Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101863 - 101863
Published: Nov. 1, 2024
Language: Английский
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155174 - 155174
Published: Jan. 26, 2024
Breast cancer remains a major global health challenge. Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing less-than-ideal patient outcomes. Central progression breast are epigenetic aberrations, which significantly contribute resistance emergence stem cell traits. These include alterations in DNA methylation, histone modifications, expression non-coding RNAs. Understanding these changes crucial for developing advanced management strategies despite their complexity. Investigating modifications offers potential novel diagnostic markers, more accurate prognostic indicators, identification reliable predictors treatment response. This could lead development new targeted therapies. However, this requires sustained, focused research efforts navigate challenges understanding carcinogenesis underpinnings. A deeper mechanisms can revolutionize personalized medicine. significant improvements care, including early detection, precise disease stratification, effective options.
Language: Английский
Citations
17
Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 234 - 234
Published: Jan. 13, 2025
The complex signaling network within the breast tumor microenvironment is crucial for its growth, metastasis, angiogenesis, therapy escape, stem cell maintenance, and immunomodulation. An array of secretory factors their receptors activate downstream cascades regulating cancer progression metastasis. Among various pathways, EGFR, ER, Notch, Hedgehog pathways have recently been identified as in terms proliferation, survival, differentiation, maintenance CSCs, failure. These mediate such MAPK, including MEK/ERK that promote common pro-oncogenic signaling, whereas dysregulation PI3K/Akt, Wnt/β-catenin, JAK/STAT activates key oncogenic events drug resistance, CSC enrichment, metabolic reprogramming. Additionally, these orchestrate an intricate interplay between stromal cells, immune cells. Metabolic reprogramming adaptations contribute to aggressive are unresponsive therapy. Herein, recent insights into novel operating TME aid advancement emphasized current developments practices targeting enhance treatment efficacy reviewed.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1155 - 1155
Published: May 25, 2023
The pineal gland-derived indoleamine hormone, melatonin, regulates multiple cellular processes, ranging from chronobiology, proliferation, apoptosis, and oxidative damage to pigmentation, immune regulation, mitochondrial metabolism. While melatonin is best known as a master regulator of the circadian rhythm, previous studies also have revealed connections between cycle disruption genomic instability, including epigenetic changes in pattern DNA methylation. For example, secretion associated with differential gene methylation night shift workers regulation during embryonic development, there accumulating evidence that can modify Since latter one impacts cancer initiation, also, non-malignant diseases targeting has become novel intervention target clinical therapy, this review discusses potential role an under-investigated candidate regulator, namely by modulating via mRNA protein expression methyltransferases (DNMTs) ten-eleven translocation (TET) proteins. Furthermore, since may impact pattern, authors suggest its possible use combination therapy drugs new anticancer strategy.
Language: Английский
Citations
21
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12690 - 12690
Published: Aug. 11, 2023
Breast cancer (BC) has yielded approximately 2.26 million new cases and caused nearly 685,000 deaths worldwide in the last two years, making it most common diagnosed type world. BC is an intricate ecosystem formed by both tumor microenvironment malignant cells, its heterogeneity impacts response to treatment. Biomedical research entered era of massive omics data thanks high-throughput sequencing revolution, quick progress widespread adoption. These technologies—liquid biopsy, transcriptomics, epigenomics, proteomics, metabolomics, pharmaco-omics artificial intelligence imaging—could help researchers clinicians better understand formation evolution BC. This review focuses on findings recent multi-omics-based that been applied research, with introduction every technique their applications for different phenotypes, biomarkers, target therapies, diagnosis, treatment prognosis, provide a comprehensive overview possibilities research.
Language: Английский
Citations
19
Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2164 - 2164
Published: June 7, 2024
Breast cancer, the most frequent malignancy in women worldwide, is a molecularly and clinically very heterogeneous disease. Triple-negative breast cancer defined by absence of hormone receptor growth factor ERBB2/HER2 expression. It characterized more aggressive course disease shortage effective therapeutic approaches. Hallmarks cells are not only genetic alterations, but also epigenetic aberrations. The studied best understood alterations methylation DNA base cytosine covalent modification histone proteins. reversibility these modifications make them attractive targets for intervention, as documented numerous ongoing clinical trials. Epidrugs, targeting modifications, might offer new options treating triple-negative cancer. Currently, promising combination therapies which epidrug increases efficiency immuncheckpoint inhibitors. This review focusses exclusively on modifications. In reviewing knowledge about especially focus explaining concepts raising awareness what yet known has to be clarified future.
