NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality DOI Creative Commons

Pauline Tarot,

Christelle Lasbleiz,

Jean-Charles Liévens

et al.

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(5), P. 1006 - 1012

Published: Sept. 22, 2023

Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons. Symptoms include muscle weakness and atrophy, spasticity, progressive paralysis. Currently, there no treatment reverse damage neurons cure amyotrophic sclerosis. The only two treatments actually approved, riluzole edaravone, have shown mitigated beneficial effects. difficulty find lies in complexity multifaceted pattern pathogenesis. Among mechanisms, abnormal RNA metabolism, nucleocytoplasmic transport defects, accumulation unfolded protein, mitochondrial dysfunction would fine induce oxidative vice versa. A potent therapeutic strategy will be molecules that break this vicious circle. Sharpening nuclear factor erythroid-2 related 2 signaling may fulfill objective since has multitarget profile controlling antioxidant defense, functioning, inflammation. We here discuss interest developing 2-based therapy regard pathophysiological mechanisms we provide general overview attempted clinical assays

Language: Английский

Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols DOI Creative Commons

Annamaria Russo,

Stefano Putaggio,

Ester Tellone

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1211 - 1211

Published: March 8, 2025

Neurodegenerative diseases are a group of that share common features, such as the generation misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entirely clear, complex neurodegenerative disease linked both to gene mutations affecting different proteins, superoxide dismutase 1, Tar DNA binding 43, Chromosome 9 open frame 72, Fused in Sarcoma, altered iron homeostasis, mitochondrial dysfunction, stress, impaired glutamate metabolism. The purpose this review highlight molecular targets ALS ferroptosis. Indeed, many pathways implicated hallmarks ferroptosis, recently discovered type iron-dependent programmed cell death characterized by reactive oxygen species (ROS) lipid peroxidation. Iron accumulation results dysfunction levels ROS, peroxidation, ferroptosis triggers; addition, inhibition Xc− system reduced cystine accumulation, leading excitotoxicity GPx4 synthesis. These potential involvement ALS, providing new biochemical could be exploited treatment using polyphenols.

Language: Английский

Citations

0
Nutritional Interventions in Amyotrophic Lateral Sclerosis: From Ketogenic Diet and Neuroprotective Nutrients to the Microbiota-Gut-Brain Axis Regulation DOI

Samira Nabakhteh,

Amir Lotfi,

Arman Afsartaha

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
Autonomic nervous system and mediating role of respiratory function in patients with ALS DOI Creative Commons
N. Bernardo, José Enrique de la Rubia Ortí, Carlos Villarón-Casales

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 27, 2025

Abstract Patients with Amyotrophic Lateral Sclerosis (ALS) exhibit altered patterns of respiratory rate and heart rhythm that are directly related to autonomic nervous system (ANS) activity. This study aimed analyze the role ANS in function, cognition, functionality, antioxidant capacity patients ALS through a predictive model assesses mediating activity respiration. quantitative, observational, analytical, cross-sectional clinical was conducted using sample 75 diagnosed ALS. activity, were also measured. Using these values, structural equation developed AMOS V.23 software. The mediational showed increased sympathetic (SNS) turn, whereas parasympathetic respiration very weak had opposite effect. Furthermore, SNS function which, improved functional capacity, power ALS, playing role. effect observed primarily between disability. For oxidative stress, high effect, such greater corresponded capacity. Additionally, for cognitive moderate direct observed; however, it greatly enhanced by Finally, differences only found based on sex, being higher men.

Language: Английский

Citations

0
Exploring Oxidative Stress in Disease and Its Connection with Adenosine DOI Creative Commons
Ana Salomé Correia, Nuno Vale

Oxygen, Journal Year: 2024, Volume and Issue: 4(3), P. 325 - 337

Published: Aug. 19, 2024

Oxidative stress, characterized by an imbalance between the production of reactive oxygen species and body’s antioxidant defenses, plays important role in pathogenesis various health conditions, including cancer neurological disorders. For example, excessive ROS can lead to mutations, genomic instability, uncontrolled cell proliferation cancer. In disorders, oxidative stress contributes neuronal damage, inflammation, progression diseases such as Alzheimer’s Parkinson’s diseases. Adenosine, a nucleoside involved energy transfer signal transduction, is crucial maintaining cellular homeostasis. Its extends modulating stress. Adenosine receptors are implicated physiological processes pathophysiology The interplay adenosine signaling complex critical. modulate responses, providing therapeutic potential for conditions where key player. Understanding this connection opens up avenues novel strategies targeting mitigate damage.

