Dysregulation of proBDNF/p75NTR and BDNF/TrkB Signaling in Acute Ischemic Stroke: Different Sides of the Same Coins DOI Creative Commons

Hala Alnoaman,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111338 - 111338

Published: April 1, 2025

Acute ischemic stroke (AIS) is a focal neurological deficit due to sudden occlusion of cerebral vessels in the brain. AIS-induced neuronal injury and associated excite-toxicity neurodegeneration affect synthesis release different neurotrophic factors such as brain-derived neurotropic factor (BDNF) its precursor proBDNF. Both BDNF proBDNF act on specific receptors with effects. activates tropomyosin receptor kinase B (TrkB) results promoting survival, synaptic plasticity, growth. However, p75 neurotrophin (p75NTR) sortilin which attenuates plasticity promotes apoptosis. Dysregulation central peripheral expression proBDNF/BDNF linked severity clinical outcomes AIS. Therefore, this review aims discuss alterations signaling Findings from present illustrated that proBDNF/p75NTR/sortilin pathway exaggerated whereas; BDNF-TrkB reduced AIS leading activation signaling, inhibition could be promising therapeutic strategy management

Language: Английский

Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective DOI
Sarah Albogami, Hayder M. Al‐kuraishy,

Thabat J. Al‐Maiahy

et al.

Current Hypertension Reports, Journal Year: 2022, Volume and Issue: 24(12), P. 687 - 692

Published: Nov. 7, 2022

Language: Английский

Citations

30
Montelukast and Acute Coronary Syndrome: The Endowed Drug DOI Creative Commons

Basil Mohammed Alomair,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(9), P. 1147 - 1147

Published: Sept. 14, 2022

Acute coronary syndrome (ACS) is a set of signs and symptoms caused by reduction blood flow with subsequent myocardial ischemia. ACS associated activation the leukotriene (LT) pathway releases various LTs, including LTB4, LTC4, LTD4, which cause inflammatory changes induction immunothrombosis. LTs through cysteine (CysLT) induce platelets clotting factors succeeding thrombosis. CysLT receptor (CysLTR) antagonists such as montelukast (MK) may reduce risk development complications suppression platelet factors. Thus, this critical review aimed to elucidate possible protective role MK in management ACS. The LT implicated pathogenesis atherosclerosis, cardiac hypertrophy, heart failure. Inhibition CysL1TR might be effective preventing cardiovascular complications. could an novel therapy inhibition pro-inflammatory CysLT1R modulation signaling pathways. can attenuate thrombotic events inhibiting that are activated during In conclusion, agent reducing severity Experimental, preclinical, clinical studies recommended confirm potential therapeutic

Language: Английский

Citations

29
The potential effect of metformin on fibroblast growth factor 21 in type 2 diabetes mellitus (T2DM) DOI
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, ‏Hebatallah M. Saad

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(4), P. 1751 - 1760

Published: June 19, 2023

Language: Английский

Citations

18
Cholinergic dysfunction in COVID-19: frantic search and hoping for the best DOI Open Access
Eman Hassan Nadwa, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2022, Volume and Issue: 396(3), P. 453 - 468

Published: Dec. 3, 2022

Language: Английский

Citations

28
The potential role of SARS‐CoV‐2 infection in acute coronary syndrome and type 2 myocardial infarction (T2MI): Intertwining spread DOI Creative Commons
Aseel Awad Alsaidan, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(3)

Published: March 1, 2023

Abstract Coronavirus disease 2019 (COVID‐19) is a novel pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It has been shown that SARS‐CoV‐2 infection‐induced inflammatory and oxidative stress associated endothelial dysfunction may lead to the development of coronary (ACS). Therefore, this review aimed ascertain link between infection ACS. ACS spectrum myocardial ischemia due sudden decrease in blood flow, ranging from unstable angina infarction (MI). Primary or type 1 MI (T1MI) mainly plaque rupture and/or erosion with subsequent occlusive thrombosis. Secondary (T2MI) cardiac systemic disorders without atherothrombotic disruption. Acute linked nonobstructive such as vasospasm, dilated cardiomyopathy, fibrosis, myocarditis. Furthermore, inflammation might affect atherosclerotic stability through augmentation preload afterload. Nevertheless, major vessels plaques develop minor during COVID‐19 since arteries are not initially primarily targeted low expression angiotensin‐converting enzyme vessels. In conclusion, hypercytokinemia, direct cardiomyocyte injury, dysregulation renin‐angiotensin system aggravate underlying cause new‐onset T2MI. As well, arrhythmias induced anti‐COVID‐19 medications could worsen

Language: Английский

Citations

15
The Important Role of Interleukin-2 in COVID-19 DOI Creative Commons

Leila Ghanbari Naeini,

Laleh Abbasi, Farzaneh Karimi

et al.

