Comparison of Ultrasound and Unenhanced CT for diagnosis of Hepatic Steatosis DOI Creative Commons

Muqaddass Fatima,

Eman Ikhlaq,

Zoaila Rafique

et al.

Journal of Health and Rehabilitation Research, Journal Year: 2023, Volume and Issue: 3(2), P. 544 - 549

Published: Dec. 14, 2023

Background: Hepatic steatosis, characterized by pathologically increased fat deposition in the liver, is a growing health concern, with Non-Alcoholic Fatty Liver Disease (NAFLD) being most common manifestation. This condition, which may escalate to cirrhosis and steatohepatitis, underscores need for effective diagnostic strategies. Various non-invasive imaging techniques are pivotal detecting hepatic steatosis (HS). Objective: The aim of this study was compare efficacy ultrasound unenhanced CT diagnosis determine reliable technique early detection. Methods: A cross-sectional conducted at Radiological Department Combined Military Hospital (CMH), Lahore, using convenience sampling method from April June 2023. involved 100 participants who underwent both (USG) scans. Data collection facilitated through structured performa, analysis executed SPSS version 26. Results: diagnosed USG Ultrasound assessments revealed that 23% patients had Grade I HS, 38% II, 20% III. Notably, 19% examinations showed no signs HS. In contrast, results indicated 24% disease an L/S index greater than 1, while 62% presented between 0.5 indicative critical finding 14% were III progressing less 0.5. Discrepancies modalities highlighted as displayed smooth liver parenchyma on contrasted irregular textures Conclusion: emerges viable initial modality diagnosing stages due its accessibility non-invasiveness. However, precise quantification content, scans provide superior accuracy. Such insights direct clinicians towards tailored approach management

Language: Английский

Non-invasive evaluation of liver steatosis with imaging modalities: New techniques and applications DOI Creative Commons
Keyu Zeng,

Wu-Yong-Ga Bao,

Yunhan Wang

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(17), P. 2534 - 2550

Published: May 5, 2023

In the world, nonalcoholic fatty liver disease (NAFLD) accounts for majority of diffuse hepatic diseases. Notably, substantial fat accumulation can trigger and accelerate fibrosis, thus contributing to progression. Moreover, presence NAFLD not only puts adverse influences but is also associated with an increased risk type 2 diabetes cardiovascular Therefore, early detection quantified measurement content are great importance. Liver biopsy currently most accurate method evaluation steatosis. However, has several limitations, namely, its invasiveness, sampling error, high cost moderate intraobserver interobserver reproducibility. Recently, various quantitative imaging techniques have been developed diagnosis content, including ultrasound- or magnetic resonance-based methods. These provide objective continuous metrics be recorded comparison when patients receive check-ups evaluate changes in which useful longitudinal follow-up. this review, we introduce describe their diagnostic performance content.

Language: Английский

Citations

22
Comparison of NAFLD, MAFLD And MASLD Prevalence And Clinical Characteristics in Asia Adults DOI
Xinjuan Huang,

Ruoling Yu,

Xinyun Tan

et al.

Journal of Clinical and Experimental Hepatology, Journal Year: 2024, Volume and Issue: 15(1), P. 102420 - 102420

Published: Oct. 8, 2024

Language: Английский

Citations

7
Nonalcoholic Fatty Liver Disease and Staging of Hepatic Fibrosis DOI
Atilla Engin

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 539 - 574

Published: Jan. 1, 2024

Language: Английский

Citations

5
Clinical and Biochemical Spectrum of APOB-Related Hypobetalipoproteinemia: Insights from a Retrospective Cohort Study DOI
İlknur Sürücü Kara, Engi̇n Köse, Hatice Mutlu Albayrak

et al.

Journal of clinical lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Adipocytokines as Predictors of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development in Type 2 Diabetes Mellitus Patients DOI Open Access
Almir Fajkić,

Rijad Jahić,

Almira Hadžović-Džuvo

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 6, 2024

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic condition. Due to pathophysiological processes, MASLD's relation type 2 diabetes mellitus (T2DM) still unclear, especially when the role of adipocytokines taken into consideration. Objective: This study aims examine potential predictive value adiponectin and resistin for MASLD in T2DM. Patients methods: In two-year study, 71 T2DM patients were categorized MASLD-T2DM non-MASLD-T2DM groups according development. Serum samples tested resistin, adiponectin, high-density lipoprotein cholesterol, fasting glucose, triglycerides. An appropriate equation used calculate adiponectin/resistin (A/R) index. The optimal cut-off values differentiating from non-MASLD determined using receiver operating characteristic (ROC) curves corresponding areas under curve (AUC). To predict onset with T2DM, logistic regression analysis was performed. Results: There significant differences (p<0.001), A/R index (p<0.001) between individuals without MASLD. ROC produced an AUC 0.997 sensitivity 96.1% specificity 100% point 253.15. Adiponectin (OR, 0.054; 95% CI, 0.011-0.268; p<0.001) 1.745; 1.195-2,548; p=0.004) found be independent predictors by analysis. Conclusion: confirms as development

Language: Английский

Citations

3
Head-to-head comparison of three different US-based quantitative parameters for hepatic steatosis assessment: a prospective study DOI
Yan Zhou,

Mengjin Nie,

Hongyu Zhou

et al.

