Recent nanotheranostic approaches in cancer research

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 19, 2024

Abstract Humanity is suffering from cancer which has become a root cause of untimely deaths individuals around the globe in recent past. Nanotheranostics integrates therapeutics and diagnostics to monitor treatment response enhance drug efficacy safety. We hereby propose discuss all imaging diagnostic tools, mechanism targeting tumor cells, current nanotheranostic platforms available for cancer. This review discusses various agents novel molecular tools like MRI, CT, PET, SPEC, PAT used diagnostics. Emphasis given gold nanoparticles, silica, liposomes, dendrimers, metal-based agents. also highlight limitations different field research treatment. Due complexity this area, multifunctional hybrid nanoparticles functionalized with targeted moieties or anti-cancer drugs show best feature theranostics that enables them work on carrying delivering active materials desired area requirement early detection diagnosis. Non-invasive techniques have specificity receptor binding internalization processes nanosystems within cells. may provide appropriate medicine at dose patient time. Graphical abstract

Language: Английский

---

Tumor microenvironment responsive metal nanoparticles in cancer immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 27, 2023

Malignant tumors have a unique tumor microenvironment (TME), which includes mild acidity, hypoxia, overexpressed reactive oxygen species (ROS), and high glutathione (GSH) levels, among others. Recently, TME regulation approaches attracted widespread attention in cancer immunotherapy. Nanoparticles as drug delivery systems ability to modulate the hydrophilicity of drugs affect uptake efflux tumor. Especially, metal nanoparticles been extensive applied for immunotherapy due their physical properties elaborate design. However, potential deficiencies low biodegradability, toxicity treatment side effects restrict clinical application. In this review, we briefly introduce feature characteristics recent advances responsive addition, could be combined with other treatments, such chemotherapy, radiotherapy photodynamic therapy also is presented. Finally, challenges outlook improving antitumor efficiency, effect risks has discussed.

Language: Английский

---

Radioprotective Effect of Selenium Nanoparticles: A Mini Review

IET Nanobiotechnology, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 8

Published: Jan. 25, 2024

This study followed the PRISMA reporting guidelines to present results. A comprehensive search was performed on electronic databases such as PubMed, Scopus, Web of Sciences, and Science Direct. Initially, 413 articles were retrieved. After removing duplicates applying specific inclusion exclusion criteria, 10 finally included in this systematic review.

Language: Английский

---

A review of bismuth‐based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy

IET Nanobiotechnology, Journal Year: 2023, Volume and Issue: 17(4), P. 302 - 311

Published: May 4, 2023

Abstract About 50% of cancer patients receive radiation therapy. Despite the therapeutic benefits this method, toxicity in normal tissues is unavoidable To improve quality therapy, addition to other methods such as IMRT, IGRT, and high dose, nanoparticles have shown excellent potential when ionising applied target volume. Recently, bismuth‐based (BiNPs) become particularly popular therapy due their atomic numbers (Z), X‐ray attenuation coefficient, low toxicity, cost. Moreover, it easy synthesise a variety sizes shapes. This study aimed review effects NP its combination with compounds, synergies radiotherapy, discussed based on physical, chemical, biological interactions. Targeted non‐targeted NPs used radiotherapy radiosensitizers dose enhancement are described. The results reported literature were categorised into various groups. Also, has highlighted importance different forms treatment find highest efficiency for applying them suitable candidate future clinical applications.

Language: Английский

---

Nanomaterials as Theranostic Agents for Cancer Therapy

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(23), P. 21462 - 21495

Published: Nov. 29, 2023

The concept of theranostics is ground breaking in the area cancer remedy due to its capability integrate both therapeutic and diagnostic elements a single approach. This approach advantageous diagnose assess treatment simultaneously enabling identification optimum course. process includes real-time monitoring strategies through simultaneous delivery imaging agents. Nanocarriers or nanomaterials play vital role theranostic applications therapy. dual task provides various challenges. Imaging modalities are engineered enhance signal-to noise ratios while being rapidly eliminated. high-concentration accumulation curatives at site disease biocompatibility nanocarriers two important concerns considered for design nanostructures. Various have been integrated with other materials form composite efficacy along diagnosing ability. In this report, overview metal, ceramic, polymer, small-molecule-based nanoparticulate systems presented applications.

