Bioanalysis,
Journal Year:
2023,
Volume and Issue:
15(21), P. 1287 - 1303
Published: Oct. 19, 2023
Background:
Alternatives
to
phlebotomy
in
clinical
trials
increase
options
for
patients
and
clinicians
by
simplifying
increasing
accessibility
trials.
The
authors
investigated
the
technical
logistical
considerations
of
one
technology
compared
with
phlebotomy.
Methodology:
Paired
samples
were
collected
from
16
donors
via
a
second-generation
serum
gel
microsampling
device
conventional
Microsamples
subject
alternative
sample
handling
conditions
evaluated
quality,
testing
proteome
profiling.
Results:
Timely
centrifugation
blood
microsamples
largely
preserved
analyte
stability.
Conclusion:
Centrifugation
timing
impacts
quality
specific
chemistry
protein
biomarkers.
Microsampling
devices
remote
refrigerated
shipping
can
decrease
patient
burden,
expand
trial
populations
aid
decisions.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(1), P. 46 - 46
Published: Jan. 11, 2024
Blood
serves
as
the
primary
global
biological
matrix
for
health
surveillance,
disease
diagnosis,
and
response
to
drug
treatment,
holding
significant
promise
personalized
medicine.
The
diverse
array
of
lipids
metabolites
in
blood
provides
a
snapshot
both
physiological
pathological
processes,
with
many
routinely
monitored
during
conventional
wellness
checks.
method
involves
intravenous
collection,
extracting
few
milliliters
via
venipuncture,
technique
limited
clinical
settings
due
its
dependence
on
trained
personnel.
Microsampling
methods
have
evolved
be
less
invasive
(collecting
≤150
µL
capillary
blood),
user-friendly
(enabling
self-collection),
suitable
remote
collection
longitudinal
studies.
Dried
spot
(DBS),
pioneering
microsampling
technique,
dominates
research
domains.
Recent
advancements
device
technology
address
critical
limitations
classical
DBS,
specifically
variations
hematocrit
volume.
This
review
presents
comprehensive
overview
state-of-the-art
devices,
emphasizing
their
applications
potential
monitoring
blood.
scope
extends
areas,
encompassing
population
studies,
nutritional
investigations,
discovery,
sports
medicine,
multi-omics
research.
Clinical Chemistry and Laboratory Medicine (CCLM),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 24, 2024
Abstract
The
introduction
of
the
vacuum
tube
in
1949
revolutionized
blood
collection,
significantly
improving
sample
quality
and
patient
comfort.
Over
past
75
years,
laboratory
diagnostics
have
evolved
drastically,
from
manual
to
automated
processes,
reducing
required
test
volumes
by
over
1,000
times.
Despite
these
advancements,
venous
collection
presents
logistical
challenges,
including
centralized
scheduling
a
large
volume
biological
waste
due
imbalance
between
needed
(often
very
little)
collected
excess).
COVID-19
pandemic
further
emphasized
need
for
decentralized
healthcare
solutions
empowerment.
Capillary
widely
used
point-of-care
testing,
offers
promising
alternative,
particularly
patients
facing
frequently,
or
difficulties
with,
sampling.
Leiden
University
Medical
Center
Netherlands
experienced
15
%
reduction
tests
during
after
pandemic,
attributed
preference
local
testing.
To
address
self-sampling
devices
are
emerging,
empowering
streamlining
logistics.
However,
challenges
such
as
cost,
transportation
regulations,
adequacy
persists.
Robust
tailored
total
lab
automation
sustainable
practices
crucial
widespread
adoption.
hurdles,
integration
into
diagnostic
processes
is
inevitable,
heralding
shift
towards
patient-centered,
proactive
healthcare.
Practical
recommendations
include
robust
device
design,
ease
use,
affordability,
sustainability,
sufficient
acceptability
seamless
workflows.
Although
obstacles
remain,
represents
future
diagnostics,
offering
convenience,
cost-effectiveness,
interoperability
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(18)
Published: March 7, 2024
Abstract
Conventional
venipuncture
is
invasive
and
challenging
in
low
middle‐income
countries.
