Silver nanoparticles formulation of Marrubium alysson L. phenolic extract potentiates cytotoxicity through apoptosis with molecular docking study as Bcl-2 inhibitors DOI
Nermeen A. Eltahawy, Shady A. Swidan, Mohamed S. Nafie

et al.

Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: 42(22), P. 12077 - 12089

Published: Oct. 10, 2023

Crude or semi-purified extracts of plants can play a significant role as antitumor agents. They were used stabilizing and reducing agents in the preparation silver nanoparticles (AgNPs) that allows these particles to have more efficient cytotoxic activity. In current study, extract

Language: Английский

Advancements in tantalum based nanoparticles for integrated imaging and photothermal therapy in cancer management DOI Creative Commons
Ikhazuagbe H. Ifijen,

Awoyemi Taiwo Christopher,

Ogunnaike Korede Lekan

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(46), P. 33681 - 33740

Published: Jan. 1, 2024

Tantalum-based nanoparticles (TaNPs) have emerged as promising tools in cancer management, owing to their unique properties that facilitate innovative imaging and photothermal therapy applications.

Language: Английский

Citations

3

Tailoring Nanoscale Metal–Organic Frameworks (MOFs) for Medical Imaging Applications DOI

Omotayo Aderinoye,

Sreejith Raveendran

Biological and medical physics series, Journal Year: 2025, Volume and Issue: unknown, P. 241 - 260

Published: Jan. 1, 2025

Language: Английский

Citations

0

Advancements in nanomedicine: Precision delivery strategies for male pelvic malignancies – Spotlight on prostate and colorectal cancer DOI Creative Commons
Guodong Yang, Yu Cao, Xinyi Yang

et al.

Experimental and Molecular Pathology, Journal Year: 2024, Volume and Issue: 137, P. 104904 - 104904

Published: May 25, 2024

Pelvic malignancies consistently pose significant global health challenges, adversely affecting the well-being of male population. It is anticipated that clinicians will continue to confront these cancers in their practice. Nanomedicine offers promising strategies revolutionize treatment pelvic by providing precise delivery methods aim improve efficacy therapeutic outcomes while minimizing side effects. Nanoparticles are designed encapsulate agents and selectively target cancer cells. They can also be loaded with theragnostic agents, enabling multifunctional capabilities.

Language: Английский

Citations

2

Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate as Novel Potential MRI Nano-Agent for Breast Cancer Detection DOI Creative Commons

Fahimeh Aminolroayaei,

Daryoush Shahbazi‐Gahrouei, Mahboubeh Rostami

et al.

Micromachines, Journal Year: 2023, Volume and Issue: 14(4), P. 741 - 741

Published: March 27, 2023

Polyoxometalates (POMs) are mineral nanoclusters with many advantages in various diagnostic fields, particular cancer detection. This study aimed to synthesize and evaluate the performance of gadolinium-manganese-molybdenum polyoxometalate (Gd-Mn-Mo; POM) nanoparticles coated chitosan-imidazolium (POM@CSIm NPs) for detecting 4T1 breast cells by magnetic resonance imaging vitro vivo. The POM@Cs-Im NPs were fabricated characterized FTIR, ICP-OES, CHNS, UV-visible, XRD, VSM, DLS, Zeta potential, SEM. Cytotoxicity, cellular uptake, MR vivo L929 also assessed. efficacy was demonstrated using images BALB/C mice bearing a tumor evaluation cytotoxicity designed showed their high biocompatibility. In fluorescence flow cytometry, had higher uptake rate than (p < 0.05). Furthermore, significantly increased signal strength images, its relaxivity (r1) calculated as 4.71 mM-1 s-1. confirmed attachment selective accumulation region. Overall, results that POM@CSIm have considerable potential an nano-agent early

Language: Английский

Citations

5

Enhancement of skin tumor laser hyperthermia with Ytterbium nanoparticles: numerical simulation DOI
Zamrood A Othman, Yousif M. Hassan, A. Karim