Language: Английский
Citations
6
FEBS Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 16, 2024
Cancer remains a significant global health concern. Breast cancer is multifaceted and prevalent disease influenced by several factors, among which estrogen receptors (ERs) the extracellular matrix (ECM) play pivotal roles. ERs, encompassing ERα ERβ, exert diversity on tumor behavior, cell signaling, invasion, metastatic potential, thus guiding breast prognosis. Understanding multifunctional connections between ERs ECM that mediate dynamics of microenvironment vital for unraveling complexity pathobiology identifying novel therapeutic targets. This critical review delves into intricate nature emphasizing their structural isoforms consequential impact outcomes. A detailed examination ER‐mediated signaling pathways reveals how differential expression ERβ influence behavior. The functional ERs‐matrix interactions emerge as factor in modulating epigenetic mechanisms cells, orchestrating changes cellular phenotype patterns modulators. Specifically, are shown to regulate cascades, while effects components activity highlight bidirectional regulatory axis. also highlighted, illustrating distinct contribution ECM‐mediated responses. underscores complex interplay ERα/β ECM, shedding light onto potential strategies targeting these improve management.
Language: Английский
Citations
6
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(8)
Published: Aug. 19, 2024
Breast cancer, a heterogeneous and intricate disease, ranks among the leading causes of mortality in women. Restricted therapeutic choices, drug resistance, recurrence, metastasis are predominant conditions that lead to mortality. Accumulating evidence has shown breast cancer initiation progression happen through multifaceted process involves numerous genetic epigenetic alterations. The modulation gene expression modifications, encompassing DNA methylation, histone alterations, non-coding RNA regulation, emerged as fascinating field represents new avenue for therapy. This review emphasizes various aberrant regulations implicated onset advancement cancer. critical modifications closely associated with estrogen signaling, epithelial-to-mesenchymal transition (EMT), stemness, resistance have been discussed extensively. Moreover, it highlights current epi-drugs, including modifying agents, acetyltransferase inhibitors, deacetylase methyltransferase demethyltransferase inhibitors used treatment. Nonetheless, we described investigations pertaining combination therapy employing epi-drugs future challenges.
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13518 - 13518
Published: Dec. 17, 2024
Triple-negative breast cancer (TNBC) represents roughly one-sixth of all patients, but accounts for 30–40% deaths. Due to the lack typical biomarkers exploited clinically cancer, it remains very difficult treat. Moreover, its intrinsic high heterogeneity and proneness become resistant drugs administered makes treatment management challenging oncologists. Herein, we outline different therapies used currently TNBC list ongoing clinical trials provide an overview most recent therapeutic landscape. In addition, highlight emerging in preclinical stage that hold promise, such as epigenetic modulators, CRISPR, miniproteins, radioconjugates, vaccines, PROTACs. navigate through existing limitations challenges which hamper development new more effective treatments TNBC. Lastly, point directions may revolutionize future therapy
Language: Английский
Citations
4
Cancers, Journal Year: 2024, Volume and Issue: 16(1), P. 209 - 209
Published: Jan. 1, 2024
Background/Aim: Triple negative breast cancer belongs to the most aggressive forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit significant role in genesis and progression. In this study, we aimed at assessing clinical importance HDAC-2 triple cancer. Materials Methods: A total 138 specimens were examined on an immunohistochemical basis. statistical analysis was performed order examine association between survival clinicopathological features patients. Results: Increased expression observed every fourth case with positive staining, whereas only 12 out 98 non-triple samples showed high expression. overexpression correlated prolonged overall (OS) disease-free (DFS) Conclusions: High levels seem positively influence patient survival, disease stage recurrence.
Language: Английский
Citations
3
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 207 - 207
Published: Feb. 3, 2025
Breast cancer is the most common malignancy affecting women, manifesting as a heterogeneous disease with diverse molecular characteristics and clinical presentations. Recent studies have elucidated role of epigenetic modifications in pathogenesis breast cancer, including drug resistance efflux characteristics, offering potential new diagnostic prognostic markers, treatment efficacy predictors, therapeutic agents. Key include DNA cytosine methylation covalent modification histone proteins. Unlike genetic mutations, reprogramming landscape epigenome promising targeted therapy for reversal resistance. Epidrugs, which target modifications, can provide novel options by reversing acquired to treatment. Currently, approach involves combination therapies consisting epidrugs immune checkpoint inhibitors. This review examines aberrant regulation initiation progression, focusing on related estrogen signaling, resistance, epithelial–mesenchymal transition (EMT). It existing drugs treating agents that modify DNA, inhibitors acetyltransferases, deacetylases, methyltransferases, demethyltransferases. also delves into ongoing combining other addresses upcoming obstacles this field.
Language: Английский
Citations
0