On effect of chloroform on electrical activity of proteinoids DOI Open Access
Panagiotis Mougkogiannis, Andrew Adamatzky

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 30, 2023

Abstract Proteinoids, or thermal proteins, produce hollow microspheres in aqueous solution. Ensembles of the endogenous spikes electrical activity, similar to that neurons. To make a first step towards evaluation mechanisms such behaviour we decided expose proteinoids chloroform. We found while chloroform does not inhibit oscillations it causes substantial changes patterns activity. Namely, incremental exposure strongly affect proteinoid microsphere activity across multiple metrics. As levels rise, spike potential drops from 0.9 mV under control conditions 0.1 at 25 mg/mL. This progressive decrease suggests suppresses The time between spikes, interspike period, follows pattern. Minimal change average inter-spike higher exposures do. It 23.2 min experiments 3.8 mg/mL chloroform, indicating increased frequency These findings might leads deeper understanding and their application domain bioelectronics.

Language: Английский

On fault-tolerant Boolean functions in proteinoids–ZnO colloids DOI Creative Commons
Noushin Raeisi Kheirabadi, Panagiotis Mougkogiannis, Raphael Fortulan

et al.

Journal of Materials Science Materials in Electronics, Journal Year: 2025, Volume and Issue: 36(4)

Published: Feb. 1, 2025

Language: Английский

Citations

1

Living Kombucha Electronics with Proteinoids DOI Creative Commons
Anna Nikolaidou, Panagiotis Mougkogiannis, Andrew Adamatzky

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Language: Английский

Citations

0

Reservoir Computing with Colloidal Mixtures of ZnO and Proteinoids DOI Creative Commons
Raphael Fortulan, Noushin Raeisi Kheirabadi, Panagiotis Mougkogiannis

et al.

Published: Dec. 14, 2023

Liquid computers use incompressible fluids for computational processes. Here we present experimental laboratory prototypes of liquid using colloids composed zinc oxide (ZnO) nanoparticles and microspheres containing thermal proteins (proteinoids). The choice proteinoids is based on their distinctive neuron-like electrical behaviour similarity to protocells. In addition, ZnO are chosen non-trivial properties. Our research demonstrates the successful extraction 2-, 4- 8-bit logic functions in proteinoid colloids. analysis shows that each material has a distinct set functions, complexity expressions directly related mixture. These findings provide basis development future hybris devices capable general purpose computing.

Language: Английский

Citations

5

The Effects of Omeprazole on the Neuron-like Spiking of the Electrical Potential of Proteinoid Microspheres DOI Creative Commons
Panagiotis Mougkogiannis, Andrew Adamatzky

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4700 - 4700

Published: Oct. 4, 2024

This study examines a new approach to hybrid neuromorphic devices by studying the impact of omeprazole–proteinoid complexes on Izhikevich neuron models. We investigate influence these metabolic structures five specific patterns neuronal firing: accommodation, chattering, triggered spiking, phasic and tonic spiking. By combining omeprazole, proton pump inhibitor, with proteinoids, we create unique substrate that interfaces The model is used because it computationally efficient can accurately simulate various behaviours cortical neurons. results our simulations show have ability affect dynamics in different ways. suggests they could be as adjustable components bio-inspired computer systems. noticed notable alteration frequency spikes, bursts, rates adaptation, especially chattering spiking behaviours. findings indicate potential serve adaptable elements systems, presenting novel opportunities for information processing computation origins neurobiological principles. makes valuable contribution expanding field biochemical establishes basis development bio-synthetic computational

Language: Английский

Citations

1

Kombucha–Proteinoid Crystal Bioelectric Circuits DOI Creative Commons
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(45), P. 45386 - 45401

Published: Oct. 28, 2024

We propose "kombucha–proteinoid crystal bioelectric circuits" as a sustainable bio-computing platform. These circuits are hybrid biological-inorganic devices that utilize growth dynamics the physical substrate to convert information. Microfluidic prototypes couple custom-synthesized thermal proteinoids within kombucha cellulose matrices and metastable calcium carbonate solutions. This bio-mineral configuration examines if precision modulation of rates could instantiate reconfigurable logic gates for unconventional computing applications. Programming organic acid secretions allows adjustment biotic-mineral polarity, thereby establishing microbial-synthetic pairings consistently regulate rate calcite deposition. By coordinating intrinsic physicochemical phenomena, accrued mineral densities literally crystallize additive/multiplicative operations via Boolean AND/OR logics. An additional way generate structured logics similar neural assemblies is by chaining modular crystallizer units. Proteinoid-guided crystallization may prove be viable material platform computing-green, self-organizing, scalable architectures grown directly from solution-pending definitive affirmation proof-of-concept.

Language: Английский

Citations

1

On effect of chloroform on electrical activity of proteinoids DOI Open Access
Panagiotis Mougkogiannis, Andrew Adamatzky

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 30, 2023

Abstract Proteinoids, or thermal proteins, produce hollow microspheres in aqueous solution. Ensembles of the endogenous spikes electrical activity, similar to that neurons. To make a first step towards evaluation mechanisms such behaviour we decided expose proteinoids chloroform. We found while chloroform does not inhibit oscillations it causes substantial changes patterns activity. Namely, incremental exposure strongly affect proteinoid microsphere activity across multiple metrics. As levels rise, spike potential drops from 0.9 mV under control conditions 0.1 at 25 mg/mL. This progressive decrease suggests suppresses The time between spikes, interspike period, follows pattern. Minimal change average inter-spike higher exposures do. It 23.2 min experiments 3.8 mg/mL chloroform, indicating increased frequency These findings might leads deeper understanding and their application domain bioelectronics.

Language: Английский

Citations

0