Release of antibiotics from the materials for postosteomyelitic bone defect filling DOI Creative Commons
М. В. Стогов, А. Л. Шастов, Е. А. Киреева

et al.

Genij Ortopedii, Journal Year: 2024, Volume and Issue: 30(6), P. 873 - 880

Published: Dec. 18, 2024

Introduction The search for materials bone defect filling that would provide a release of antibiotics in therapeutic levels over long period is pressing issue the treatment patients with osteomyelitis. purpose work was to compare kinetics antibiotic from based on polyurethane polymers post-osteomyelitic defects. Materials and methods A comparative vitro analysis kinetic cefotaxime, vancomycin, meropenem two performed: one (RK series) other polymethyl methacrylate (PMMA series). In each series, were added original three proportions: polymer/ — 10:1 (group 1); 10:0.5 2), 10:0.25 3). samples incubated 10 ml saline at 37 °C. incubation solution changed daily during first week, then once week. Six group. Results It revealed volume eluted cefotaxime PMMA series higher than RK all concentrations. turn, vancomycin meropenem, it observed only group 1 samples. For groups 0.5 0.25, larger released noted series. found an effective (therapeutic) concentration more prolonged. there prolonged concentrations but smaller Discussion Each material showed its own elution profile them may have indications. RK-based has advantages terms duration doses. Conclusion studied longer PMMA-based material.

Language: Английский

Fundamentals and Advances in Stimuli-Responsive Hydrogels and Their Applications: A Review DOI Creative Commons
Iryna Protsak, Yevhenii M. Morozov

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 30 - 30

Published: Jan. 2, 2025

This review summarizes the fundamental concepts, recent advancements, and emerging trends in field of stimuli-responsive hydrogels. While numerous reviews exist on this topic, continues to evolve dynamically, certain research directions are often overlooked. To address this, we classify hydrogels based their response mechanisms provide an in-depth discussion key properties mechanisms, including swelling kinetics, mechanical properties, biocompatibility/biodegradability. We then explore hydrogel design, synthesis, structural engineering, followed by overview applications that relatively well established from a scientific perspective, biomedical uses (biosensing, drug delivery, wound healing, tissue engineering), environmental (heavy metal phosphate removal environment polluted water), soft robotics actuation. Additionally, highlight unconventional such as local micro-thermometers cell mechanotransduction. concludes with current challenges future prospects field, aiming inspire further innovations advancements bring them closer societal needs.

Language: Английский

Citations

6
A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials DOI Creative Commons
Hoon Choi, Wan-Sun Choi,

Jin-Oh Jeong

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

Citations

9
Sustained Delivery of Liraglutide Using Multivesicular Liposome Based on Mixed Phospholipids DOI Creative Commons

Runpeng Zhang,

Xinyu Yao, Siqi Gao

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 203 - 203

Published: Feb. 6, 2025

Background: Although peptides are widely used in the clinical treatment of various diseases due to their strong biological activity, they usually require frequent injections owing poor vivo half-life. Therefore, there is a need for sustained peptide formulations. Methods: In this study, liraglutide (Lir) and biocompatible multivesicular liposomes (MVLs) were utilized as model drug sustained-release carriers, respectively. The release rate Lir-MVLs was controlled by changing ratio SPC DEPC with different phase transition temperatures (PTT, PTTSPC = −20 °C, PTTDEPC 13 °C). Results: As increased, had more flexible lipid membranes, poorer structural stabilization, fewer internal vesicles larger particle sizes, contributing faster Lir. After subcutaneous injection Lir-MVLs, blood glucose concentration (BGC) db/db mice decreased levels. When SPC-DEPC greater than 85:15, too fast; BGC remained below 16 mM only 2–4 days, while when slow, case less 50:50, also 2–3 days. However, 75:25, could be maintained 8 indicating that properties best met pharmacological requirements Conclusions: This study investigated effects phospholipids PTT on characteristics provided ideas design preparations.

Language: Английский

Citations

0
Electrospinning in Drug Delivery: Progress and Future Outlook DOI Open Access

Naimah Abdul Halim,

N. Nallusamy, Rajamani Lakshminarayanan

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract There is intense research during the past few decades to design and fabricate drug delivery systems using electrospinning system. Electrospinning an efficient technique produce nanofiber materials with different dimensions morphologies by adjusting processing parameters. becoming innovative technology that promotes pursuit maintenance of human health. Herein, review discusses contribution in systems, summarising modification various system configurations effects process parameters on fibers, their application including carrier materials, loaded drugs release mechanisms illustrates medical applications. Finally, this challenges, bottlenecks, development prospects field terms scaling up for clinical use exploring potential solutions pave way establish future systems.

Language: Английский

Citations

0
Diversified nanocarrier design to optimize glucose oxidase-mediated anti-tumor therapy: Strategy and progress DOI

Yuhan Fu,

Jialin Sun, Chunyu Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141581 - 141581

Published: Feb. 1, 2025

Language: Английский

Citations

0
A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion Technology for Poorly Water-Soluble Drugs DOI Creative Commons

Zaid Dahma,

Covadonga Álvarez-Álvarez, Paloma Marina de la Torre-Iglesias

et al.