Abdominal Radiology, Journal Year: 2024, Volume and Issue: 49(7), P. 2262 - 2271

Published: May 13, 2024

Language: Английский

Citations

3
Quantitative ultrasound (QUS) in the evaluation of liver steatosis: data reliability in different respiratory phases and body positions DOI Creative Commons
Aldo Rocca, Klara Komici,

Maria Chiara Brunese

et al.

La radiologia medica, Journal Year: 2024, Volume and Issue: 129(4), P. 549 - 557

Published: March 21, 2024

Abstract Liver steatosis is the most common chronic liver disease and affects 10–24% of general population. As grade can range from fat infiltration to steatohepatitis cirrhosis, an early diagnosis needed set appropriate therapy. Innovative noninvasive radiological techniques have been developed through MRI US. MRI-PDFF reference standard, but it not so widely diffused due its cost. For this reason, ultrasound tools validated study parenchyma. The qualitative assessment brightness parenchyma has now supported by quantitative values attenuation scattering make analysis objective reproducible. We aim demonstrate reliability in assessing confirm inter-operator different respiratory phases. enrolled 45 patients examined during normal breathing at rest, peak inspiration, expiration, semi-sitting position. highest agreement both parameters was achieved inspiration followed In conclusion, technology also allows monitor uncompliant patients, as grants high reproducibility body position

Language: Английский

Citations

3
An ultrasound multiparametric method to quantify liver fat using magnetic resonance as standard reference DOI Creative Commons
Laura De Rosa, A Salvati, Nicola Martini

et al.

Liver International, Journal Year: 2024, Volume and Issue: 44(11), P. 3008 - 3019

Published: Aug. 27, 2024

Abstract Background & Aims There is an unmet need for a reliable and reproducible non‐invasive measure of fatty liver content (FLC) monitoring steatotic disease in clinical practice. Sonographic FLC assessment qualitative operator‐dependent, the dynamic quantification range algorithms based on single ultrasound (US) parameter unsatisfactory. This study aims to develop validate new multiparametric algorithm B‐mode images quantify using Magnetic Resonance (MR) values as standard reference. Methods Patients with elevated enzymes and/or bright at US ( N = 195) underwent evaluation by MR US. Five US‐derived quantitative features [attenuation rate(AR), hepatic renal‐ratio(HR), diaphragm visualization(DV), hepatic‐portal‐vein‐ratio(HPV), portal‐vein‐wall(PVW)] were combined mixed linear/exponential regression model (Steatoscore2.0). One hundred thirty‐four subjects used training 61 independent validations; score‐computation inter‐operator reproducibility analysis. Results The combination 3 parameters (AR, HR, DV), modelled 2 equations according AR values. computation Steatoscore2.0 (mean ± std, 7.91% 8.69) 8.10% 10.31) highly correlated low root mean square error both training/validation cohorts, respectively R 0.92/0.86 RMSE 5.15/4.62, p < .001). identified patients MR‐FLC≥5%/≥10% sensitivity 93.2%/89.4%, specificity 86.1%/95.8%, AUROC 0.958/0.975, 0.92) significantly .001) better than CAP 0.73). Conclusions Multiparametric measures providing comparable MR. It reliable, inexpensive, easy use any equipment qualifies be tested larger, prospective studies tool screening FLC.

Language: Английский

Citations

2
Clinical Characteristics of Patients With Acquired Partial Lipodystrophy: A Multicenter Retrospective Study DOI Open Access
Silvia Magno, Giovanni Ceccarini, Fernando Corvillo

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(3), P. e932 - e944

Published: Dec. 7, 2023

Barraquer-Simons syndrome (BSS) is a rare, acquired form of lipodystrophy characterized by progressive loss upper body subcutaneous fat, which affects face, limbs, and trunk. The pathogenesis the disease not entirely known may involve autoimmune mechanisms.

Language: Английский

Citations

6
Glomerular Hyperfiltration: A Marker of Fibrosis Severity in Metabolic Associated Steatotic Liver Disease in an Adult Population DOI Open Access
Andrea Dalbeni, Marta Garbin, Mirko Zoncapè

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15837 - 15837

Published: Oct. 31, 2023

Glomerular hyperfiltration (GH) is an increase in the glomerular filtration rate, possibly progressing to chronic kidney disease (CKD). Metabolic-associated steatotic liver (MASLD) linked increased risk of CKD, especially if fibrosis present; however, association between GH and MASLD has not been explored. To evaluate prevalence its possible correlation with fibrosis. 772 consecutive patients ultrasound (mean age 47.3 ± 8.9 years, 67.1% males) were enrolled. was defined as estimated rate (eGFR) greater than upper quartile values cohort. Liver stiffness measurement (LSM) by FibroScan ≥ 7.2 kPa suggested present 20% patients, 30%. In total, 53.4% cohort obese, 40.9% hypertensive, 36.3% diabetic 70.8% dyslipidaemic. compared non-GH significantly younger (38.4 8.3 vs. 49.5 7.7, p < 0.001), higher LSM > (35.5% 29%, without any difference metabolic comorbidities. multivariate analysis, (OR 0.85, CI 95% 0.82–0.87) significant 1.83; 95%1.10–3.03) remained independently associated GH, regardless presence alterations nephrotoxic drugs. early marker renal damage, highly prevalent hepatic may be considered both recognition could prompt management factors aimed at preventing progression disease.

Language: Английский

Citations

4