Non-Invasive Diagnostic of NAFLD in Type 2 Diabetes Mellitus and Risk Stratification: Strengths and Limitations

Life, Journal Year: 2023, Volume and Issue: 13(12), P. 2262 - 2262

Published: Nov. 27, 2023

The progressive potential of liver damage in type 2 diabetes mellitus (T2DM) towards advanced fibrosis, end-stage disease, and hepatocarcinoma has led to increased concern for quantifying injury individual risk assessment. combination blood-based markers imaging techniques is recommended the initial evaluation NAFLD regular monitoring evaluate disease progression. Continued development ultrasonographic magnetic resonance methods accurate quantification steatosis as well promising tools detection high-risk NASH, have been noted. In this review, we aim summarize available evidence regarding usefulness non-invasive assessment T2DM. We focus on power limitations various diagnosis, stratification, patient that support their implementation clinical setting or research field.

Language: Английский

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Assessment of Hepatic Steatosis Using Ultrasound-Based Techniques: Focus on Fat Quantification

Clinical Ultrasound, Journal Year: 2024, Volume and Issue: 9(1), P. 1 - 17

Published: May 30, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic worldwide, affecting more than 30% of global population, and associated with increased liver-related morbidity mortality, extrahepatic complications. With increasing prevalence MASLD, there an urgent need for accessible, non-invasive methods to detect hepatic steatosis. Currently, biopsy magnetic resonance imaging proton density fat fraction are considered reference standards diagnosing steatosis; however, their invasiveness limited accessibility limit widespread use. Ultrasonography (US) a promising alternative owing its cost-effectiveness accessibility. Recently, quantitative US techniques have been developed commercialized by several vendors measure steatosis detecting changes in various acoustic properties steatosis, making it readily accessible. Controlled attenuation parameter (CAP), which evaluates using beam, widely studied algorithm as non-imaging technique. Several other algorithms also available on B-mode ultrasound systems, diagnostic performance comparable or better that CAP. Therefore, we aimed review current US-based grading discussing utilization.

Language: Английский

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Evolutive Models, Algorithms and Predictive Parameters for the Progression of Hepatic Steatosis

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 198 - 198

Published: April 3, 2024

The utilization of evolutive models and algorithms for predicting the evolution hepatic steatosis holds immense potential benefits. These computational approaches enable analysis complex datasets, capturing temporal dynamics providing personalized prognostic insights. By optimizing intervention planning identifying critical transition points, they promise to revolutionize our approach understanding managing progression, ultimately leading enhanced patient care outcomes in clinical settings. This paradigm shift towards a more dynamic, personalized, comprehensive progression signifies significant advancement healthcare. application allows nuanced characterization disease trajectories, facilitating tailored interventions decision-making. Furthermore, these tools offer framework integrating diverse data sources, creating holistic progression. In summary, benefits encompass ability analyze capture dynamics, provide insights, optimize planning, identify integrate sources. has management steatosis, improved

Language: Английский

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Pediatric metabolic (dysfunction)-associated fatty liver disease: current insights and future perspectives

Hepatology International, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract The historical use of the term non-alcoholic fatty liver disease (NAFLD) in obese/overweight children has been controversial as to appropriateness this terminology children, and lately, adults too. Newer game-changer terminology, metabolic (dysfunction)-associated (MAFLD), for condition signifies a positive step forward that addresses limitations previous definition both children. prevalence MAFLD surged tandem with global rise obesity rates, establishing itself predominant cause chronic adult pediatric populations. adoption recently proposed nomenclature reflects more encompassing comprehension its etiology compared predecessor, NAFLD. Notably, revised facilitates recognition an autonomous while acknowledging potential coexistence other systemic disorders. Particularly includes various paediatric-onset genetic inherited disorders, necessitating thorough exclusion, especially cases where weight loss interventions yield no improvement or absence obesity. presents multifaceted disorder; evidence suggests origins lie complex interplay nutritional, genetic, hormonal, environmental factors. Despite advancements, current non-invasive diagnostic biomarkers exhibit accuracy, often imaging histological evaluations definitive diagnosis. While dietary lifestyle modifications stand cornerstone measures prevention management, ongoing evaluation therapeutic agents continues. This article provides overview latest developments emerging therapies realm paediatric MAFLD.

Language: Английский

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Impact of Respiratory Motion on the Quantification of Pediatric Hepatic Steatosis Using Two Different Ultrasonography Machines

Yonsei Medical Journal, Journal Year: 2024, Volume and Issue: 65(10), P. 602 - 602

Published: Jan. 1, 2024

This study aimed to investigate the effect of respiratory motion on hepatic steatosis quantification using ultrasound attenuation imaging (ATI) or ultrasound-guided parameter (UGAP) in pediatric patients.

