Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 31, 2024
Magnetic nanoparticles (MNPs) are of great interest for their wide applications in biomedical applications, such as bioimaging, antitumoral therapies, regenerative medicine, and drug delivery. The work aimed to obtain biocompatible magnetite coated with amino acids the general formula Fe
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 485, P. 215136 - 215136
Published: March 27, 2023
Language: Английский
Citations
68
Particle & Particle Systems Characterization, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
Abstract The synthesis of magnetite nanoparticles (Fe₃O₄ NPs) has gained significant interest due to their broad applications, particularly in biomedicine and environmental purification. In this study, Fe₃O₄ NPs are synthesized using a novel chemical co‐precipitation method, yielding with excellent characteristics such as saturation magnetization 41.42 emu g −1 , coercivity less than 4 Oe, remanence below 0.4 demonstrating superparamagnetic‐like properties. particles achieved an average size 11 nm displayed robust colloidal stability aqueous suspension for ≈30 days. Additionally, chitosan‐coated (Fe₃O₄‐CS) prepared, which maintained similar magnetic properties slightly lower 38.35 the nonmagnetic CS layer. To assess biomedical applicability these NPs, effects on model proteins human serum albumin lysozyme examined. Circular dichroism studies revealed only slight decreases α‐helix content indicating minimal alterations secondary structure. Moreover, fluorescence indicated local changes protein tertiary structures without disruption. This research highlights potential Fe₃O₄‐CS applications drug delivery controlled release systems stability, biocompatibility, unique
Language: Английский
Citations
2
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1872 - 1872
Published: July 3, 2023
With the predicted rise in incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures imaging and drug delivery systems they possess unique properties. Moreover, nanomaterials functionalized with other compounds can lead to multicomponent innovative structures synergetic performance. The incorporation chemotherapeutic drugs or RNA represents a alternative that increase efficiency reduce side effects anticancer therapy. This review presents critical overview recent literature concerning advancements field used delivery, focus on their classification, characteristics, synthesis functionalization methods, limitations, examples incorporating chemotherapeutics RNA.
Language: Английский
Citations
38
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2406 - 2406
Published: Sept. 30, 2023
The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads an increase in potency radiation therapy and allows for decreasing dose concomitant side effects. Radiosensitization by metal oxide nanoparticles widely discussed, but range mechanisms studied not sufficiently codified often does reflect ability nanocarriers have a specific impact on cells. This review focused magnetic iron while they occupied special niche among prospective radiosensitizers due unique physicochemical characteristics reactivity. We collected data about possible molecular underlying radiosensitizing effects (IONPs) approaches their therapeutic efficacy variable modifications.
Language: Английский
Citations
25
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 771 - 771
Published: Feb. 26, 2023
A magnetic nanocomposite (MNC) is an integrated nanoplatform that combines a set of functions two types materials. successful combination can give rise to completely new material with unique physical, chemical, and biological properties. The core MNC provides the possibility resonance or particle imaging, field-influenced targeted delivery, hyperthermia, other outstanding applications. Recently, gained attention for external field-guided specific delivery cancer tissue. Further, drug loading enhancement, construction stability, biocompatibility improvement may lead high progress in area. Herein, novel method nanoscale Fe3O4@CaCO3 composites synthesis was proposed. For procedure, oleic acid-modified Fe3O4 nanoparticles were coated porous CaCO3 using ion coprecipitation technique. PEG-2000, Tween 20, DMEM cell media successfully used as stabilization agent template synthesis. Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS) data MNC's characterization. To improve properties, concentration varied, yielding optimal size, polydispersity, aggregation ability. resulting had size 135 nm narrow distributions, which suitable biomedical stability experiment various pH, media, fetal bovine serum also evaluated. showed low cytotoxicity biocompatibility. An excellent anticancer doxorubicin (DOX) up 1900 µg/mg (DOX/MNC) demonstrated. Fe3O4@CaCO3/DOX displayed at neutral pH efficient acid-responsive release. series DOX-loaded MNCs indicated effective inhibition Hela MCF-7 lines, IC 50 values calculated. Moreover, 1.5 μg sufficient inhibit 50% cells, shows prospect treatment. experiments human albumin solution release due formation protein corona. presented "pitfalls" nanocomposites provided step-by-step guidance on efficient, smart, nanoconstruction fabrication. Thus, exhibits good performance treatment
Language: Английский
Citations
24
Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102045 - 102045
Published: Jan. 1, 2025
Language: Английский
Citations
1
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 285 - 285
Published: Feb. 13, 2025
Cancer continues to be a prominent fatal health issue worldwide, driving the urgent need for more effective treatment strategies. The pressing demand has sparked significant interest in development of advanced drug delivery systems chemotherapeutics. advent nanotechnology offers groundbreaking approach, presenting promising pathway revolutionize cancer and improve patient outcomes. Nanomedicine-based have demonstrated capability improving pharmacokinetic properties accumulation chemotherapeutic agents sites while minimizing adverse side effects. Despite these advantages, most NDDSs exhibit only limited improvement during clinical trials. recent magnetic nanoparticles (MNPs) biomedical applications revealed potential opportunity further enhance performance NDDSs. MNPs can utilized increase targeting capabilities NDDSs, controlled release agents, weaken chemoresistance tumors with hyperthermia. In this review, we will explore advancements research oncology applications, how their augment when complexed them emphasize challenges safety concerns incorporating into treatment.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4480 - 4480
Published: Feb. 24, 2023
Nanoplatforms applied for the loading of anticancer drugs is a cutting-edge approach drug delivery to tumors and reduction toxic effects on healthy cells. In this study, we describe synthesis compare sorption properties four types potential doxorubicin-carriers, in which iron oxide nanoparticles (IONs) are functionalized with cationic (polyethylenimine, PEI), anionic (polystyrenesulfonate, PSS), nonionic (dextran) polymers, as well porous carbon. The IONs thoroughly characterized by X-ray diffraction, IR spectroscopy, high resolution TEM (HRTEM), SEM, magnetic susceptibility, zeta-potential measurements pH range 3–10. degree doxorubicin at 7.4, desorption 5.0, distinctive cancerous tumor environment, measured. Particles modified PEI were shown exhibit highest capacity, while greatest release 5 (up 30%) occurs from surface magnetite decorated PSS. Such slow would imply prolonged tumor-inhibiting action affected tissue or organ. Assessment toxicity (using Neuro2A cell line) PEI- PSS-modified showed no negative effect. conclusion, preliminary evaluation coated PSS rate blood clotting was carried out. results obtained can be taken into account when developing new platforms.
Language: Английский
Citations
23
Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2343 - 2343
Published: March 3, 2023
In the emerging field of nanomedicine, nanoparticles have been widely considered as drug carriers and are now used in various clinically approved products. Therefore, this study, we synthesized superparamagnetic iron-oxide (SPIONs) via green chemistry, SPIONs were further coated with tamoxifen-conjugated bovine serum albumin (BSA-SPIONs-TMX). The BSA-SPIONs-TMX within nanometric hydrodynamic size (117 ± 4 nm), a small poly dispersity index (0.28 0.02) zeta potential -30.2 0.09 mV. FTIR, DSC, X-RD, elemental analysis confirmed that successfully prepared. saturation magnetization (Ms) was found to be ~8.31 emu/g, indicating possess properties for theragnostic applications. addition, efficiently internalized into breast cancer cell lines (MCF-7 T47D) effective reducing proliferation cells, IC50 values 4.97 0.42 μM 6.29 0.21 MCF-7 T47D respectively. Furthermore, an acute toxicity study on rats these safe use delivery systems. conclusion, may also diagnostic
Language: Английский
Citations
22
Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 156, P. 111291 - 111291
Published: Aug. 22, 2023
Language: Английский
Citations
20