Language: Английский

Citations

3
Synthesis, characterization, in-silico, and pharmacological evaluation of new 2-amino-6‑trifluoromethoxy benzothiazole derivatives DOI
Sumra Malik,

G.A Miana,

Athar Ata

et al.

Bioorganic Chemistry, Journal Year: 2022, Volume and Issue: 130, P. 106175 - 106175

Published: Oct. 21, 2022

Language: Английский

Citations

13
Amyotrophic Lateral Sclerosis: A Diet Review DOI Creative Commons
Salvatore D’Antona, Martina Caramenti, Danilo Porro

et al.

Foods, Journal Year: 2021, Volume and Issue: 10(12), P. 3128 - 3128

Published: Dec. 17, 2021

Amyotrophic lateral sclerosis (ALS) is a fatal disease related to upper and lower motor neurons degeneration. Although the environmental genetic causes of this are still unclear, some factors involved in ALS onset such as oxidative stress may be influenced by diet. A higher risk has been correlated with high fat glutamate intake β-methylamino-L-alanine. On contrary, diet based on antioxidant anti-inflammatory compounds, curcumin, creatine, coenzyme Q10, vitamin E, A, C, phytochemicals could reduce ALS. However, data controversial there discrepancy among different studies due limited number samples many variables that involved. In addition, an improper lead altered microbiota consequently metabolism predispose onset. review we summarized research involve aspects epidemiology, diet, eating behaviour, microbiota, metabolic diseases. Further needed better comprehend role diseases mechanisms leading progression.

Language: Английский

Citations

15
Activation of the Nrf2 Pathway as a Therapeutic Strategy for ALS Treatment DOI Creative Commons

Liaisan Arslanbaeva,

Marco Bisaglia

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1471 - 1471

Published: Feb. 22, 2022

Amyotrophic lateral sclerosis is a progressive and fatal disease that causes motoneurons degeneration functional impairment of voluntary muscles, with limited poorly efficient therapies. Alterations in the Nrf2-ARE pathway are associated ALS pathology result aberrant oxidative stress, making stimulation Nrf2-mediated antioxidant response promising therapeutic strategy to reduce stress. In this review, we first introduce involvement Nrf2 pathogenesis role played by astrocytes modulating such protective pathway. We then describe currently developed activators Nrf2, used both preclinical animal models clinical studies, taking into consideration their potentialities as well possible limitations use.

Language: Английский

Citations

11
Statins and hearing DOI Creative Commons

Donna S. Whitlon

Hearing Research, Journal Year: 2022, Volume and Issue: 425, P. 108453 - 108453

Published: Jan. 31, 2022

Language: Английский

Citations

9
Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders DOI Open Access
Annia Galano, Eduardo Gabriel Guzmán‐López, Rüssel J. Reiter

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11584 - 11584

Published: Oct. 27, 2021

Although melatonin is an astonishing molecule, it possible that chemistry will help in the discovery of new compounds derived from may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes significant amount data gathered to date multiple health benefits related compounds. also highlights some most recent directions multifunctional pharmaceuticals intended act as one-molecule multiple-target drugs with potential use multifactorial diseases, including neurodegenerative disorders. Herein, we discuss beneficial activities derivatives reported date, addition computational strategies rationally design by functionalization molecular framework. It hoped this promote more investigations on subject both experimental theoretical perspectives.

Language: Английский

Citations

11
Synthesis of conjugates of 5-methyl-2-phenylpyrazol-3-ones and 1-aminoadamantanes as potential neuroprotective agents DOI
А. Yu. Aksinenko,

Т. В. Горева,

Т. А. Епишина

et al.

Russian Chemical Bulletin, Journal Year: 2022, Volume and Issue: 71(8), P. 1794 - 1800

Published: Aug. 1, 2022

Language: Английский

Citations

8