Carvacrol incorporation into novel controlled-release mucoadhesive systems for oral polymicrobial biofilm control DOI
Luciana Solera Sales, Aline Leite de Farias, Andréía Bagliotti Meneguin

et al.

Biofouling, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Nov. 18, 2024

The aim of this study was to evaluate carvacrol antimicrobial activity in polymicrobial biofilms using a novel controlled-release mucoadhesive systems developed from biopolymers. natural polymers gellan gum and sodium alginate were used different concentrations for the development films, tablets microparticles containing carvacrol. characterized as regard their morphological characteristics, release mucoadhesion. Furthermore, evaluated on through biomass quantification microbial viability assessment. Carvacrol profile similar; nearly 100% released within 15 min. Films showed best mucoadhesion values. Scanning Electron Microscopy images that films presented continuous smooth surface, surface with polymer web appearance. spherical shape. highest reduction, followed by tablets. findings incorporated into biofilm. Controlled-release is process little explored dentistry, being differential work, great innovative potential management dental diseases.

Language: Английский

Oral Microbiota and Inflammatory Bowel Diseases: Detection of Emerging Fungal Pathogens and Herpesvirus DOI Creative Commons
Manoel Marques Evangelista Oliveira, Letícia Campos, Fernanda Brito

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 480 - 480

Published: Feb. 15, 2025

Background/Objectives: Ulcerative colitis (UC) and Crohn’s disease (CD) are the usual clinical forms of inflammatory bowel (IBD). Changes in oral microbiota, especially presence emerging fungi herpesviruses, have been shown to worsen aspects IBD. The aim this study was screen for pathogens yeast microbiota herpesvirus IBD patients. Methods: Oral swabs seven UC or CD patients were collected. samples plated on Sabouraud Dextrose Agar subcultured CHROMagar Candida Plus. Polyphasic taxonomy applied identified using molecular tools, such as MALDI-TOF MS ITS partial sequencing. Multiplex qPCR used identify herpesvirus. Results: mean age 38.67 ± 14.06 years, 57.14% female, two had diabetes. presented with Rhodotorula mucilaginosa, orthopsilosis Kodamaea jinghongensis, while Cutaneotrichosporon dermatis, glabrata, lusitanea tropicalis. Two individuals at least one In first individual, a co-detection Herpes Simplex Virus 1 (HSV-1) C. lusitaniae observed. second co-infections Epstein–Barr virus (EBV), Human Herpesvirus 7 (HHV-7) Conclusions: We rarely described yeasts patients, highlighting need they may contribute opportunistic infections.

Language: Английский

Citations

0
Comparative study of the profile of supragingival dental plaque and tooth decay in patients with lupus erythematosus and rheumatoid arthritis DOI Creative Commons
Aida Mehdipour, Maryam Masoumi, Roohollah Fateh

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 18, 2025

Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases that present with a range of systemic oral manifestations including dental decay alterations in the microbiome profile. The purpose this study was to compare fungal bacterial profile supragingival plaque caries patients SLE RA. descriptive-cross-sectional-analytical conducted on 91 participants (31 RA, 30 lupus, control groups). Decayed, Missing, Filled teeth (DMFT) International Caries Detection Assessment System (ICDAS) indices were used investigate tooth decay. DAS-28 index assess severity SLEDAI-2 K evaluate lupus. number Streptococcus mutans, Lactobacillus spp. Candida albicans colonies evaluated using Mitis Salivarius Agar (MSA), deMan-Rogosa-Sharpe agar (MRS) Sabouraud Dextrose Chloramphenicol (SC) culture medium, respectively. Data analyzed one-way ANOVA, Kruskal -Wallis, k2, Fisher's tests, Spearman's correlation coefficient. A statistically significant relationship observed between education level (P = 0.030), mean DMFT, ICDAS, MSA SC < 0.001) type disease. RA group showed significantly higher MRS than 0.001). There positive disease (Candida albicans) 0.001, R 0.698) 0/020, 0.408) indices. Dental flora healthy group. It is recommended these pay more attention their hygiene undergo periodic examinations.