Conversely,
point‐of‐care
devices
paired
with
fingersticks,
although
less
invasive,
suffer
from
high
variability
blood
volume
collection.
Recently
approved
microsampling
address
some
of
these
issues
but
remain
cost‐prohibitive
for
resource‐limited
settings.
In
this
work,
a
cost‐effective
device
described
the
collection
liquid
minimal
invasiveness
sufficient
retrieval
laboratory
analyses
or
immediate
testing.
Inspired
by
anatomy
sanguivorous
leeches,
single‐use
features
storage
compartment
microneedle
patch
hidden
within
suction
cup.
Finite
Element
Method
simulations,
corroborated
mechanical
analyses,
guide
material
selection
fabrication
design
optimization.
piglets,
successfully
collects
≈195
µL
invasiveness.
Additionally,
tailor‐made
lid
adapter
enable
safe
fluid
transportation
integration
commercially
available
systems
on‐site
respectively.
Taken
together,
proposed
platform
holds
significant
promise
enhancing
healthcare
pediatric
population
improving
patient
compliance
reducing
risk
needlestick
injuries
through
concealed
microneedles.
Most
importantly,
given
its
fabrication,
open‐source
may
have
meaningful
impact
Clinical Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
116(3), P. 782 - 794
Published: April 26, 2024
Low-volume
sampling
devices
offer
the
promise
of
lower
discomfort
and
greater
convenience
for
patients,
potentially
reducing
patient
burden
enabling
decentralized
clinical
trials.
In
this
study,
we
determined
whether
low-volume
produce
pharmacokinetic
(PK)
data
comparable
to
conventional
venipuncture
a
diverse
set
monoclonal
antibodies
(mAbs)
small
molecules.
We
adopted
an
open-label,
non-randomized,
parallel-group,
single-site
study
design,
with
four
cohorts
10
healthy
subjects
per
arm.
The
drugs,
doses,
routes
administration
included:
crenezumab
(15
mg/kg,
intravenous
infusion),
etrolizumab
(210
mg,
subcutaneous),
GDC-X
(oral),
hydroxychloroquine
(HCQ,
200
oral).
Samples
were
collected
after
single
dose
each
drug
using
three
capillary
devices:
TassoOne
Plus
liquid
blood,
Tasso-M20
dry
both
applied
arm,
Neoteryx
Mitra®
blood
obtained
from
fingertips.
Serum/plasma
concentrations
samples
overlapped
PK
parameters
all
except
HCQ.
After
applying
baseline
hematocrit
value,
two
those
venipuncture.
For
molecules,
bridging
strategies
evaluated
converting
equivalent
plasma
concentrations.
A
correction
and/or
linear
regression-based
was
effective
GDC-X,
but
not
Additionally,
bioanalytical
quality
comparability
various
collection
methods,
as
well
preference
devices.
Current HIV/AIDS Reports,
Journal Year:
2025,
Volume and Issue:
22(1)
Published: Feb. 26, 2025
This
perspective
explores
the
impact
of
home-based
sexual
health
services
on
accessibility
to
STI
and
HIV
testing
for
priority
populations.
study
evaluates
as
independent
care
options
complementary
components
traditional
clinic-based
care.
Challenges
persons
attend
can
be
overcome
by
offering
lower
threshold
Implementing
has
successfully
reached
populations,
including
previously
untested
men
who
have
sex
with
(MSM)
individuals
a
high
exposure
risk
sexually
transmitted
infections
(STI)
human
immunodeficiency
virus
(HIV),
attending
location-based
A
challenge
in
is
ensure
equitable
care,
such
limited
access
digital
resources
or
low
literacy.
While
enhance
healthcare,
research
into
needs
still
underserved
populations
subsequent
tailoring
offered,
needed.
Continuous
monitoring
evaluation
implementation
may
maximize
advantages
this
promising
type
Sexually Transmitted Diseases,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 11, 2024
ABSTRACT
Background
Home-based
sampling
could
create
accessible
testing
opportunities
for
men
who
have
sex
with
(MSM)
use
pre-exposure
prophylaxis
(PrEP).
