
consumption
is
linked
cancer,
gastrointestinal
disorders,
obstetric
gynecological
conditions,
a
range
adverse
effects
on
various
body
systems.
Reducing
intake
encouraging
healthier
dietary
patterns
crucial
for
mitigating
impact
UPFs
related
health
conditions.
For
individuals
unable
transition
whole
food-based
diets,
pharmaceutical
medical
interventions
offer
alternatives
reduce
UPF-related
aging.
A
combined
approach
pharmacologic
therapies
adjustments
may
optimize
outcomes,
with
ongoing
research
into
novel
treatments
further
enhancing
strategies
counteract
effects.
This
review
examines
accelerating
aging,
which
they
associated
potential
mitigate