Colloids and Interfaces, Journal Year: 2025, Volume and Issue: 9(2), P. 17 - 17

Published: March 21, 2025

The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% new face market entry challenges due to low water solubility. Enhancing drug bioavailability thus essential developing pharmaceutical dosage forms. Many biopharmaceutical class II and IV are commonly prescribed treat inflammations, infections, pain from various pathologies. Their oral administration has several drawbacks, including significant first-pass liver effects, bioavailability, adverse gastrointestinal effects. Topical application gained relevance its advantages delivering directly the target site, avoiding irritation, increasing their effectiveness. However, topical hydrogel formulations with poorly water-soluble related skin’s permeability. Therefore, preparing hydrogels using solid dispersions (SDs) an effective strategy enhance dissolution rate soluble drugs, thereby improving bioavailability. In this review, concepts SDs, delivery systems, incorporating as well preparation methods, characterization, applications, will be discussed.

Language: Английский

Citations

0
Innovative Micro- and Nano-Architectures in Biomedical Engineering for Therapeutic and Diagnostic Applications DOI Creative Commons
Nargish Parvin, Sang Woo Joo,

Jae Hak Jung

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(4), P. 419 - 419

Published: March 31, 2025

The rapid evolution of micro- and nano-architectures is revolutionizing biomedical engineering, particularly in the fields therapeutic diagnostic micromechanics. This review explores recent innovations nanostructured materials their transformative impact on healthcare applications, ranging from drug delivery tissue engineering to biosensing diagnostics. Key advances fabrication techniques, such as lithography, 3D printing, self-assembly, have enabled unprecedented control over material properties functionalities at microscopic scales. These engineered architectures offer enhanced precision targeting controlled release delivery, foster cellular interactions improve sensitivity specificity devices. We examine critical design parameters, including biocompatibility, mechanical resilience, scalability, which influence clinical efficacy long-term stability. also highlights translational potential current limitations bringing these laboratory research practical applications. By providing a comprehensive overview trends, challenges, future perspectives, this article aims inform inspire further development that hold promise for advancing personalized medicine.

Language: Английский

Citations

0
Evaluation of Carboxymethyl Chitosan–Genipin Hydrogels as Reservoir Systems for Suramin Delivery in Epithelial Tissues DOI Creative Commons
David Encinas-Basurto, Victor H. Ruiz, Rick G. Schnellmann

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(5), P. 312 - 312

Published: April 23, 2025

Hydrogels (HDs) offer a promising platform for localized and sustained drug delivery. In this study, carboxymethyl chitosan (CMC)—based hydrogels were crosslinked with genipin evaluated the controlled release tissue retention of suramin, polyanionic anti-inflammatory antifibrotic properties. The influence crosslinking density (1%, 3%, 5%) on release, permeation kinetics, was investigated using in vitro synthetic membranes reconstructed human epithelial models. 1% HD exhibited highest cumulative (48.8 ± 6.8 μg/cm2 membranes; 24.06 7.33 models), along profile governed by first-order Fickian diffusion kinetics. Notably, formulation also demonstrated enhanced transmembrane flux (>140 μg/cm2/h after six hours), suggesting that lower favors both diffusional mobility depot functionality. contrast, free suramin solution displayed limited interaction minimal permeation, highlighting role hydrogel matrix regulating local bioavailability. These findings demonstrate CMC–genipin can closely modulate delivery kinetics through density, offering biocompatible strategy treatment ulcerated conditions such as oral mucositis or chronic wounds. Diffusion models included multilayer membrane (Strat-M®) epidermis (EpiDerm™) to simulate skin-like barrier

Language: Английский

Citations

0
Injectable and In Situ Phospholipid-Based Phase Separation Gel for Sustained Delivery of Altrenogest DOI Creative Commons
Dongbo Li, Awn Abbas, Nanxin Li

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 847 - 847

Published: Dec. 23, 2024

Altrenogest is a key regulatory hormone for intensive and batch management of reserve sows in breeding farms. As synthetic hormone, altrenogest could make ovaries stay at the initial stage follicles inhibit estrus ovulation animals. However, currently used oral solution needs to be administered continuously every day more than two weeks clinical practice. In this study we developed phospholipid-based injectable gel carrying decrease number administrations, sustain release drug, enhance therapeutic efficacy use. The had viscosity 100 cP before phase transition over 1,000,000 after transition. vitro, can released from weeks. pharmacokinetic results showed that AUC (0–∞) was almost double solution. MRT 40.92 ± 7.21 h t1/2 80.03 20.79 h. demonstrated excellent fluidity, ease injectability, high drug-loading capacity, appropriate sustained-release characteristics both vitro vivo, making it potential drug delivery system swine production.

Language: Английский

Citations

1
Hybrid Hydrogel Supplemented with Algal Polysaccharide for Potential Use in Biomedical Applications DOI Creative Commons
Dana Stan, Andreea-Cristina Mirica, Sorin Mocanu

et al.

Gels, Journal Year: 2024, Volume and Issue: 11(1), P. 17 - 17

Published: Dec. 30, 2024

Hydrogels are a viable option for biomedical applications due to their biocompatibility, biodegradability, and ability incorporate various healing agents while maintaining biological efficacy. This study focused on the preparation characterization of novel hybrid hydrogels enriched with natural algae compound Ulvan potential use in wound dressings. The hydrogel membranes involved multiple methods assess structural, mechanical, chemical properties, such as pH measurements, swelling, moisture content uptake, gel fraction, hydrolytic degradation, protein adsorption denaturation tests, rheological SEM, biocompatibility testing, scratch assay. obtained higher concentration (1 mg/mL) exhibited superior mechanical swelling index 264%, water 55%, lower degradation percentage. In terms inclusion ULV composition enhanced strength, Alginate + PVA 1.0ULV sample demonstrated greatest resistance deformation. All good cell viability above 70% no obvious morphological modifications. addition potentiates regenerative effect membranes. Subsequent studies will focus encapsulating bioactive compounds, investigating release behavior, evaluating active effects.

Language: Английский

Citations

1