Language: Английский

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GIÁ TRỊ CỦA SIÊU ÂM ĐỊNH LƯỢNG MỠ GAN BẰNG KỸ THUẬT LFQ ĐỂ ĐÁNH GIÁ GAN NHIỄM MỠ CÓ THAM CHIẾU VỚI MRI-PDFF

VietNam Military Medical Unisversity, Journal Year: 2024, Volume and Issue: 49, P. 213 - 222

Published: April 17, 2024

Mục tiêu: Xác định giá trị của siêu âm lượng mỡ gan bằng kỹ thuật LFQ để đánh nhiễm (GNM). Phương pháp nghiên cứu: Nghiên cứu tiến cứu, mô tả cắt ngang trên 38 bệnh nhân (BN), tất cả được làm mode B, đo hệ số suy giảm AC và chụp MRI-PDFF tại Phòng khám Đa khoa 360 Lê Hoàn từ tháng 9/2023 - 12/2023. So sánh kết quả với MRI-PDFF. Kết quả: 13 BN không (34,2%) 25 GNM (65,8%) xác FF lần lượt là < 5,2% ³ 5,2%. Trong có MRI-PDFF, 8 (32,0%) thừa cân hay béo phì BMI 23 kg/m2. Siêu B chỉ nhận 16/25 (64,0%) trong Giá ngưỡng 0,62; 0,66 dB/cm/MHz tương ứng S1 (FF 5,2%), S2 11,3%) S3 17,1%) Phân tích đường cong ROC ra độ nhạy (Se), đặc hiệu (Sp), (cut-off) cũng như AUC 76,6%, 45,2%, 0,62, 0,766 80,0%, 65,7%, 0,66, 0,909 S2. luận: cách GNM. Đây đơn giản, dễ thực hiện thống sẵn có, chi phí thấp, thể áp dụng rộng rãi.

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Variability in Liver Size Measurements Using Different View Angles in Ultrasound Imaging

Journal of Ultrasound in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Purpose The aim of this study was to compare liver size measurements in different conventional B‐mode ultrasound image (US) field views using magnetic resonance imaging (MRI) measurement as a reference. Methods After receiving Institutional Review Board approval and informed consent, three operators measured the largest sagittal transverse dimensions adult livers on US (90°, 120°, 140°) with single curvilinear transducer. We analyzed differences across one‐way analysis variance (ANOVA) examined correlations between MRI Spearman regression. used 95% Bland–Altman limits agreement (95% LOA) analyze confidence interval for US. Intra‐observer inter‐observer reliability measuring were assessed intraclass correlation coefficient (ICC). Results Based length, 28 participants (7 men 21 women, mean age 43 years) divided into Group 1 (<17 cm, n = 10) or 2 (≥17 18). There significant difference ( P < .001) both groups. highest ultra‐wide‐view R .87 sagittal; .79 transverse). LOA also indicated good measurements. (ICC 0.82–0.98). Conclusion suggests that provides most accurate intra‐ inter‐operator reliability.

Language: Английский

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Cutoff value of ultrasonic attenuation coefficient by Att.PLUS technique for diagnosis and grading of hepatic steatosis using MRI-derived proton density fat fraction (MRI-PDFF) as a reference standard

WFUMB Ultrasound Open, Journal Year: 2024, Volume and Issue: 2(2), P. 100043 - 100043

Published: Dec. 1, 2024

Language: Английский

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The association of fructose and fiber consumption and physical activity with non-alcoholic fatty liver disease in children and adolescents: a cross-sectional study

BMC Nutrition, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 21, 2024

Non-alcoholic fatty liver disease (NAFLD) is emerging as the most prevalent in overweight and obese children. While no cure exists, dietary lifestyle modifications have been shown to improve condition. This study investigates relationship between fructose fiber consumption, physical activity, NAFLD A cross-sectional was conducted on 378 children aged 6–13 years. diagnosis confirmed via ultrasound, intake assessed using a 147-item food frequency questionnaire (FFQ). Physical activity evaluated Modifiable Activity Questionnaire (MAQ). Multivariable logistic regression models were applied determine associations. After excluding 53 participants due incomplete data, 325 included final analysis. The mean age 9.2 ± 1.7 years, 35% had NAFLD. No significant association found (OR: 0.67, 95% CI: 0.35–1.29, P = 0.221). However, higher of legume 0.48, 0.26–0.90, 0.03) nut 0.52, 0.28–0.95, 0.04) significantly associated with reduced risk showed trend towards but not statistically after adjustments 0.53, 0.22–1.04, 0.07). linked this population, from legumes nuts appeared protective. Further prospective studies are needed confirm these findings clarify role prevention.

Language: Английский

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Comparison of Ultrasound and Unenhanced CT for diagnosis of Hepatic Steatosis

Journal of Health and Rehabilitation Research, Journal Year: 2023, Volume and Issue: 3(2), P. 544 - 549

Published: Dec. 14, 2023

Background: Hepatic steatosis, characterized by pathologically increased fat deposition in the liver, is a growing health concern, with Non-Alcoholic Fatty Liver Disease (NAFLD) being most common manifestation. This condition, which may escalate to cirrhosis and steatohepatitis, underscores need for effective diagnostic strategies. Various non-invasive imaging techniques are pivotal detecting hepatic steatosis (HS). Objective: The aim of this study was compare efficacy ultrasound unenhanced CT diagnosis determine reliable technique early detection. Methods: A cross-sectional conducted at Radiological Department Combined Military Hospital (CMH), Lahore, using convenience sampling method from April June 2023. involved 100 participants who underwent both (USG) scans. Data collection facilitated through structured performa, analysis executed SPSS version 26. Results: diagnosed USG Ultrasound assessments revealed that 23% patients had Grade I HS, 38% II, 20% III. Notably, 19% examinations showed no signs HS. In contrast, results indicated 24% disease an L/S index greater than 1, while 62% presented between 0.5 indicative critical finding 14% were III progressing less 0.5. Discrepancies modalities highlighted as displayed smooth liver parenchyma on contrasted irregular textures Conclusion: emerges viable initial modality diagnosing stages due its accessibility non-invasiveness. However, precise quantification content, scans provide superior accuracy. Such insights direct clinicians towards tailored approach management

Language: Английский

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