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(3), P. 035021 - 035021

Published: March 28, 2024

Abstract Laser hyperthermia therapy (HT) has emerged as a well-established method for treating cancer, yet it poses unique challenges in comprehending heat transfer dynamics within both healthy and cancerous tissues due to their intricate nature. This study investigates laser HT promising avenue addressing skin cancer. Employing two distinct near-infrared (NIR) beams at 980 nm, we analyze temperature variations tumors, employing Pennes’ bioheat equation our fundamental investigative framework. Furthermore, delves into the influence of Ytterbium nanoparticles (YbNPs) on predicting distributions tissues. Our findings reveal that application YbNPs using Gaussian beam shape results notable maximum increase 5 °C tumor compared nanoparticle-free heating. Similarly, utilizing flat top alongside induces rise 3 °C. While this research provides valuable insights with configuration cancer treatment, more thorough understanding could be attained through additional details experimental parameters such setup, exposure duration, specific implications therapy.

Language: Английский

Citations

1

Nanotheranostic Approach for the Management of Colorectal Cancer DOI
Saloni Sharma, Gowthamarajan Kuppusamy,

Parikshit Roy Chowdhury

et al.

Nanoscience &amp Nanotechnology-Asia, Journal Year: 2023, Volume and Issue: 14(3)

Published: Aug. 23, 2023

: Colorectal Cancer (CRC) is a highly prevalent and the most frequent reason for death. The choice of nanotheranostic technology management colorectal cancer one emerging strategies to overcome (CRC). Magnetic nanoparticles are employed in this case because they have biomedical applications, such as diagnostic imaging, thermal treatment, medication transport. There has been evidence usage various chemicals on surface nano-particles, ligands, highlight contact with tumour cells at target region order induce effective cytotoxic drug release. This review will current breakthroughs targeting magnetic against cancer, well selection ligands their cellular targets ionizing radiation employing vitro vivo energies management.

Language: Английский

Citations

2

Assessment of antiproliferative activity of green-synthesized nickel oxide nanoparticles against glioblastoma cells using Terminalia chebula DOI Creative Commons
Long Sui,

Lu Hui,

Dou Yanli

et al.

Green Processing and Synthesis, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract The present study investigates the effect of nickel oxide nanoparticles (NiO-NPs) on C6 glioma cells and develops a method for preparing NiO. Plant-based materials (leaf extract) can produce NPs efficiently economically. Therefore, we developed NiO-NPs from Terminalia chebula leaf extract to reduce glioblastoma cell proliferation. structural, optical, antimicrobial properties were investigated. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2 H -tetrazolium bromide (MTT) assays, Acridine orange/ethidium dual staining, Hoechst 33342, Rh123 staining used evaluate nuclear changes mitochondrial membrane potential (MMP) in cells. X-ray diffraction analyses revealed cubic structures synthesized NiO-NPs, field emission scanning electron microscope analysis polygonal an energy-dispersive spectrometer confirmed high purity NiO-NPs. V. cholera, S. pneumonia, aureus, B. subtilis, P. aeruginosa, K. C. albicans sensitive When applied at lower concentrations rat cells, they dose-dependently inhibited viability induced apoptosis. Our findings show that exhibit altered MMP integrity. In this study, using T. extract, which has antiproliferative properties, increased cytotoxicity Further exploration animal models should be

Language: Английский

Citations

0

Proflavine Binding to La-Sr Perovskite Manganite Nanoparticles at Temperatures Above and Below the Сurie Temperature DOI

Eugen Dukhopelnikov,

Iuliia Blyzniuk,

Ekaterina Bereznyak

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0

Metal nanoparticles and their toxicity impacts on microorganisms DOI

Arulanandar Abishagu,

P. Kannan, Sivakumar Uthandi

et al.

Biologia, Journal Year: 2024, Volume and Issue: 79(9), P. 2843 - 2862

Published: July 31, 2024

Language: Английский

Citations

0

Proflavine binding to La-Sr perovskite manganite nanoparticles at temperatures above and below the Сurie temperature DOI
E. V. Dukhopelnikov, Julia N. Blyzniuk, Ekaterina Bereznyak

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135465 - 135465

Published: Sept. 1, 2024

Language: Английский

Citations

0