This
review
paper
highlights
the
current
toxicological
aspects
of
magnetic
nanomaterials
in
field
medicine
and
environment,
conducted
through
a
comprehensive
literature
review.
The
main
goal
was
to
investigate
analyze
key
challenges
identified
that
impede
effective
utilization
these
systems,
particularly
focusing
on
iron
oxide
(Fe3O4)
nanoparticles.
We
aimed
factors
influence
their
intended
applications.
sought
understand
how
characteristics
produced
NPs
could
be
enhanced
improve
biocompatibility
compared
existing
samples
literature.
Additionally,
we
examined
morphological
directly
linked
physicochemical
potential
implications
for
toxicology
ecotoxicology.
Furthermore,
evaluated
regulatory
impact
nanostructured
materials.
Therefore,
initial
aspect
this
delved
into
historical
evolution
nanoparticles,
investigating
significant
milestones
have
influenced
exploration
technology.
discoveries,
influencing
choice
synthesis
methods,
most
prevalent
approaches
surface
functionalization
employed
by
scientists
materials
possessing
superparamagnetic
characteristics,
such
as
oxide.
second
focused
survey-based
global
regulation
progress
concerning
nanoparticles
throughout
years.
encountered
establishing
safety
criteria
diverse
applications
under
investigation.
encompassed
an
assessment
impacts
both
human
health
environment.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1650 - 1650
Published: June 3, 2023
The
ambition
to
combat
the
issues
affecting
environment
and
human
health
triggers
development
of
biosynthesis
that
incorporates
production
natural
compounds
by
living
organisms
via
eco-friendly
nano
assembly.
Biosynthesized
nanoparticles
(NPs)
have
various
pharmaceutical
applications,
such
as
tumoricidal,
anti-inflammatory,
antimicrobials,
antiviral,
etc.
When
combined,
bio-nanotechnology
drug
delivery
give
rise
pharmaceutics
with
site-specific
biomedical
applications.
In
this
review,
we
attempted
summarize
in
brief
types
renewable
biological
systems
used
for
metallic
metal
oxide
NPs
vital
contribution
biogenic
carriers
simultaneously.
biosystem
assembly
further
affects
morphology,
size,
shape,
structure
produced
nanomaterial.
toxicity
NPs,
because
their
pharmacokinetic
behavior
vitro
vivo,
is
also
discussed,
together
some
recent
achievements
towards
enhanced
biocompatibility,
bioavailability,
reduced
side
effects.
Because
large
biodiversity,
potential
application
extracts
nanomedicine
yet
be
explored.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(8), P. 1108 - 1108
Published: Aug. 4, 2023
Resistance
to
isoniazid
(INH)
is
common
and
increases
the
possibility
of
acquiring
multidrug-resistant
tuberculosis.
For
this
study,
isoniazid-loaded
nanostructured
lipid
carriers
(INH-NLCs)
were
developed
effectively
functionalized
with
mannose
(Man)
enhance
residence
time
drug
within
lungs
via
specific
delivery
increase
therapeutic
efficacy
formulation.
The
mannose-functionalized
carrier
(Man-INH-NLC)
formulation
was
evaluated
respect
various
parameters,
namely,
encapsulation
efficiency
(EE),
loading
(DL),
average
particle
size
(PS),
zeta
potential
(ZP),
polydispersity
index
(PDI),
in
vitro
release
(DR),
kinetics.
inhalation
behavior
after
nebulization
investigated
using
an
Andersen
cascade
impactor
estimation
mass
median
aerosolized
diameter
(MMAD)
geometric
aerodynamic
(GAD)
subsequently
found
be
suitable
for
effective
lung
delivery.
An
vivo
pharmacokinetic
study
carried
out
a
guinea
pig
animal
model,
it
demonstrated
that
Man-INH-NLC
has
longer
improved
pharmacokinetics
when
compared
unfunctionalized
INH-NLC,
indicating
enhanced
Histopathological
analysis
led
us
determine
extent
tissue
damage
more
severe
case
pure
solution
nebulization.
Thus,
safe,
forming
sound
basis
enhancing
management
treatment
pulmonary
Drug Development and Industrial Pharmacy,
Journal Year:
2024,
Volume and Issue:
50(6), P. 561 - 575
Published: June 2, 2024
Breast
cancer
(BC)
is
the
most
common
malignancy
in
women
globally.
Significant
progress
has
been
made
developing
structural
nanoparticles
(NPs)
and
formulations
for
targeted
smart
drug
delivery
(SDD)
of
pharmaceuticals,
improving
precision
tumor
cell
targeting
therapy.
Nanotechnology,
Journal Year:
2024,
Volume and Issue:
36(4), P. 042003 - 042003
Published: Oct. 12, 2024
Abstract
Magnetic
nanoparticles
(MNPs)
represent
a
class
of
small
particles
typically
with
diameters
ranging
from
1
to
100
nanometers.
These
are
composed
magnetic
materials
such
as
iron,
cobalt,
nickel,
or
their
alloys.
The
nanoscale
size
MNPs
gives
them
unique
physicochemical
(physical
and
chemical)
properties
not
found
in
bulk
counterparts.
Their
versatile
nature
behavior
make
valuable
wide
range
scientific,
medical,
technological
fields.
Over
the
past
decade,
there
has
been
significant
surge
MNP-based
applications
spanning
biomedical
uses,
environmental
remediation,
data
storage,
energy
catalysis.
Given
size,
can
be
manipulated
guided
using
external
This
characteristic
is
harnessed
applications,
where
these
directed
specific
targets
body
for
imaging,
drug
delivery,
hyperthermia
treatment.
Herein,
this
roadmap
offers
an
overview
current
status,
challenges,
advancements
various
facets
MNPs.
It
covers
properties,
synthesis,
functionalization,
characterization,
sample
enrichment,
bioassays,
hyperthermia,
neuromodulation,
tissue
engineering,
drug/gene
delivery.
However,
increasingly
explored
vivo
concerns
have
emerged
regarding
cytotoxicity,
cellular
uptake,
degradation,
prompting
attention
both
researchers
clinicians.
aims
provide
comprehensive
perspective
on
evolving
landscape
MNP
research.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(33), P. 8153 - 8166
Published: Jan. 1, 2024
Development
of
a
functional
protein-templated
nanocomposite
containing
luminescent
Au–Ag
nanoclusters
and
SPION,
successfully
applied
as
biocompatible
contrast
agent
in
living
mice.
