Revue du Rhumatisme, Journal Year: 2023, Volume and Issue: 91(3), P. 327 - 337
Published: Oct. 6, 2023
JAMA Dermatology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 6, 2024
Importance Few studies have investigated the association between COVID-19 and autoimmune autoinflammatory connective tissue disorders; however, research with long-term observation remains insufficient. Objective To investigate risk of diseases after over an extended period. Design, Setting, Participants This retrospective nationwide population-based study Korea Disease Control Prevention Agency–COVID-19–National Health Insurance Service (K-COV-N) cohort. Individuals confirmed from October 8, 2020, to December 31, 2022, controls identified among individuals who participated in general health examination 2018 were included analysis. Exposures Confirmed COVID-19. Main Outcomes Measures Incidence disorders patients Various covariates, such as demographic characteristics, data, socioeconomic status, comorbidity profiles, balanced using inverse probability weighting. Results A total 6 912 427 participants (53.6% male; mean [SD] age, 53.39 [20.13] years) consisting 3 145 388 767 039 observational period more than 180 days included. Alopecia areata (adjusted hazard ratio [AHR], 1.11 [95% CI, 1.07-1.15]), alopecia totalis (AHR, 1.24 1.09-1.42]), vitiligo 1.04-1.19]), Behçet disease 1.45 1.20-1.74]), Crohn 1.35 1.14-1.60]), ulcerative colitis 1.15 1.04-1.28]), rheumatoid arthritis 1.09 1.06-1.12]), systemic lupus erythematosus 1.14 1.01-1.28]), Sjögren syndrome 1.13 1.03-1.25]), ankylosing spondylitis 1.02-1.20]), bullous pemphigoid 1.62 1.07-2.45]) associated higher group. Subgroup analyses revealed that factors, including male female sex, age younger 40 years, years older, exhibited diverse associations outcomes. In addition, severe infection requiring intensive care unit admission, Delta period, not being vaccinated risk. Conclusions Relevance cohort follow-up found various disorders. Long-term monitoring is crucial COVID-19, considering severity, vaccination mitigate these risks.
Language: Английский
Citations
6
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 129, P. 111599 - 111599
Published: Feb. 7, 2024
Olfactory impairment, particularly hyposmia and anosmia, has emerged as a distinctive early symptom of SARS-CoV-2. Drawing on the historical association autoimmune diseases with olfactory function, this study delves into connections between COVID-19, autoimmunity, persistent dysfunctions, focusing individuals experiencing long-lasting smell disorders (3–18 months post-SARS-CoV-2 infection). The comprised 36 Long Covid patients alongside two control groups. functionality was assessed using Sniffin' Sticks extended test. Non-invasive mucosa brushing nasal secretions were processed for samples, while serum samples obtained through peripheral venous sampling. A panel autoantibodies, including Immunocirculating Complexes, ANA, ENA, AECA, investigated in brush supernatant samples. Contrary to expectations, absence traditional autoantibodies challenges proposed etiology Covid-associated dysfunction. However, presence potential pathogenic role AECA suggest viral cytopathic inflammatory involvement specific anatomical districts. One hypothesis explores impact inflammation cytokine release induced by infection, altering neuronal signaling contributing hyposmia. This research contributes our understanding complex relationships COVID-19. classical prevailing theories, prominence hints at unique viral-induced mechanisms. By unraveling these complexities, enhances comprehension post-acute sequelae, offering valuable perspectives immune-mediated responses aftermath pandemic.
Language: Английский
Citations
5
Diagnostics, Journal Year: 2024, Volume and Issue: 14(4), P. 359 - 359
Published: Feb. 7, 2024
Olfactory dysfunction (OD) is one of the most common symptoms in COVID-19 patients and can impact patients’ lives significantly. The aim this review was to investigate multifaceted on olfactory system provide an overview magnetic resonance (MRI) findings neurocognitive disorders with COVID-19-related OD. Extensive searches were conducted across PubMed, Scopus, Google Scholar until 5 December 2023. included articles 12 observational studies 1 case report that assess structural changes structures, highlighted through MRI, 10 correlating loss smell or mood patients. MRI consistently indicate volumetric abnormalities, altered signal intensity bulbs (OBs), anomalies cortex among persistent correlation between OD deficits reveals associations cognitive impairment, memory deficits, depressive symptoms. Treatment approaches, including training pharmacological interventions, are discussed, emphasizing need for sustained therapeutic interventions. This points out several limitations current literature while exploring intricate effects its connection disorders. lack objective measurements some potential validity issues self-reports emphasize cautious interpretation. Our research highlights critical extensive larger samples, proper controls, deepen our understanding COVID-19’s long-term neurological dysfunctions.
Language: Английский
Citations
5
Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105967 - 105967
Published: March 1, 2025
Language: Английский
Citations
0
Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 4(1)
Published: May 15, 2024
Background: Neutrophil extracellular traps (NETs) are crucial for antimicrobial defense in sepsis, trapping and neutralizing pathogens while minimizing damage to host cells. traps, comprising nuclear chromatin, histones, cytoplasmic granules, significant. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggers multiple complications patients. Decondensed NETs associated proteins can become a critical source of autoantigens, presented the immune system, thereby inducing hyperinflammation autoimmunity sepsis viral diseases. Objectives: This study aimed explore NETosis its role disease 2019 (COVID-19). Methods: We reviewed PubMed database using keywords (autoimmune OR AND SARS-CoV-2 COVID-19 NETs) enhance understanding autoimmune diseases COVID-19, ultimately analyzing 55 articles. Results: play pivotal against pathogens. However, their overproduction lead self-tolerance failure system activation, contributing autoimmunity. Autoimmune phenomena have been observed many patients, with pathophysiology similar other infections that induce NET formation. Conclusions: may cause hyperactivation subsequent Like infections, could significant SARS-CoV-2. Modulating formation degradation potentially reduce severity disease.
Language: Английский
Citations
1
Neuroscience and Behavioral Physiology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 2, 2024
Language: Английский
Citations
0
Сенсорные системы, Journal Year: 2024, Volume and Issue: 38(1), P. 3 - 29
Published: May 21, 2024
Language: Английский
Citations
0
Revue du Rhumatisme, Journal Year: 2023, Volume and Issue: 91(3), P. 327 - 337
Published: Oct. 6, 2023
Citations
0