Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 27, 2024
Severe
spinal
cord
injuries
(SCI)
lead
to
loss
of
functional
activity
the
body
below
injury
site,
affect
a
person’s
ability
self-care
and
have
direct
impact
on
performance.
Due
structural
features
role
in
body,
consequences
SCI
cannot
be
completely
overcome
at
expense
endogenous
regenerative
potential
and,
developing
over
time,
severe
complications
years
after
injury.
Thus,
primary
task
this
type
treatment
is
create
artificial
conditions
for
growth
damaged
nerve
fibers
through
area
SCI.
Solving
problem
possible
using
tissue
neuroengineering
involving
technology
replacing
natural
environment
with
synthetic
matrices
(for
example,
hydrogels)
combination
stem
cells,
particular,
neural/progenitor
cells
(NSPCs).
This
approach
can
provide
maximum
stimulation
support
axons
neurons
their
myelination.
In
review,
we
consider
currently
available
options
improving
condition
(use
NSC
transplantation
or/and
replacement
matrix,
specifically
hydrogel).
We
emphasise
expediency
effectiveness
hydrogel
matrix
+
NSCs
complex
system
used
reconstruction
Since
such
(a
engineering
cell
therapy),
our
opinion,
allows
not
only
creation
supporting
regeneration
or
mechanical
cord,
but
also
strengthen
regeneration,
prevent
spread
inflammatory
process,
promote
restoration
lost
reflex,
motor
sensory
functions
injured
cord.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(27)
Published: Aug. 24, 2023
Hydrogels,
a
class
of
materials
with
3D
network
structure,
are
widely
used
in
various
applications
therapeutic
delivery,
particularly
cancer
therapy.
Micro
and
nanogels
as
miniaturized
structures
the
bioengineered
hydrogels
may
provide
extensive
benefits
over
common
encapsulation
controlled
release
small
molecular
drugs,
macromolecular
therapeutics,
even
cells.
Cancer
immunotherapy
is
rapidly
developing,
micro/nanostructured
have
gained
wide
attention
regarding
their
engineered
payload
properties
that
enhance
systemic
anticancer
immunity.
Additionally,
they
great
candidate
due
to
local
administration
focus
on
immune
cell
manipulation
favor
active
passive
immunotherapies.
Although
applied
locally,
such
can
also
activate
antitumor
responses
by
releasing
nanovaccines
safely
effectively
inhibiting
tumor
metastasis
recurrence.
However,
mostly
locally
administered
carriers
stimulate
cells
lysate,
or
nanovaccines.
In
this
review,
latest
developments
summarized
using
particular
emphasis
function
depending
route.
Moreover,
potential
for
clinical
translation
these
hydrogel-based
immunotherapies
discussed.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5152 - 5152
Published: May 9, 2024
Cancer
immunotherapy
relies
on
the
insight
that
immune
system
can
be
used
to
defend
against
malignant
cells.
The
aim
of
cancer
is
utilize,
modulate,
activate,
and
train
amplify
antitumor
T-cell
immunity.
In
parallel,
response
damaged
tissue
also
crucial
in
determining
success
or
failure
an
implant.
Due
their
extracellular
matrix
mimetics
tunable
chemical
physical
performance,
hydrogels
are
promising
platforms
for
building
immunomodulatory
microenvironments
realizing
therapy
regeneration.
However,
submicron
nanosized
pore
structures
within
not
favorable
modulating
cell
function,
such
as
invasion,
migration,
immunophenotype.
contrast,
with
a
porous
structure
only
allow
nutrient
transportation
metabolite
discharge
but
offer
more
space
function.
this
review,
design
strategies
influencing
factors
regeneration
first
discussed.
Second,
effects
therapeutic
outcomes
different
highlighted.
Beyond
that,
review
highlights
size
function
potential
signal
transduction.
Finally,
remaining
challenges
perspectives
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 27, 2024
Severe
spinal
cord
injuries
(SCI)
lead
to
loss
of
functional
activity
the
body
below
injury
site,
affect
a
person’s
ability
self-care
and
have
direct
impact
on
performance.
Due
structural
features
role
in
body,
consequences
SCI
cannot
be
completely
overcome
at
expense
endogenous
regenerative
potential
and,
developing
over
time,
severe
complications
years
after
injury.
Thus,
primary
task
this
type
treatment
is
create
artificial
conditions
for
growth
damaged
nerve
fibers
through
area
SCI.
Solving
problem
possible
using
tissue
neuroengineering
involving
technology
replacing
natural
environment
with
synthetic
matrices
(for
example,
hydrogels)
combination
stem
cells,
particular,
neural/progenitor
cells
(NSPCs).
This
approach
can
provide
maximum
stimulation
support
axons
neurons
their
myelination.
In
review,
we
consider
currently
available
options
improving
condition
(use
NSC
transplantation
or/and
replacement
matrix,
specifically
hydrogel).
We
emphasise
expediency
effectiveness
hydrogel
matrix
+
NSCs
complex
system
used
reconstruction
Since
such
(a
engineering
cell
therapy),
our
opinion,
allows
not
only
creation
supporting
regeneration
or
mechanical
cord,
but
also
strengthen
regeneration,
prevent
spread
inflammatory
process,
promote
restoration
lost
reflex,
motor
sensory
functions
injured
cord.
