Stability and adhesion properties of Lacticaseibacillus rhamnosus GG embedded in milk protein cryogels: Influence of plant seed gum inclusion

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 151, P. 109867 - 109867

Published: Feb. 9, 2024

This work reports on the influence of plant seed gum (PSG) from alfalfa (Medicago sativa L.) and flaxseed (Linum usitatissimum L.), cryogels based sodium caseinate (NaCas), whey protein isolate (WPI), their combined mixture in embedding probiotic Lacticaseibacillus rhamnosus GG (LGG). A significant preservation LGG cell viability was achieved during xero-structuration process. Among materials tested, standout, most effectively preserving LGG's biological activity across varying temperature humidity conditions. Elevated storage relative conditions accelerated inactivation rates, especially case WPI (in presence or absence PSG), which primarily attributed to increased metabolic due changes xero-scaffolds' physical state. Moreover, specific type used played a pivotal role determining survival rates simulated gastrointestinal digestion processes. In adhesion tests using Caco-2/HT-29 co-culture model, showed highest found NaCas. Interestingly, except for NaCas, adding PSG augmented bioadhesion capabilities, with showing enhancement adhesin-mucin interactions. The research also underscored release bioactive peptides, displayed range health benefits including antimicrobial antioxidant properties.

Language: Английский

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Revolutionizing lung health: Exploring the latest breakthroughs and future prospects of synbiotic nanostructures in lung diseases

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 395, P. 111009 - 111009

Published: April 17, 2024

The escalating prevalence of lung diseases underscores the need for innovative therapies. Dysbiosis in human body microbiome has emerged as a significant factor these diseases, indicating potential role synbiotics restoring microbial equilibrium. However, effective delivery to target site remains challenging. Here, we aim explore suitable nanoparticles encapsulating tailored applications diseases. Nanoencapsulation prominent strategy address challenges this context. Through comprehensive review, assess facilitating synbiotic and their structural adaptability purpose. Our review reveals that such nanocellulose, starch, chitosan exhibit high encapsulation. These offer flexibility structure design synthesis, making them promising candidates addressing Furthermore, our analysis highlights synbiotics, when compared probiotics alone, demonstrate superior anti-inflammatory, antioxidant, antibacterial anticancer activities. This nanoparticle-encapsulated targeted therapeutic approach contributing valuable insights into nanomedicine revolutionizing treatment strategies respiratory conditions, ultimately paving way future advancements field.

Language: Английский

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Comprehensive insights into chitosan hydrogels: from crosslinking and characterization to immunomodulation, microbiome interactions and biomedical uses

Biomass Conversion and Biorefinery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Language: Английский

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Biological platforms for the production of antimicrobial peptides: Bacterial, yeast, and cell-free systems

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 131 - 163

Published: Jan. 1, 2025

Language: Английский

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A comprehensive review of mathematical modeling in probiotic microencapsulation

Food Engineering Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

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Nanobiotechnology Unveils the Power of Probiotics: A Comprehensive Review on the Synergistic Role of Probiotics and Advanced Nanotechnology in Enhancing Geriatric Health.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

The geriatric population, comprising ages 65 and above, encounters distinct health obstacles because of physiological changes heightened vulnerability to diseases. New technologies are being investigated tackle the intricate requirements this population. Recent advancements in probiotics nanotechnology offer promising strategies enhance by improving nutrient absorption, modulating gut microbiota, delivering targeted therapeutic agents. Probiotics play a crucial role maintaining homeostasis, reducing inflammation, supporting metabolic functions. However, challenges such as limited viability efficacy harsh gastrointestinal conditions hinder their potential. Advanced can overcome these constraints enhancing through nano-encapsulation, controlled delivery, improvement bioavailability. This review explores synergistic potential advanced addressing age-related concerns. It highlights key developments probiotic formulations, nano-based delivery systems, combined impact on health, immunity, neuroprotection. convergence represents novel transformative approach promoting healthy aging, paving way for innovative interventions.

Language: Английский

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The Utilization of Biopolymer Hydrogels to Encapsulate and Protect Probiotics in Foods

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Electrostatically assembled maghemite nanoparticles-Lactobacillus plantarum: A novel hybrid for enhanced antioxidant, antimicrobial, and antibiofilm efficacy

Bioresource Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132538 - 132538

Published: April 1, 2025

Language: Английский

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Translational strategies for oral delivery of faecal microbiota transplantation

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 335077

Published: April 29, 2025

Faecal microbiota transplantation (FMT) has emerged as a transformative therapy for Clostridioides difficile infections and shows promise various GI systemic diseases. However, the poor patient acceptability accessibility of ‘conventional’ FMT, typically administered via colonoscopies or enemas, hinders its widespread clinical adoption, particularly chronic conditions. Oral administration FMT (OralFMT) overcomes these limitations, yet faces distinct challenges, including significant capsule burden, palatability concerns microbial viability during gastric transit. This review provides comprehensive analysis emerging strategies that aim to advance OralFMT by: (1) refining processing technologies (eg, lyophilisation) enable manufacturing low-volume formulations reducing burden (2) developing delivery improve organoleptic safeguard targeted colonic release. These advancements present opportunities expand therapeutic scope, beyond C. infections, towards conditions requiring frequent dosing regimens. While this primarily focuses on optimising delivery, it is important contextualise within broader shift defined consortia. Live biotherapeutic products (LBPs) offer an alternative approach, interplay between LBPs in practice remains unresolved. We postulate continued innovation multidisciplinary approach can further increase efficacy scalability by enabling disease site targeting, co-delivery compounds overcoming colonisation resistance. Realising goals positions cornerstone personalised care across range diseases rooted microbiome health.

Language: Английский

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What We Know About the Actual Role of Traditional Probiotics in Health and Disease

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: 16(5), P. 1836 - 1856

Published: May 3, 2024

Language: Английский

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