Language: Английский

Citations

0
Glycans in the oral bacteria and fungi: Shaping host-microbe interactions and human health DOI

Xiameng Ren,

Min Wang,

Jiabao Du

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136932 - 136932

Published: Oct. 30, 2024

Language: Английский

Citations

3
Impact of Malocclusions on Periodontopathogenic Bacterial Load and Progression of Periodontal Disease: A Quantitative Analysis DOI Creative Commons

Ştefan-Dimitrie Albu,

Ioana Suciu,

Cristina-Crenguța Albu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1553 - 1553

Published: July 29, 2024

(1) Periodontal disease (PD) is a globally prevalent chronic inflammatory condition, exacerbated by the dysbiosis of oral microbiota. This study aims to evaluate bacterial load specific periodontopathogenic bacteria in patients with malocclusions (MAL) compared those without. (2) Methods: Conducted at "Carol Davila" University Medicine and Pharmacy, Bucharest, Romania, this pilot involved two groups: MAL PD, PD but without MAL. We included 20 patients: 10 (9 crowding 1 an open bite) Gingival crevicular fluid was collected for DNA extraction quantified using real-time PCR, focusing on 12 across different complexity classes. (3) Results: The identified significantly higher concentrations

Language: Английский

Citations

2
Oral Mycobiome Alterations in Postmenopausal Women: Links to Inflammation, Xerostomia, and Systemic Health DOI Creative Commons
Claudia Florina Andreescu,

Andreea-Mariana Bănățeanu,

Cristina-Crenguța Albu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2569 - 2569

Published: Nov. 9, 2024

The oral mycobiome plays a critical role in maintaining and systemic health, with its composition function influenced by various physiological environmental factors. This descriptive review explores the changes among postmenopausal women, examining how aging associated inflammatory processes contribute to these alterations. These are linked an increased prevalence of xerostomia, dysbiosis, inflammation, which can negatively impact both health. We discuss hormonal fluctuations immune senescence on fungal diversity abundance, highlighting key species implicated diseases. also examines conditions medications, common further exacerbating Lastly, it highlights need for future research better understand interactions develop targeted therapeutic strategies. current literature indicates significant association between menopausal status, age-related shifts, responses, suggesting potential pathways intervention.

Language: Английский

Citations

1
DIGITAL PMMA, WHEN AND WHICH DOI Creative Commons

Andreea Mariana Banateanu,

Cristian Niky Cumpătă, Alexandru Burcea

et al.

Published: Dec. 20, 2024

Polymethyl methacrylate (PMMA) has become a cornerstone of dental prosthetics, valued for its adaptability, biocompatibility, and cost-effectiveness. In recent years, rapid advancements in material science digital manufacturing technologies, particularly CAD/CAM milling 3D printing, have driven PMMA to new levels functionality application. These innovations enhanced the material's physical properties—such as strength, aesthetic quality, wear resistance—making it suitable both temporary and, some cases, long-term restorations. This review examines evolution applications, emphasizing modifications composition, processing techniques, clinical outcomes. Topics covered include multi-layered high-impact variants, advancements, printing methods, how these developments address needs modern dentistry.

Language: Английский

Citations

1
Oral Wound Healing in Aging Population DOI Creative Commons
Claudia Florina Andreescu,

Andreea-Mariana Bănățeanu,

Oana Botoacă

et al.

Surgeries, Journal Year: 2024, Volume and Issue: 5(4), P. 956 - 969

Published: Oct. 8, 2024

Background: Oral wound healing in the aging population is a multifaceted issue requiring comprehensive approach, considering physiological changes that come with and frequent presence of comorbidities. Methods: This descriptive review summarizes factors influencing oral patients, including age-related changes, hormonal modifications, multimorbidities, polypharmacy, oralome alterations, nutritional status. Results: The encounters numerous challenges due to intrinsic factors, such as biological extrinsic medication use lifestyle. Conclusion: Understanding these their combined impact essential for effective clinical management improved outcomes older adults.

Language: Английский

Citations

0
Carvacrol incorporation into novel controlled-release mucoadhesive systems for oral polymicrobial biofilm control DOI
Luciana Solera Sales, Aline Leite de Farias, Andréía Bagliotti Meneguin

et al.

Biofouling, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Nov. 18, 2024

The aim of this study was to evaluate carvacrol antimicrobial activity in polymicrobial biofilms using a novel controlled-release mucoadhesive systems developed from biopolymers. natural polymers gellan gum and sodium alginate were used different concentrations for the development films, tablets microparticles containing carvacrol. characterized as regard their morphological characteristics, release mucoadhesion. Furthermore, evaluated on through biomass quantification microbial viability assessment. Carvacrol profile similar; nearly 100% released within 15 min. Films showed best mucoadhesion values. Scanning Electron Microscopy images that films presented continuous smooth surface, surface with polymer web appearance. spherical shape. highest reduction, followed by tablets. findings incorporated into biofilm. Controlled-release is process little explored dentistry, being differential work, great innovative potential management dental diseases.

Language: Английский

Citations

0