Journal of Immunology Research, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 13

Published: Aug. 22, 2023

There is controversial literature about the effects of interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify potential role IL-2 COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, Web Science. The deadline up December 2022. We applied no time limits for searching strategy. After retrieving articles from authors summarized data into two extraction tables. first table described changes second therapeutic interventions targeting cytokines. results on do not show a singular rule. can change during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some studies suggest that rise infection cause inflammatory response storm. These cytokines are shown be increased immunocompromised patients worsen their prognosis. In individuals without underlying disease, upregulation shows clinical outcome disease rises with severity. However, some other these significantly change. mostly upregulated healthy who had vaccination, but did significant after single dose vaccines, which need booster doses efficient also used as immunotherapy agents

Language: Английский

Citations

15
Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study DOI Creative Commons
Blanka Wolszczak-Biedrzycka, Justyna Dorf, Marzena Wojewódzka‐Żeleźniakowicz

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Aim The aim of the present study was to assess differences in serum levels chemokines and growth factors (GFs) between COVID-19 patients healthy controls. diagnostic utility analyzed proteins for monitoring severity SARS-CoV- 2 infection based on patients’ MEWS scores also assessed. Materials methods were hospitalized (50 women, 50 men) with use Bio-Plex Pro™ Human Cytokine Screening Panel (Biorad) Multiplex system. Results demonstrated that MIP-1α, RANTES, Eotaxin, CTACK, GRO-α, IP-10, MIG, basic-FGF, HGF, SCGF-β, G-CSF, M-CSF, SCF, MIF, LIF, TRAIL significant higher than control group. concentrations PDGF- BB, GM-CSF, asymptomatic/mildly symptomatic (stage 1) pneumonia without respiratory failure 2). receiver operating characteristic (ROC) analysis revealed basic-FGF differentiated from controls highest sensitivity specificity, whereas MIG 2) specificity. Conclusions GM-CSF can be useful biomarkers disease COVID-19.

Language: Английский

Citations

5
Long COVID and risk of erectile dysfunction in recovered patients from mild to moderate COVID-19 DOI Creative Commons
Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Sumaiah J. Alarfaj

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 12, 2023

Abstract Patients with coronavirus disease 2019 (COVID-19) were shown to have reduced serum testosterone levels compared healthy individuals. Low are linked the development of erectile dysfunction (ED). In this case-controlled study, 20 controls and 39 patients ED 3 months after recovering from mild-to-moderate COVID-19 pneumonia studied. The ranged in age 31 47 years. To identify early late infections, real-time polymerase-chain reaction (RT-PCR) antibody testing done. luteinizing hormone (LH), follicular stimulating (FSH), total (TT), free (FT), androgenic index (FAI), sex hormone-binding globulin (SHBG) measured. sexual health inventory for (SHIM) score was used measure function controls. When controls, TT level long (LC) low ( p = 0.01). contrast FT FAI both lower LC ED. 0.001). FSH did not significantly differ 0.07), but patients, LH elevated. SHIM scores associated 0.30), 0.09), high 0.76) Male decreased may hypothalamic-pituitary–gonadal axis dysfunction, which could lead LC-induced Therefore, an in-depth research is necessary confirm causal link between patients.

Language: Английский

Citations

13
Antidepressants and type 2 diabetes: highways to knowns and unknowns DOI Creative Commons

Nahi Sabih Alruwaili,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 15(1)

Published: Aug. 31, 2023

Abstract Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates progression depression in T2D patients. Therefore, management antidepressant agents improves glucose homeostasis sensitivity. However, prolong use drugs may increase risk for T2D. there strong controversy concerning this review try to elucidate potential effects regarding their detrimental beneficial effects.

Language: Английский

Citations

12
Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden DOI
Luay Alkazmi, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2023, Volume and Issue: 50(5), P. 335 - 352

Published: Feb. 3, 2023

Abstract Dantrolene (DTN) is a ryanodine receptor (RyR) antagonist that inhibits Ca 2+ release from stores in the sarcoplasmic reticulum. DTN mainly used management of malignant hyperthermia. RyRs are highly expressed immune cells and involved different viral infections, including severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2), because necessary for replication, maturation release. can inhibit proliferation SARS‐CoV‐2, indicating its potential role reducing entry pathogenesis SARS‐CoV‐2. may increase clearance SARS‐CoV‐2 promote disease 2019 (COVID‐19) recovery by shortening period infection. N‐methyl‐D‐aspartate (NMDA) mediated platelets aggregations thrombosis. Therefore, thrombosis coagulopathy COVID‐19 through suppression platelet NMDA receptors. Moreover, has neuroprotective effect against infection‐induced brain injury modulation receptors, which excitotoxicity, neuronal development neuropsychiatric disorders. In conclusion, inhibiting attenuate inflammatory disorders infection associated cardio‐pulmonary complications. DNT could be promising drug therapy COVID‐19. Preclinical clinical studies warranted this regards.

Language: Английский

Citations

11