International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144475 - 144475
Published: May 1, 2025
Language: Английский
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686
Published: Feb. 4, 2025
Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.
Language: Английский
Citations
5
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101711 - 101711
Published: March 27, 2025
Developing and utilizing effective local antimicrobial agents can help treat periodontitis while minimizing the risks associated with systemic antibiotic use. Recent studies have shown that mucosal adhesion properties of hydrogels play a potential role in treatment periodontitis. The hydrogel improve contact retention time drugs periodontal pocket. Through mucosa, it interacts mucin coating surface epithelium teeth to form specific interface force. exhibits strong (adhesion strength: 5-6 N/cm2) prolonged pockets (≥6 h), enabling sustained drug release through dynamic sol-gel transitions triggered by pH reactive oxygen species (ROS). This design overcomes limitations poor mechanical stability conventional formulations. balance oral microbiota plays an important maintaining health. Probiotics, colonizing cavity, transform infected site from environment rich inflammatory cytokines more benign environment, inhibit harmful pathogenic microorganisms, contribute overall Microenvironment sensitive perform sol gel transformation situ, accurately control when exposed various stimuli (such as temperature change, light, species, etc.). Oral probiotics anti-inflammatory are encapsulated proliferation pathogens planting mouth producing metabolites, effectively preventing treating diseases.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135893 - 135893
Published: Sept. 1, 2024
Language: Английский
Citations
8
Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4360 - 4360
Published: Sept. 13, 2024
Carboxymethyl chitosan (CMCS) hydrogels have been investigated in biomedical research because of their versatile properties that make them suitable for various medical applications. Key are especially valuable use include biocompatibility, tailored solid-like mechanical characteristics, biodegradability, antibacterial activity, moisture retention, and pH stimuli-sensitive swelling. These features offer advantages such as enhanced healing, promotion granulation tissue formation, facilitation neutrophil migration. As a result, CMCS favorable materials applications biopharmaceuticals, drug delivery systems, wound engineering, more. Understanding the interactions between biological with focus on influence cellular behavior, is crucial leveraging versatility. Because constantly growing interest its derivative applications, present review aims to provide updated insights into potential based recent findings. Additionally, we comprehensively elucidated mechanisms underlying actions these settings. In summary, this paper recapitulates data gathered from current literature, offering perspectives further development utilization carboxymethyl contexts.
Language: Английский
Citations
7
Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101236 - 101236
Published: June 19, 2024
Language: Английский
Citations
6
Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1017 - 1017
Published: Feb. 22, 2025
Neurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery central nervous system. This review investigates applications various biopolymers in neuroprotection and their potential role treating neurodegeneration. We a critical analysis natural synthetic biopolymers, focusing primarily on chitosan, fish collagen/gelatin, alginate as key agents. The examines fundamental mechanisms brain development neurodegeneration, establishing framework for understanding how these interact with neural tissues. By analyzing recent experimental studies, we evaluate effectiveness different biopolymer-based systems crossing blood-brain barrier subsequent neuroprotective effects. Additionally, promising materials, including lignin, poly lactic-co-glycolic acid, glucose-modified bovine serum albumin/procyanidin complexes, are briefly explored provide comprehensive overview current developments field. Our reveals that approaches offer unique advantages both delivery, potentially opening new avenues neurodegenerative conditions. synthesizes knowledge identifies directions future research strategies.
Language: Английский
Citations
0
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123454 - 123454
Published: Feb. 27, 2025
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125487 - 125487
Published: March 1, 2025
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 564 - 564
Published: April 13, 2025
Despite improvements in therapeutic approaches like immunotherapy and gene therapy, cancer still remains a serious threat to world health due its high incidence mortality rates. Limitations of conventional therapy include suboptimal targeting, multidrug resistance, systemic toxicity. A major challenge current oncology therapies is the development new delivery methods for antineoplastic drugs that act directly on target. One approach involves complexation antitumor with cyclodextrins (CDs) chitosan (CS) as an attempt counteract their primary limitations: low water solubility bioavailability, diminished vitro vivo stability, dose-dependent All those drawbacks may potentially exclude some candidates from clinical trials, thus integration into smart systems or drug-targeting technologies must be implemented. We intended overview drug based regard diagnosis management. This narrative review encompasses full-length articles published English between 2019 2025 (including online ahead print versions) PubMed-indexed journals, focusing recent research encapsulation diverse within nanosystems exhibit responsiveness various stimuli such pH, redox potential, folate receptor levels, thereby enhancing release bioactive compounds at tumor sites. The majority cited references focus most notable research, studies novel applications, scientific advancements field nanostructures functional materials employed oncological over last six years. Certainly, there are additional potential can facilitate drug’s upon activation, reactive oxygen species (ROS), enzymes, ATP level, hypoxia; however, our exclusively addresses aforementioned presented comprehensive manner.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144475 - 144475
Published: May 1, 2025
Language: Английский
Citations
0