Language: Английский

---

Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1841 - 1841

Published: Nov. 7, 2024

Proton therapy, characterized by its unique Bragg peak, offers the potential to optimize destruction of cancer cells while sparing healthy tissues, positioning it as one most advanced treatment modalities currently available. However, in comparison heavy ions, protons exhibit a relatively lower relative biological effectiveness (RBE), which limits efficacy proton therapy. The incorporation nanoparticles for radiosensitization presents novel approach enhance RBE protons. This review provides comprehensive discussion recent advancements augmenting effects therapy through use nanoparticles. It examines various types that have been focus extensive research, elucidates their mechanisms radiation sensitization, and evaluates factors influencing efficiency this sensitization process. Furthermore, discusses latest synergistic therapeutic strategies integrate nanoparticle-mediated outlines prospective directions future application conjunction with

Language: Английский

---

Roadmap on optical sensors

Journal of Optics, Journal Year: 2023, Volume and Issue: 26(1), P. 013001 - 013001

Published: Nov. 21, 2023

Abstract Optical sensors and sensing technologies are playing a more important role in our modern world. From micro-probes to large devices used such diverse areas like medical diagnosis, defence, monitoring of industrial environmental conditions, optics can be variety ways achieve compact, low cost, stand-off with extreme sensitivity selectivity. Actually, the challenges design functioning an optical sensor for particular application requires intimate knowledge optical, material, properties that affect its performance. This roadmap on addresses different areas. It is constituted by twelve contributions authored world-leading experts, providing insight into current state-of-the-art their respective fields face. Two articles address area fibre sensors, encompassing both conventional specialty fibres. Several other dedicated laser-based micro- nano-engineered whispering-gallery mode plasmonic sensors. The use chemical, biological biomedical discussed some papers. Different approaches required satisfy applications at visible, infrared THz spectral regions also discussed.

Language: Английский

---

A review of recent advances in the modeling of nanoparticle radiosensitization with the Geant4-DNA toolkit

Radiation Physics and Chemistry, Journal Year: 2023, Volume and Issue: 212, P. 111146 - 111146

Published: July 1, 2023

Language: Английский

---

Nanocomposite fibers based on cellulose acetate loaded with fullerene for cancer therapy: preparation, characterization and in-vitro evaluation

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 29, 2023

Abstract The current prevalence of cancerous diseases necessitates the exploration materials that can effectively treat these conditions while minimizing occurrence adverse side effects. This study aims to identify with potential inhibit metastasis within human body concurrently serving as therapeutic agents for their treatment. A novel approach was employed enhance anti-cancer properties electrospun cellulose fibers by incorporating fullerene nanoparticles (NPs) into acetate (CA) fibers, resulting in a composite material called Fullerene@CA. development aimed at utilizing fullerenes applications. process has been demonstrated vitro against various types cancer, and it found Fullerene@CA nanocomposite displayed robust anticancer activity. Cancer cells (Caco-2, MDA-MB 231, HepG-2 cells) were inhibited 0.3 0.5 mg.g −1 doses 58.62–62.87%, 47.86–56.43%, 48.60–57.73%, respectively. tested cancer shrink lose spindle shape due morphological changes. investigation prepared reveals its impact on genes, such BCL2, NF-KB, p53, Bax, p21, highlighting compounds' effectiveness. experimental results incorporation NPs CA resulted significant improvement efficacy. Therefore, is suggested modified could be utilized treatment prevention metastasis.

Language: Английский

---

Tumor Diagnosis and Treatment Based on Stimuli‐Responsive Aggregation of Gold Nanoparticles

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

ABSTRACT Gold nanomaterials have been used in the diagnosis and treatment of different tumors due to their unique physical chemical properties. Among them, gold nanoparticles with stimuli‐responsive aggregation functions attracted extensive attention because they can meet needs tumor at stages through structural changes. However, how effectively modify achieve transformation for specific stimuli, role corresponding improving effect still lack systematic summary. In this review, we comprehensively summarized current strategies inducing its advances treatment.

Language: Английский

---