Ethnobotanical Insights Into the Bioactive Properties of Commercially Important Spice Seeds

Advances in bioinformatics and biomedical engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 123 - 190

Published: May 7, 2024

Ethnobotany provides key insights from ancient traditions, particularly focusing on spice seeds. Despite their growing commercial value in food and pharmaceuticals, there is still a need for thorough research into traditional uses scientifically validated properties. The objective of this chapter to compile integrate current ethnobotanical knowledge with recent scientific findings highlight the inherent medicinal pharmacological properties these plants. A comprehensive examination was conducted range applications, methods preparation, cultural significance plants have been described, latest confirmed therapeutic potential. In summary, numerous seeds are traditionally considered healing agents, modern has benefits. convergence advancements established foundation integration practices.

Language: Английский

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A Comprehensive Review of the Antioxidant, Antimicrobial, and Therapeutic Efficacies of Black Cumin (Nigella sativa L.) Seed Oil and Its Thymoquinone

Journal of Medicinal Food, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Black cumin (Nigella sativa L.) (family Ranunculaceae) is a largely utilized therapeutic herb worldwide. This comprehensive review discusses the pharmacological benefits of black seed oil, focusing on its bioactive component thymoquinone (TQ). The structured as follows: First, we examine antimicrobial properties followed by an analysis antioxidant capabilities. Finally, explore potential, particularly in neurodegenerative diseases and COVID-19. Phytochemicals from N. have exhibited potential for developing novel preventive strategies against jaundice, gastrointestinal disorders, skin diseases, anorexia, conjunctivitis, dyspepsia, intrinsic hemorrhage, amenorrhea, paralysis, rheumatism, diabetes, hypertension, fever, influenza, eczema, asthma, cough, bronchitis, headache. broader spectrum application essential bioactives certainly enhanced commercial value this oil. TQ, major constituent has numerous beneficial properties. Researchers extensively studied oil component, TQ. These studies revealed wide range properties, including anticancer, immunomodulatory, analgesic, antimicrobial, antidiabetic, anti-inflammatory effects. Additionally, TQ shown neuroprotective, spasmolytic, bronchodilatory, hepatoprotective, renoprotective, gastroprotective, activities.

Language: Английский

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Enhancement of Female Rat Fertility via Ethanolic Extract from Nigella sativa L. (Black Cumin) Seeds Assessed via HPLC-ESI-MS/MS and Molecular Docking

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 735 - 735

Published: Feb. 5, 2024

The characteristic chemical composition of Nigella seeds is directly linked to their beneficial properties. This study aimed investigate the phytochemical sativa using a 100% ethanolic extract HPLC-ESI-MS/MS. Additionally, it explored potential biological effects on female rat reproduction. Follicle Stimulating Hormone (FSH), Luteinizing (LH), Estrogen (E2), and Progesterone (P4) hormone levels were also assessed, along with morphological histological ovarian, oviductal, uterine tissues. Molecular docking was performed understand extract’s activity its role in regulating reproduction by assessing binding affinity hormonal receptors. Twenty metabolites, including alkaloids, saponins, terpenes, flavonoids, phenolic acids, fatty found N. through HPLC-ESI-MS/MS study. seed exhibited strong estrogenic LH-like activities (p < 0.05) weak FSH-like activity. Furthermore, increased serum LH 0.05), P4 hormones 0.001), E2 0.0001). results displayed interaction Erβ, LH, GnRH, receptors, respectively. Based these findings, demonstrated hormone-like activities, suggesting as treatment for improving fertility.

Language: Английский

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Insights into the antioxidant, anti-inflammatory and anti-microbial potential of Nigella sativa essential oil against oral pathogens

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 24, 2024

Oral disorders can exert systemic ramifications beyond their localized effects on dental tissues, implicating a wide array of physiological conditions. The utilization essential oils (EOs) for protection oral health represents longstanding practice. Consequently, in this investigation, oil derived from Nigella sativa seeds (NSEO) underwent isolation via the hydro-distillation process, followed by comprehensive evaluation its antioxidant, anti-inflammatory, anti-fungal, antibacterial activities, and cytocompatibility. isolated NSEO manifested as pale-yellow substance was found to harbor diverse spectrum bioactive constituents, including steroids, triterpenoids, flavonoids, phenols, proteins, alkaloids, tannin, sesquiterpenoid hydrocarbons, monoterpenoid alcohol, ketone (thymoquinone). Notably, total phenolic content (TPC) flavonoid (TFC) were quantified at 641.23 μg GAE/gm 442.25 QE/g, respectively. Furthermore, exhibited concentration-dependent inhibition protein denaturation, HRBC membrane stabilization, hemolysis inhibition. Comparative analysis revealed that chlorhexidine (CHX) 0.2% displayed substantial compared aspirin. While CHX demonstrated analogous activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, showcased heightened efficacy Lactobacillus acidophilus Candida albicans. Additionally, pronounced periodontal pathogens such Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia. Importantly, no cytotoxicity observed human gingival fibroblast cell lines. These findings underscore potential potent antifungal agent management microbial pathogens, thereby offering avenues development innovative therapies targeting inflammatory Nevertheless, further investigations are imperative unlock full therapeutic repertoire.

