Gut microbiome encoded purine and amino acid pathways present prospective biomarkers for predicting metformin therapy efficacy in newly diagnosed T2D patients DOI Creative Commons
Ilze Elbere, Zigmunds Orlovskis, Laura Ansone

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 13, 2024

Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy highly variable within human population. Understanding potential indirect or synergistic effects on gut microbiota composition and encoded functions could potentially offer new insights into predicting treatment designing more personalized treatments in future. We combined targeted metabolomics metagenomic profiling microbiomes newly diagnosed T2D patients before after therapy to identify pre-treatment biomarkers functional signatures induced changes responders. Our sequencing data were largely corroborated by our metabolic identified that enrichment microbial encoding purine degradation glutamate biosynthesis was associated with good response. Furthermore, we glutamine-associated amino acid (arginine, ornithine, putrescine) metabolism characterize differences therapy. Moreover, Responders' displayed a shifted balance between bacterial lipidA synthesis as well alterations glutamate-dependent N-acetyl-galactosamine its derivatives (e.g. CMP-pseudaminate) which suggest modulation cell walls barrier, thus mediating microbiome composition. Together, glutamine products may condition activity via multiple therefore serve important efficacy.

Language: Английский

Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation DOI
Rongrong Wu, Rui Xiong,

Yan Li

et al.

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103062 - 103062

Published: May 27, 2023

Language: Английский

Citations

69
Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases DOI Open Access
Mohamed Kamel,

Sami Aleya,

Majed Alsubih

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Language: Английский

Citations

23
Dysbiosis of Gut Microbiota from the Perspective of the Gut–Brain Axis: Role in the Provocation of Neurological Disorders DOI Creative Commons
Meenakshi Kandpal, Omkar Indari, Budhadev Baral

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 12(11), P. 1064 - 1064

Published: Nov. 3, 2022

The gut-brain axis is a bidirectional communication network connecting the gastrointestinal tract and central nervous system. keeps track of activities integrates them to connect gut health higher cognitive parts brain. Disruption in this connection may facilitate various neurological problems. Neurodegenerative diseases are characterized by progressive dysfunction specific populations neurons, determining clinical presentation. Misfolded protein aggregates that cause cellular toxicity aid collapse proteostasis defining characteristic neurodegenerative proteinopathies. These disorders not only caused changes neural compartment but also due other factors non-neural origin. Mounting data reveal majority (GI) physiologies mechanics governed system (CNS). Furthermore, microbiota plays critical role regulation physiological function brain, although mechanism involved has yet been fully interpreted. One emerging explanations start progression many illnesses dysbiosis microbial makeup. present understanding literature surrounding relationship between intestinal emergence certain diseases, such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis, main emphasis review. potential entry pathway pathogen-associated secretions toxins into CNS explored article at outset neuropathology. We have included possible undelaying synergistic effect infections, their metabolites, interactions based on current understanding.

Language: Английский

Citations

69
Plant mediated-green synthesis of zinc oxide nanoparticles: An insight into biomedical applications DOI Creative Commons
Rania Hamed,

Ruwa Z. Obeid,

Rana Abu‐Huwaij

et al.

Nanotechnology Reviews, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 1, 2023

Abstract Green synthesis of zinc oxide (ZnO) nanoparticles (NPs) using various plant extracts as reducing and capping agents has gained attention in recent research. The green ZnO NPs offers several advantages such being simple, eco-friendly, safe, cost-effective, reproducible approach with high stability. Hence, this article provides an overview metal compounds, traditional chemical physical primary focuses on the NPs. This study discusses used proposed mechanisms Additionally, it explores cytotoxic green-synthesized addresses biomedical applications NPs, including antibacterial, anticancer, antidiabetic, antioxidant, antifungal, antiviral, antiparasitic, anti-inflammatory, wound healing. Moreover, review critically toxicity emphasizes need for more toxicological studies to ensure safety facilitate risk assessments management Furthermore, underlines challenges associated translation process from bench market, complex time-consuming regulatory approval which requires a multidisciplinary involving scientists, regulators, manufacturers.

Language: Английский

Citations

38
Difficulties in Adaptation of the Mother and Newborn via Cesarean Section versus Natural Birth—A Narrative Review DOI Creative Commons
Vasile Valeriu Lupu, Ingrith Miron, Anca Adam Răileanu

et al.

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 300 - 300

Published: Jan. 21, 2023

Birth is a physiological act that part of the morpho-functional economy maternal body. Each stage in birth has predetermined pathway neurohormonally induced and morpho-functionally established through specific characteristic adaptations. Like maternity, childbirth also an important impact on body as biological structure psycho-emotional behavior. Cesarean section performed at request mother with no medical underlying conditions besides prolonged hospitalization risk can cause breathing problems children, delayed breastfeeding, possible complications future pregnancy. Vaginal remains path choice for evolution Although erroneously considered safe easy today, cesarean delivery must remain emergency procedure or recommended pregnancies where to child, itself factor negative outcomes both baby. This review summarizes natural have newborn their attempt adapt postpartum events extrauterine life.