Blood
collection
is
required
the
most
reliable
laboratory
results
HIV
and
syphilis
testing.
An
innovative
blood-collection
method
(Tasso+)
creates
a
vacuum
semi-automatically
collects
larger
volumes
of
blood
from
upper
arm.
This
study
aims
to
assess
acceptability
feasibility
this
device
among
PrEP-using
MSM
performance
blood-collection.
Methods
Between
August
2022
January
2023,
47
were
recruited
during
their
routine
PrEP
consultations
at
Dutch
Centre
Sexual
Health.
Participants
tested
directly
after
consultation,
an
online
questionnaire
determined
feasibility.
residual
serum
measured
Results
Of
participants,
87%
had
positive
attitude
toward
device,
77%
would
it
again
self-sampling
home.
rated
as
easy
(96%).
On
average
536
μl
whole
(244
serum)
was
collected.
All
samples
syphilis,
sufficient
(91%)
(89%).
Most
(85%)
220
blood,
further
(e.g.,
confirmation).
Conclusions
that
arm
highly
acceptable
by
users
performs
well
in
multiple
tests.
has
promising
potential
home-based
sexual
health
care
MSM.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(5), P. e0304155 - e0304155
Published: May 29, 2024
Background
Home
blood
self-collection
devices
can
enable
remote
monitoring,
but
their
implementation
requires
validation.
Our
objectives
were
to
explore
(i)
the
impact
of
sampling
sites
and
topical
analgesia
on
capillary
volume
pain
perception
(ii)
safety,
acceptability,
failure
among
adults
children
using
Tasso-SST
device.
Methods
We
conducted
a
two-phase
study.
The
investigational
phase
consisted
two
on-site
cross-sectional
studies
in
healthy
adult
participants
(≥
12
years)
(1–17
with
accompanying
parent.
Adults
received
4
samplings,
where
puncture
randomized
factorial
design,
venipuncture;
(and
one
parent)
had
sampling.
co-primary
outcomes
pain.
was
multicentre
trials
choosing
visits;
volume,
collection
failure,
adverse
events,
satisfaction
documented.
Results
In
,
90
9
7
parents
enrolled;
15
2
preschoolers
participated
.
study,
device
collected
median
(25%,
75%)
450
(250,
550)
μl
no
significant
difference
between
site,
analgesia,
its
interaction.
Using
reduced
by
0.61
(95%
CI:
0.97,
0.24;
P
<0.01)
points
11-point
scale;
reduction
varied
lower
back
showing
most
decrease.
Overall,
combining
all
phases,
425
500)
μl,
rate
4.4%;
minor
effects
reported
8.9%
participants,
willing
use
again.
Conclusion
Capillary
self-collection,
yielding
slightly
less
than
500
proves
be
safe
relatively
painless
method
for
children,
high
low
rates.
site
do
not
affect
could
reduce
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
Abstract
Calcium
phosphate
(CaP)
polymorphs
are
non-toxic
and
biocompatible,
making
them
intriguing
for
a
variety
of
applications,
including
hard
tissue
regeneration,
medicine
delivery,
vaccine
development.
Investigating
the
mechanism
calcium
nucleation
development
is
critical
understanding
disorders
caused
by
pathological
mineralization
developing
biomimetic
materials
with
suitable
properties.
The
current
CaP
in
situ/batch
biomineralization
process
follows
crystal-formation
route
pre-nucleation
cluster
aggregation
particles
larger
than
500
microns.
However,
due
to
their
large
size,
synthesis
methods
may
have
limited
efficiency,
scalability,
particle
uniformity.
new
technologies
producing
nano-
microparticles
biomedicine
interesting
various
reasons.
In
this
context,
microfluidic-based
technology
developed,
distinct
microfluidic
parameters
altered,
chip
architecture
allows
fine
manipulation
reaction
parameters.
obtained
conditions
yielded
20-100-micron
crystal.
Furthermore,
approach
enables
straightforward
encapsulation
two
different
model
dyes:
methylene
blue
(MB)
rose
Bengal
(RB).
proposed
microfluidic-aided
technique
provides
viable
future
study
production
delivery
systems.