Language: Английский

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Effects of ceftriaxone, black seed oil (Nigella sativa), and their combination on interleukin-10 expression in a Wistar rat peritonitis model

Chirurgia, Journal Year: 2025, Volume and Issue: 38(1)

Published: Feb. 1, 2025

Language: Английский

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Role and mechanism of herbal bioactives in treatment of Parkinson disease: A promising therapeutic approach

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 181, P. 315 - 338

Published: April 25, 2025

Language: Английский

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An investigation into the usage of black cumin derivatives against cancer and COVID-19 as the nature medicine

Journal of Biomolecular Structure and Dynamics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Jan. 10, 2024

Black cumin has been used as a spice and food preservative for years. Thymol, thymoquinone, thymohydroquinone dihydrothymoquinone are the most important natural agents in black cumin. In order to determine active compound theoretical calculations have carried out different phases by using density functional theory (DFT). The inhibition effect of derivatives on Histone deacetylase 2 (HDAC2) determined supported experimental studies without losing time matter. chemical activity, stability solubility substances theoretically calculated. compounds had investigated seeds when extracted with water. Their polarity blood water parameters. HDAC2- interaction investigated. It that found very effective protecting ACE2 against COVID-19 comparing docking results receptors selected ligands COVID-19.

Language: Английский

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Black Seed Oil-Based Curcumin Nanoformulations Ameliorated Cuprizone-Induced Demyelination in the Mouse Hippocampus

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Language: Английский

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Ameliorative Effects of Cumin Extract-Encapsulated Chitosan Nanoparticles on Skeletal Muscle Atrophy and Grip Strength in Streptozotocin-Induced Diabetic Rats

Antioxidants, Journal Year: 2023, Volume and Issue: 13(1), P. 6 - 6

Published: Dec. 19, 2023

Skeletal muscle atrophy is a disorder characterized by reductions in size and strength. Cumin extract (CE) possesses anti-inflammatory, antioxidant, hypoglycemic properties. Its pharmaceutical applications are hindered its low water solubility cytotoxicity when administered at high doses. In this study, we have developed simplified distillation method using rotary evaporator to isolate the active components cumin seeds. The anti-inflammatory effects of CE potential ameliorate skeletal rats with streptozotocin (STZ)-induced diabetes were evaluated. half-maximal inhibitory concentration (IC50) for cells was 80 μM. By encapsulating chitosan nanoparticles (CECNs), an encapsulation efficacy 87.1% achieved slow release 90% after 24 h culturing, resulting CECNs significantly reduced (IC50, 1.2 mM). Both inflammatory response interleukin (IL)-6 IL-1β assays. STZ-induced diabetic exhibited sustained blood glucose levels (>16.5 mmol/L), small damaged pancreatic β islets, atrophy. CECN treatments ameliorated atrophy, recovered fiber striated appearance, increased grip strength, decreased IL-6 level. Furthermore, led reduction damage pancreas, restoring morphological phenotype, increasing serum insulin levels, lowering rats. Taken together, treatment over 6-week period yielded positive ameliorative

Language: Английский

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ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME

Ankara Universitesi Eczacilik Fakultesi Dergisi, Journal Year: 2024, Volume and Issue: 48(2), P. 2 - 2

Published: Feb. 18, 2024

Amaç: Enflamatuar bağırsak hastalığı (EBH), ülserasyon, kanama, sıvı ve elektrolit kaybı ile karakterize, atak remisyon dönemlerinden oluşan gastrointestinal sistemin (GİS) kronik enflamasyonudur. Ülseratif kolit Chron, etiyolojisi patogenezi tam olarak belli olmayan EBH’nin majör klinik formlarıdır. Son yıllarda ülkemizde dünyada insidansı prevalansı gittikçe artan EBH, bireylerin yaşam kalitesini olumsuz etkilemektedir. Bu durum hastalığın tedavisini daha da önemli hale getirmektedir. Fakat bu tedavi yöntemleri süresinin uzatılması progresyonunun önlenmesi için yetersiz kalabilmektedir. nedenle hastalar esas tedavilerine ek farklı tamamlayıcı arayışlarına yönelmektedir. yöntemler arasında hastaların en sık başvurduğu tedavi, bitkisel ürünlerdir. Sonuç Tartışma: Bitkisel ürünlerin kullanımı, hastalık üzerinde olumlu etkiler yapabildiği gibi etkilere de yol açabilmektedir. standartlara sahip uygun hastalıkta, formda, dozda hekim/eczacı kontrolünde kullanılması gerekmektedir. Literatürdeki çalışmalar değerlendirildiğinde; enflamatuar hastalıklarında kullanılan tıbbi bitkilerin fazlalığına rağmen birçoğunun potansiyel etki mekanizmasının olumlu/olumsuz etkilerinin ortaya konmadığı görülmektedir. yanlış bilinçsizce kullanımı seyrinin kötüleşmesine açabileceğinden bitkilerle ilgili fazla araştırmaya ihtiyaç duyulmaktadır.

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