Chronic Stress and Headaches: The Role of the HPA Axis and Autonomic Nervous System

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 463 - 463

Published: Feb. 13, 2025

Chronic stress significantly influences the pathogenesis of headache disorders, affecting millions worldwide. This review explores intricate relationship between and headaches, focusing on dysregulation hypothalamic-pituitary-adrenal (HPA) axis autonomic nervous system (ANS). Persistent could lead to neuroinflammation, increased pain sensitivity, vascular changes that contribute development progression. The bidirectional nature this creates a vicious cycle, with recurrent headaches becoming source additional stress. Dysregulation HPA ANS imbalance amplify susceptibility intensifying their frequency severity. While pharmacological interventions remain common, non-pharmacological approaches targeting reduction, such as cognitive-behavioral therapy, biofeedback, relaxation techniques, offer promising avenues for comprehensive management. By addressing underlying stress-related mechanisms, these provide sustainable strategy reduce improve patients' quality life.

Language: Английский

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The Role of Cortisol and Dehydroepiandrosterone in Obesity, Pain, and Aging

Diseases, Journal Year: 2025, Volume and Issue: 13(2), P. 42 - 42

Published: Feb. 1, 2025

Obesity, chronic pain, and aging are prevalent global challenges with profound implications for health well-being. Central to these processes adrenal hormones, particularly cortisol dehydroepiandrosterone (DHEA), along its sulfated form (DHEAS). Cortisol, essential stress adaptation, can have adverse effects on pain perception when dysregulated, while DHEA/S possess properties that may mitigate effects. This review explores the roles of in contexts obesity, acute aging, age-related diseases. We examine hormonal balance, specifically cortisol-to-DHEA ratio (CDR), as a key marker system functionality impact sensitivity, neurodegeneration, physical decline. Elevated CDR decreased levels associated worsened outcomes, including increased frailty, immune dysfunction, progression conditions such osteoporosis Alzheimer’s disease. synthesizes current literature highlight complex interplay between hormones their broader health. It aims provide insights into potential future therapies improve management promote healthy weight aging. By investigating mechanisms, this work contributes deeper understanding physiological intersections endocrine system.

Language: Английский

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Funktionelle Störungen bei chronisch-entzündlichen Darmerkrankungen – die Darm-Hirn-Achse

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

In patients with inflammatory bowel diseases (IBD), functional complaints frequently persist after the clearing of inflammation and are clinically difficult to distinguish from symptoms inflammation. recent years, influence bidirectional communication between gut brain on physiology, emotions, behavior has been demonstrated. What mechanisms underlie development gastrointestinal in irritable syndrome (IBS) IBD? therapeutic approaches arise this? Narrative review. The pathogenesis IBS involves interactions psychosocial factors, genetics, microbiota as well central peripheral nervous systems. interplay stress visceral hypersensitivity is importance. Therapeutically, lifestyle changes reduction exercise alongside dietary, pharmacological, psychotherapeutic options useful. treatment disorders remains challenging, pharmacological therapies often ineffective gut-directed psychotherapies rarely available.

Language: Английский

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Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders

World Journal of Clinical Pediatrics, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 18, 2025

BACKGROUND Functional gastrointestinal disorders (FGIDs) in children present with chronic symptoms like abdominal pain, diarrhea, and constipation without identifiable structural abnormalities. These are closely linked to gut-brain axis dysfunction, altered gut microbiota, psychosocial stress, leading psychiatric comorbidities such as anxiety, depression, behavioral issues. Understanding this bidirectional relationship is crucial for developing effective, holistic management strategies that address physical mental health. AIM To examine the impacts of FGIDs children, focusing on anxiety depression their association other neurodevelopmental childhood, attention-deficit/hyperactivity disorder, emphasizing role axis, emotional dysregulation, stress. Key mechanisms explored include neurotransmitter microbiota imbalance, central sensitization, heightening stress reactivity, symptom perception. The review also evaluates family dynamics coping exacerbating FGID contributing conditions. METHODS A narrative was conducted using 328 studies sourced from PubMed, Scopus, Google Scholar, covering research published over past 20 years. Inclusion criteria focused examining diagnosis, mechanisms, comorbidities, factors pediatric populations. commonly affecting including functional constipation, irritable bowel syndrome, gastroesophageal reflux, cyclic vomiting were analyzed concerning psychological impacts. RESULTS highlights a strong connection between symptoms, mediated by dysregulated sensitization. physiological disruptions increase children’s vulnerability while - early-life trauma, maladaptive dynamics, ineffective intensify cycle distress. CONCLUSION Effective requires biopsychosocial approach integrating medical, psychological, dietary interventions. Parental education, early intervention, multidisciplinary care coordination critical mitigating long-term improving both health outcomes FGIDs.

