Polymers,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1567 - 1567
Published: June 1, 2024
PETG
(poly(ethylene
glycol-co-cyclohexane-1,4-dimethanol
terephthalate))
is
an
amorphous
copolymer,
biocompatible,
recyclable,
and
versatile.
Nowadays,
it
being
actively
researched
for
biomedical
applications.
However,
proposals
of
as
a
platform
the
loading
bioactive
compounds
from
natural
extract
are
scarce,
well
effect
supercritical
impregnation
on
this
polymer.
In
work,
filaments
with
Olea
europaea
leaf
was
investigated,
evaluating
pressure
(100–400
bar),
temperature
(35–55
°C),
depressurization
rate
(5–50
bar
min−1)
expansion
degree,
antioxidant
activity,
mechanical
properties
resulting
filaments.
degree
ranged
~3
to
120%,
ranging
2.28
17.96
g
per
100
polymer,
corresponding
oxidation
inhibition
values
7.65
66.55%,
respectively.
The
binary
interaction
between
most
affected
these
properties.
depended
greatly
process
variables.
Tensile
strength
were
similar
or
lower
than
untreated
Young’s
modulus
elongation
at
break
decreased
below
~1000
MPa
~10%,
respectively,
after
scCO2
treatment
impregnation.
extent
decrease
operational
parameters.
Therefore,
higher
activity
different
degrees
obtained
by
adjusting
processing
conditions.
Frontiers in Drug Discovery,
Journal Year:
2024,
Volume and Issue:
4
Published: Aug. 20, 2024
Traditional
de
novo
drug
discovery,
which
typically
presents
an
11%
approval
rate
from
phase
I
trials
and
even
higher
failure
rates
in
fields
like
neurodegeneration,
often
requires
two
to
three
billion
dollars
10–17
years
per
new
drug.
In
contrast,
repurposing
can
reduce
risks
bring
drugs
the
market
3–12
years,
with
average
of
$300
million
investment.
this
article,
we
will
outline
how
accelerate
discovery
derived
natural
synthetic
products.
The
vast
amount
chemical,
biological,
structural,
clinical
data
available
public
repositories
greatly
facilitate
without
need
start
a
campaign
scratch.
big
era,
mining
artificial
intelligence
play
major
roles
both
discovery.
This
article
provide
valuable
insights
into
support
vice
versa
,
emphasizing
its
impact
addressing
unmet
medical
needs,
achieving
cost-effectiveness,
enabling
faster
access.
Despite
legal
regulatory
challenges,
potential
give
life
compounds
already
pipeline
make
crucial
complement
traditional
era
precision
medicine.
International Immunopharmacology,
Journal Year:
2025,
Volume and Issue:
147, P. 113979 - 113979
Published: Jan. 1, 2025
This
review
explores
the
progressive
domain
of
network
pharmacology
and
its
potential
to
revolutionize
therapeutic
approaches
for
Interstitial
Lung
Diseases
(ILDs),
a
collective
term
encompassing
Pneumonia,
Pneumoconiosis,
Connective
Tissue
Disease-related
ILDs,
Sarcoidosis.
The
exploration
focuses
on
profound
legacy
traditional
medicines,
particularly
Ayurveda
Traditional
Chinese
Medicines
(TCM),
their
largely
unexplored
capacity
in
ILD
treatment.
These
ancient
healing
systems,
characterized
by
holistic
methodologies
multifaceted
treatment
modalities,
offer
promising
foundation
discovering
innovative
strategies.
Moreover,
underscores
amalgamation
artificial
intelligence
(AI)
machine
learning
(ML)
with
bioinformatics,
creating
computational
synergy
capable
deciphering
intricate
biological
networks
associated
ILDs.
Network
has
tailored
hypothesis
from
conventional
"one
target,
one
drug"
towards
"network
multi-component
therapeutics"
approach.
fusion
literature
technology
can
unveil
novel
drugs,
targets,
pathways,
augmenting
effective
therapies
diminishing
adverse
effects
related
current
medications.
In
conclusion,
this
provides
comprehensive
exposition
how
Pharmacology
tools
leverage
insights
TCM
craft
efficacious
solutions
It
sets
stage
future
investigations
captivating
interdisciplinary
domain,
validating
use
medicines
worldwide.
Drugs and Drug Candidates,
Journal Year:
2025,
Volume and Issue:
4(1), P. 4 - 4
Published: Feb. 5, 2025
Background/Objectives:
The
interaction
of
bioactive
compounds
derived
from
plants
with
drugs
has
become
a
significant
area
investigation
due
to
its
potential
improve,
reduce,
or
have
no
effect
on
therapeutic
outcomes.
Due
the
dual
these
interactions,
elucidating
underlying
mechanisms
is
essential
for
establishing
strategy.
This
study
emphasizes
findings,
mechanisms,
and
clinical
implications
drug–plant
interactions.
It
calls
more
studies
seek
safe
effective
incorporation
into
practice.
Methods:
To
identify
relevant
studies,
we
performed
systematic
literature
search
based
various
scientific
databases
11
August
2024
30
December
2024.
will
be
keywords
such
as
synergy,
antagonism,
plant
compounds,
drug
interactions
supplemented
secondary
terms
phytochemicals,
herb-drug
pharmacokinetics,
pharmacodynamics.
Results:
Plant
bioactives,
including
polyphenols,
flavonoids,
alkaloids,
terpenoids,
display
valuable
biological
activities
that
can
interact
medications
in
three
principal
ways:
additive
effects,
antagonism.
Synergy
occurs
when
combined
effects
chemicals
pharmaceuticals
outweigh
sum
their
separate
increasing
effectiveness
allowing
dosage
decrease
reduce
adverse
effects.
Additive
occur
impact
equals
total
individual
resulting
better
outcomes
without
risk.
Antagonism
ingredient
reduces
counteracts
medicine,
thereby
jeopardizing
treatment.
In
addition,
specific
may
discernible
effect.
chemical
makeup
chemicals,
medication
patient
characteristics
genetics
metabolism
all
intricacy
Conclusions:
Pharmacokinetics
pharmacodynamics
considerably
modulated
through
components,
which
cause
efficacy
increase
toxicity
agents.
More
are
needed
clarify
action,
prove
relevance,
create
guidelines
co-administration.
integrative
approach
mitigate
those
risks
allow
optimization
by
introducing
pharmacogenomics
personalized
medicine
approaches.
Biology,
Journal Year:
2024,
Volume and Issue:
13(7), P. 506 - 506
Published: July 7, 2024
Traditional
natural
products
have
been
the
focus
of
research
to
explore
their
medicinal
properties.
One
such
medicinally
important
plant
is
white
mulberry,