Language: Английский

Citations

31
Unveiling the therapeutic potential of exogenous β-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis DOI Creative Commons
Rasha Abdelhady, Sameh Saber, Mustafa Ahmed Abdel‐Reheim

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 28, 2023

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal area that demonstrates dramatically increasing incidence worldwide. This study provides novel insights into capacity exogenous β-hydroxybutyrate and ketogenic diet (KD) consumption to alleviate dextran sodium sulfate (DSS)-induced UC in rats. Remarkably, both interventions attenuated activity colon weight-to-length ratio, improved macro microstructures damaged colon. Importantly, KD curbed DSS-induced aberrant NLRP3 inflammasome activation as observed mRNA protein expression analysis. Additionally, inhibition NLRP3/NGSDMD-mediated pyroptosis was detected response regimens. In parallel, these modalities caspase-1 its associated consequences IL-1β IL-18 overproduction. They also mitigated apoptosis indicated by inactivation caspase-3. The anti-inflammatory effects BHB were confirmed reported decline levels markers including MPO, NFκB, IL-6, TNF-α. Moreover, exhibited antioxidative properties reducing ROS production improving enzymes. Their effectiveness mitigating evident renovation normal intestinal epithelial barrier function, shown correcting discrepancies tight junction proteins ZO-1, OCLN, CLDN5. Furthermore, their on microbiota homeostasis investigated. terms autophagy, upregulated BECN-1 downregulated p62, which may account for superiority over attenuating colonic damage. conclusion, this experimental evidence supporting potential therapeutic use or β-hydroxybutyrate-boosting regimens UC.

Language: Английский

Citations

26
Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living DOI Creative Commons
George Lagoumintzis, George P. Patrinos

Human Genomics, Journal Year: 2023, Volume and Issue: 17(1)

Published: Dec. 8, 2023

Abstract The unique physiological and genetic characteristics of individuals influence their reactions to different dietary constituents nutrients. This notion is the foundation personalized nutrition. field nutrigenetics has witnessed significant progress in understanding impact variants on macronutrient micronutrient levels individual's responsiveness intake. These hold value facilitating development nutritional interventions, thereby enabling effective translation from conventional guidelines genome-guided Nevertheless, certain obstacles could impede extensive implementation individualized nutrition, which still its infancy, such as polygenic nature nutrition-related pathologies. Consequently, many disorders are susceptible collective multiple genes environmental interplay, wherein each gene exerts a moderate modest effect. Furthermore, it widely accepted that diseases emerge because intricate interplay between predisposition external influences. In context this specific paradigm, utilization advanced "omic" technologies, including epigenomics, transcriptomics, proteomics, metabolomics, microbiome analysis, conjunction with comprehensive phenotyping, potential unveil hitherto undisclosed hereditary elements interactions environment. review aims provide up-to-date information regarding fundamentals specifically emphasizing complex triangulation among microbiota, metabolites, genes. highlights intestinal microbiota's makeup, nutrigenomics, tailoring suggestions. Finally, article provides an overview genotyping versus microbiomics, focusing investigating applications knowledge tailored plans aim improve human well-being overall health.

Language: Английский

Citations

23
Revealing the Urinary Microbiota in Prostate Cancer: A Comprehensive Review Unveiling Insights into Pathogenesis and Clinical Application DOI Creative Commons
Fakhri Alajeeli, Abdullah Salim Al-Karawi,

Fadhil M. Abid

et al.

Al-Salam Journal for Medical Science, Journal Year: 2024, Volume and Issue: 3(1), P. 45 - 54

Published: Jan. 13, 2024

Prostate cancer is one of the most common malignancies and seriously affects public health. Recently, contemporary microbiome research has found hints that urinary microflora may at least to some extent impact prostate formation treatment outcomes. A comprehensive review This article attempts provide a brief summary integration current knowledge about involvement in development by microbiota, diagnostic capabilities, as well therapeutic opportunities.It examines different microbial spheres inside residents genitourinary system their relevance tumorigenic microenvironments. The looks signatures linked cancer, tries identify potential biological markers for diagnosis disease or patient stratification according risk levels, predictors outcome. Secondly, effect urine microbiota upon response how design novel interventions also form key topics this study.After existing literature recent new studies, illuminate intricate interrelationships between cancer. It hoped effort will insight on future directions research, clinical applications even possibilities precision-medicine paradigms care.

Language: Английский

Citations

11
State of the art and the future of microbiome-based biomarkers: a multidisciplinary Delphi consensus DOI Creative Commons
Julie Rodriguez,

Zahra Hassani,

Carolina Alves Costa Silva

et al.

The Lancet Microbe, Journal Year: 2024, Volume and Issue: unknown, P. 100948 - 100948

Published: Sept. 1, 2024

Language: Английский

Citations

8
Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

Citations

1