Language: Английский

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Hair Cortisol and Fe-BARQ: Evaluating Chronic Stress and Behavior in Cats with Chronic Kidney Disease

Animals, Journal Year: 2025, Volume and Issue: 15(6), P. 889 - 889

Published: March 20, 2025

This study used hair cortisol concentration (HCC) and the Feline Behavioral Assessment Research Questionnaire as indicators of chronic stress status behavioral changes in cats, respectively. Few studies have simultaneously employed both indices to examine cats with kidney disease (CKD). aimed evaluate HCC questionnaire data from control group (n = 21) those CKD 21). Additionally, we investigated correlation between living environment. For this study, samples were collected cats’ abdomens analyzed for HCC. Owners completed questionnaires provide information on their behavior, demographics, environmental factors, household characteristics over 3 months. Cats late-stage had significantly higher levels than early-stage groups. We observed different associations patterns, environments, depending stage progression. The consistency findings results, including group, suggests possibility a complex interaction progression stress.

Language: Английский

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Parents’ Reflective Functioning, Emotion Regulation, and Health: Associations with Children’s Functional Somatic Symptoms

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(2), P. 31 - 31

Published: April 3, 2025

Functional somatic symptoms (FSSs) in children—such as headaches, stomachaches, and muscle pain without clear medical explanations—pose a significant clinical challenge, often leading to repeated healthcare visits impairments daily functioning. While the role of parental psychological factors shaping children’s FSSs has been suggested, empirical evidence remains limited fragmented. This study addresses this gap by systematically examining associations between parents’ reflective functioning, emotion regulation, alexithymia, physical mental health, frequency severity FSSs. A total 339 parents children aged 6–12 completed surveys assessing their capacity understand states, regulate emotions, identify or describe feelings, well self-reported health. They also indicated whether child experienced (e.g., stomachaches) more than once per week. Results revealed that with reported significantly lower levels functioning (lower certainty, higher uncertainty), alexithymic traits, greater regulation difficulties, alongside poorer health indices. Logistic regression analyses demonstrated difficulties increased likelihood exhibiting FSSs, while emerged predictor. Furthermore, multiple linear challenges poor predicted These findings offer novel insights into how characteristics can shape symptom expression, highlighting need for family-focused interventions. By identifying addressing emotional cognitive clinicians may be able mitigate intergenerational transmission maladaptive stress responses, ultimately reducing burden children.

Language: Английский

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Molecular and metabolic effects of chronic stress on health, aging and carcinogenesis

Biopolymers and Cell, Journal Year: 2025, Volume and Issue: 41(1), P. 23 - 31

Published: April 14, 2025

Language: Английский

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Abnormal microbiota due to prenatal antibiotic as a possible risk factor for Attention-Deficit / Hyperactivity Disorder (ADHD)

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Exploring Socio-Behavioral Correlates of Metabolic and Inflammatory Risk in a University Sample Residing Along the U.S./Mexico Border: A Pilot Study Concomitantly Collecting Survey Data, Blood and Hair Samples, and Physical Measures

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 647 - 647

Published: April 20, 2025

Hispanic adults have an increased incidence of type 2 diabetes (T2D) at a younger age and diagnosis certain cancers, including liver, stomach, colorectal, which may be attributed to metabolic health. Several key health indicators, such as hemoglobin A1c (HbA1c), body mass index (BMI), waist-to-hip ratio (WHR), been linked obesity. The purpose this pilot study was explore the complex relationships between socio-behavioral factors that lead syndrome (e.g., HbA1c) chronic inflammation (interleukins) in Hispanics. Two hundred twelve participants (Mage = 43.45, SD 15.36) who identified predominantly female (72.17%) were included study. Correlational analyses revealed HbA1c positively associated with negatively several factors, overall health, quality life, physical performance, social support, mother’s education, father’s education. These findings highlight importance support parental involvement management. focused integration biological data provides powerful foundation for future research development targeted interventions.

Language: Английский

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